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Synthesis of thiophene and N-substituted thieno[3,2-d] pyrimidine derivatives as potent antitumor and antibacterial agents

Synthesis of thiophene and N-substituted thieno[3,2-d] pyrimidine derivatives as potent antitumor... REFERENCES1. H. N. Hafez and A. B. A. El-Gazzar, Design and synthesis of 3-pyrazolyl-thiophene, thieno[2,3-d] pyrimidines as new bioactive and pharmacological activities, Bioorg. Med. Chem. Lett. 18 (2008) 5222–5227; DOI: 10.1016/j.bmcl.2008.08.071.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000259326800015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f310.1016/j.bmcl.2008.08.0712. S. Abbas, M. Hussain, S. Ali, M. Parvez, A. Raza, A. Haider and J. Iqbal, Structural, enzyme inhibition, antibacterial and DNA protection studies of organotin(IV) derivatives of thiophene-2-carboxylic acid, J. Organomet. 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Synthesis of thiophene and N-substituted thieno[3,2-d] pyrimidine derivatives as potent antitumor and antibacterial agents

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de Gruyter
Copyright
© 2017 Hend N. Hafez et al., published by De Gruyter Open
ISSN
1846-9558
eISSN
1846-9558
DOI
10.1515/acph-2017-0028
pmid
28858838
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Abstract

REFERENCES1. H. N. Hafez and A. B. A. El-Gazzar, Design and synthesis of 3-pyrazolyl-thiophene, thieno[2,3-d] pyrimidines as new bioactive and pharmacological activities, Bioorg. Med. Chem. Lett. 18 (2008) 5222–5227; DOI: 10.1016/j.bmcl.2008.08.071.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000259326800015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f310.1016/j.bmcl.2008.08.0712. S. Abbas, M. Hussain, S. Ali, M. Parvez, A. Raza, A. Haider and J. Iqbal, Structural, enzyme inhibition, antibacterial and DNA protection studies of organotin(IV) derivatives of thiophene-2-carboxylic acid, J. Organomet. Chem. 724 (2013) 255–261; DOI: 10.1016/j.jorganchem.2012.11.033.10.1016/j.jorganchem.2012.11.033http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000314113400035&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f33. Y. Ni. A. Gopalsamy, D. Cole, Y. Hu, R. Denny, M. Lpek, J. Liu, J. Lee, J. P. Hall, M. Luong, J. B. Telliez and L. L. Lin, Identification and SAR of a new series of thieno[3,2-d]pyrimidines as Tpl2 kinase inhibitors, Bioorg. Med. Chem. Lett. 21 (2011) 5952–5956; DOI: 10.1016/j.bmcl.2011.07.069.10.1016/j.bmcl.2011.07.0694. T. P. Heffron, M. Berry, G. Castanedo, C. Chang, I. Chuckowree, J. Dotson, A. Folkes, J. Gunzner, J. D. Lesnick, C. Lewis, S. Mathieu, J. Nonomiya, A. Olivero, J. Pang, D. Peterson, L. Salphati, D. Sampath, S. Sideris, D. P. Sutherlin, V. Tsui, N. C. Wan, S. Wang, S. Wong and B. Y. Zhu, Identification of GNE-477, a potent and efficacious dual PI3K/mTOR inhibitor, Bioorg. Med. Chem. Lett. 20 (2010) 2408–2411; DOI: 10.1016/j.bmcl.2010.03.046.10.1016/j.bmcl.2010.03.0465. Q. Tan, Z. Zhang, J. Hui, Y. Zhao and L. Zhu, Synthesis and anticancer activities of thieno [3,2-d] pyrimidines as novel HDAC inhibitors, Bioorg. Med. Chem. 22 (2014) 358–365; DOI: 10.1016/j.bmc.2013.11.021.10.1016/j.bmc.2013.11.021http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000329068400032&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f36. J. Kim, J. Kwon, D. Lee, S. Jo, O. Dongsik, C. Jihyun, E. Park, J. Y. Hwang, Y. Ko, I. Choi, M. K. Ju, J. Ahn, J. Kim, S.-J. Han, T.-H. Kim, J. Cechetto, J. Nam, S. Ahn, P. Sommer, M. Liuzzi and J. Lee, Serendipitous discovery of 2-((phenylsulfonyl)methyl)-thieno[3,2-d]pyrimidine derivatives as novel HIV-1 replication inhibitors, Bioorg. Med. Chem Lett. 24 (2014) 5473–5477; DOI: 10.1016/j.bmcl.2014.10.007.10.1016/j.bmcl.2014.10.007http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000345125500027&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f37. K. W. Temburnikar, S. C. Zimmermann, N. T. Kim, C. R. Ross, C. Gelbmann, C. E. Salomon, G. M. Wilson, J. Balzarini and K. L. Seley-Radtke, Antiproliferative activities of halogenated thieno[3,2-d] pyrimidines, Bioorg. Med. Chem. 22 (2014) 2113–2122; DOI: 10.1016/j.bmc.2014.02.033.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000334337800011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f310.1016/j.bmc.2014.02.0338. A. J. Folkes, K. Ahmadi, W. K. Alderton, S. Alix, S. J. Baker, G. Box, I. S. Chuckowree, P. A. Clarke, P. Depledge, S. A. Eccles, L. S. Friedman, A. Hayes, T. C. 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Journal

Acta Pharmaceuticade Gruyter

Published: Sep 1, 2017

References