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Sickle cell Anaemia: The Need for Increased Drug Development in Africa

Sickle cell Anaemia: The Need for Increased Drug Development in Africa AbstractSickle cell anaemia is a life-threatening genetic disease that causes damage to red blood cells by polymerisation of deoxygenated haemoglobin. It is highly prevalent in Africa especially in regions with high prevalence of malaria. Over the years, hydroxyurea had been the only promising drug used in the management of sickle cell anaemia; however, it has been found to be unaffordable and not readily available to the affected poor people in rural areas. Several challenges face drug development efforts in Africa yet there remains a significant need for the development and standardisation of newer, cheaper, and effective anti-sickling drugs that would be readily affordable and available to meet the needs of the African populace. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Public Health Issues de Gruyter

Sickle cell Anaemia: The Need for Increased Drug Development in Africa

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Publisher
de Gruyter
Copyright
© 2022 Damilola Esther Olukorede et al., published by Sciendo
eISSN
2720-1961
DOI
10.2478/aphi-2022-0002
Publisher site
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Abstract

AbstractSickle cell anaemia is a life-threatening genetic disease that causes damage to red blood cells by polymerisation of deoxygenated haemoglobin. It is highly prevalent in Africa especially in regions with high prevalence of malaria. Over the years, hydroxyurea had been the only promising drug used in the management of sickle cell anaemia; however, it has been found to be unaffordable and not readily available to the affected poor people in rural areas. Several challenges face drug development efforts in Africa yet there remains a significant need for the development and standardisation of newer, cheaper, and effective anti-sickling drugs that would be readily affordable and available to meet the needs of the African populace.

Journal

Annals of Public Health Issues – de Gruyter

Published: Jan 1, 2022

Keywords: Sickle; cell; disease; anaemia; drug; development; Africa

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