Access the full text.
Sign up today, get DeepDyve free for 14 days.
S. Khin, R. Kitazawa, N. Win, T. Aye, Kiyoshi Mori, T. Kondo, S. Kitazawa (2009)BAMBI gene is epigenetically silenced in subset of high‐grade bladder cancer
International Journal of Cancer, 125
Vali Izadifar, Vali Izadifar, Vali Izadifar, W. Boer, W. Boer, W. Boer, Béatrice Muscatelli-Groux, Béatrice Muscatelli-Groux, Béatrice Muscatelli-Groux, Pascale Maillé, Pascale Maillé, Pascale Maillé, Theodorus Kwast, Theodorus Kwast, Theodorus Kwast, Dominique Chopin, Dominique Chopin, Dominique Chopin (1999)Expression of transforming growth factor beta1 and its receptors in normal human urothelium and human transitional cell carcinomas.
Human pathology, 30 4
Yigong Shi, J. Massagué (2003)Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
Cell, 113 6
N.Gad Mawla, M. Bolkainy, H. Khaled (2001)Bladder cancer in Africa: update.
Seminars in oncology, 28 2
F. Chen, R. Weinberg (1995)Biochemical evidence for the autophosphorylation and transphosphorylation of transforming growth factor beta receptor kinases.
Proceedings of the National Academy of Sciences of the United States of America, 92
D. Sidransky, E. Messing (1992)Molecular genetics and biochemical mechanisms in bladder cancer. Oncogenes, tumor suppressor genes, and growth factors.
The Urologic clinics of North America, 19 4
B. Pasche (2001)Role of transforming growth factor beta in cancer
Journal of Cellular Physiology, 186
A. Roberts, M. Sporn, R. Assoian, J. Smith, N. Roche, L. Wakefield, U. Heine, L. Liotta, V. Falanga, J. Kehrl (1986)Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.
Proceedings of the National Academy of Sciences of the United States of America, 83 12
W. Boer, A. Houtsmuller, V. Izadifar, B. Muscatelli-Groux, T. Kwast (1997)Expression and functions of EGF FGF and TGFβ‐growth‐factor family members and their receptors in invasive human transitional‐cell‐carcinoma cells
International Journal of Cancer, 71
K. Park, Seong-Jin Kim, Y. Bang, Jae‐Gahb Park, N. Kim, A. Roberts, M. Sporn (1994)Genetic changes in the transforming growth factor beta (TGF-beta) type II receptor gene in human gastric cancer cells: correlation with sensitivity to growth inhibition by TGF-beta.
Proceedings of the National Academy of Sciences of the United States of America, 91 19
David Rollinson (2009)A wake up call for urinary schistosomiasis: reconciling research effort with public health importance
Ja‐Hong Kim, S. Shariat, I. Kim, Andres Menesses-Diaz, H. Tokunaga, T. Wheeler, S. Lerner (2001)Predictive value of expression of transforming growth factor‐β1 and its receptors in transitional cell carcinoma of the urinary bladder
McGarvey, Tait, Tomaszewski, Malkowicz (1999)Expression of Transforming Growth Factor-beta Receptors and Related Cell-Cycle Components in Transitional-Cell Carcinoma of the Bladder.
Molecular urology, 3 4
Mitchell Steiner (1995)Review of peptide growth factors in benign prostatic hyperplasia and urological malignancy.
The Journal of urology, 153 4
C. Wilkins-Port, P. Higgins (2007)Regulation of Extracellular Matrix Remodeling following Transforming Growth Factor-β1/Epidermal Growth Factor-Stimulated Epithelial-Mesenchymal Transition in Human Premalignant Keratinocytes
Cells Tissues Organs, 185
H. Pearse, R. Reed, C. Hodges (1978)Radical cystectomy for bladder cancer.
The Journal of urology, 119 2
M. El-Bolkainy, N. Mokhtar, MCh Ghoneim, M. Hussein (1981)The impact of schistosomiasis on the pathology of bladder carcinoma
S. Markowitz, Jing Wang, L. Myeroff, R. Parsons, L. Sun, J. Lutterbaugh, R. Fan, E. Zborowska, K. Kinzler, B. Vogelstein, B. Vogelstein, M. Brattain, J. Willson (1995)Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability.
Science, 268 5215
J. Munger, J. Harpel, P. Gleizes, R. Mazzieri, I. Nunes, D. Rifkin (1997)Latent transforming growth factor-beta: structural features and mechanisms of activation.
Kidney international, 51 5
I. Eder, Arnulf Stenzl, A. Hobisch, M. Cronauer, G. Bartsch, H. Klocker (1996)Transforming growth factors-beta 1 and beta 2 in serum and urine from patients with bladder carcinoma.
The Journal of urology, 156 3
A. Sandberg, C. Berger (1994)Review of chromosome studies in urological tumors. II. Cytogenetics and molecular genetics of bladder cancer.
The Journal of urology, 151 3
Masato Okamoto, Ryoichi Oyasu (1997)Overexpression of transforming growth factor beta type I receptor abolishes malignant phenotype of a rat bladder carcinoma cell line.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 8 8
H. Miyamoto, Y. Kubota, T. Shuin, S. Torigoe, Y. Dobashi, M. Hosaka (1995)Expression of transforming growth factor‐beta 1 in human bladder cancer
S. Hsu, L. Raine (1981)Protein A, avidin, and biotin in immunohistochemistry.
A. Marx, A. Hafner-Marx (2004)World Health Organization Classification of Tumors. Pathology and Genetics of Tumors of the Urinary System and Male Genital Organs
Jing Wang, Luzhe Sun, L. Myeroff, Xiaofan Wang, L. Gentry, Junhua Yang, Jiurong Liang, E. Zborowska, S. Markowitz, J. Willson, M. Brattain (1995)Demonstration That Mutation of the Type II Transforming Growth Factor β Receptor Inactivates Its Tumor Suppressor Activity in Replication Error-positive Colon Carcinoma Cells (*)
The Journal of Biological Chemistry, 270
Yigong Shi, J. Massagué (2003)Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus
A. Castillejo, N. Rothman, C. Murta-Nascimento, N. Malats, M. García-Closas, Angeles Gómez-Martínez, J. Lloreta, A. Tardón, C. Serra, R. Garcı́a-Closas, S. Chanock, D. Silverman, M. Dosemeci, M. Kogevinas, A. Carrato, J. Soto, F. Real (2009)TGFB1 and TGFBR1 polymorphic variants in relationship to bladder cancer risk and prognosis
International Journal of Cancer, 124
Ch. Wittekind, M. Gospodarowicz, L. Sobin (2009)TNM Classification of Malignant Tumours, 7th Edition
P. Franzén, P. Dijke, H. Ichijo, H. Yamashita, P. Schulz, C. Heldin, K. Miyazono (1993)Cloning of a TGFβ type I receptor that forms a heteromeric complex with the TGFβ type II receptor
E. Yang, Harold Moses (1990)Transforming growth factor beta 1-induced changes in cell migration, proliferation, and angiogenesis in the chicken chorioallantoic membrane
The Journal of Cell Biology, 111
Objective: To study the expression of transforming growth factor beta 1 (TGFB1) protein and TGFB R1 (receptor) in bladder tissue sections of patients with bladder cancer (urothelial carcinoma and squamous cell carcinoma) associated with schistosomiasis or not and to correlate both markers with tumor grade, pathological stage and schistosome infestation. Patients and Methods: Sixteen patients with chronic cystitis and 60 with malignant bladder lesions (33 bladder cancer cases associated with schistosomiasis and 27 not associated) were included in the study. Five healthy individuals served as controls. TGFB1 protein and TGFB R1 expression in bladder tissue were measured using immunohistochemical techniques. Results: TGFB1 showed significant over-expression in the malignant group compared to the chronic cystitis group (p < 0.01). TGFB1 was significantly increased in the schistosomal associated bladder cancer (SABC) (including urothelial carcinoma associated with schistosomiasis and squamous cell carcinoma cases) group compared to the non-schistosomal associated bladder cancer group (NSABC) (including urothelial carcinoma not associated with schistosomiasis) (p < 0.05). Expression of TGFB1 was increased with an increase of tumor grade and stage. TGFB R1 showed decreased expression in urothelial carcinoma compared to the squamous cell carcinoma cases (p < 0.05). TGFB R1 showed decreased expression in the SABC group compared to the NSABC group (p < 0.05). TGFB R1 showed decreased expression in relation to the histopathological grade and stage. Conclusion: There is increased expression of TGFB1 protein in SABC compared to NSABC, while there is loss of expression of TGFB R1 in SABC compared to NSABC. TGFB1 and TGFB R1 expression could be used as biological markers for prediction of the clinical outcome of bladder carcinoma. This may help in selecting patients for more intensive surgical or chemotherapeutic approaches.
Current Urology – Karger
Published: Jan 1, 2011
Keywords: Transforming growth factor beta 1 protein; Transforming growth factor beta 1 receptor; Urothelial carcinoma; Squamous cell carcinoma; Schistosomiasis
Access the full text.
Sign up today, get DeepDyve free for 14 days.