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- Publisher
- de Gruyter
- Copyright
- © 2023 Kertys M. et al., published by Sciendo
- ISSN
- 1335-8421
- eISSN
- 1338-4139
- DOI
- 10.2478/acm-2023-0004
- Publisher site
- See Article on Publisher Site
Abstract
AbstractDirect oral anticoagulants represent a significant group of drugs used in the prevention or treatment of venous thromboembolic events and stroke in patients with atrial fibrillation. Although routine therapy monitoring is not required, there is an increasing evidence that plasma levels may vary between individuals, suggesting the benefit of plasma levels measurement in some situations. Therapeutic drug monitoring is becoming more popular and accessible to the broader population. Introducing microsampling techniques for the quantitative collection of blood samples has arisen nowadays. The volumetric absorptive microsampling approach using a commercially available device such as a Mitra stick overcomes the hematocrit effect present in the dry blood spot technique. This review discusses the possible application of the volumetric absorptive microsampling approach in monitoring direct oral anticoagulant therapy efficacy.
Journal
Acta Medica Martiniana – de Gruyter
Published: Apr 1, 2023
Keywords: direct oral anticoagulants; microsampling techniques; therapeutic drug monitoring; volumetric absorptive microsampling