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/lp/karger/expression-of-epidermal-growth-factor-receptor-and-transforming-growth-itfhLSvViy
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- Publisher
- Karger
- Copyright
- © 2015 S. Karger AG, Basel
- ISSN
- 1661-7649
- eISSN
- 1661-7657
- DOI
- 10.1159/000447140
- Publisher site
- See Article on Publisher Site
Abstract
Introduction: Overexpression of epidermal growth factor receptor (EGFR) has been described in several solid tumors including bladder cancer. Transforming growth factor alpha (TGFα) is frequently deregulated in neoplastic cells and plays a role in the development of bladder cancer. TGFα-EGFR ligand-receptor combination constitutes an important event in multistep tumorigenesis. Methods: This study was done on 30 bladder biopsies from patients with urothelial carcinoma, 15 with squamous cell carcinoma, 10 with cystitis and 5 normal control bladder specimens. All were immuohistochemically stained with EGFR and TGFα antibodies. Results: EGFR and TGFα were over-expressed in higher grades and late stages of bladder cancer. Moreover, they show higher expression in squamous cell carcinoma compared to urothelial carcinoma and in schistosomal associated lesions than in non-schistosomal associated lesions. Conclusion: EGFR and TGFα could be used as prognostic predictors in early stage and grade of bladder cancer cases, especially those with schistosomal association. In addition they can help in selecting patients who can get benefit from anti-EGFR molecular targeted therapy.
Journal
Current Urology – Karger
Published: Jan 1, 2016
Keywords: Bladder cancer; Epidermal growth factor receptor; Immunohistochemistry; Schistosomiasis; Transforming growth factor-α