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Poorly differentiated carcinomas of the bladder may develop endocrine activity by producing granulocyte colony-stimulating factor and parathyroid hormone-related protein. This may lead to a substantially elevated white blood cell count and hypercalcemia with subsequent distinctive clinical features. We report a well-documented case of high grade aggressive bladder cancer with paraneoplastic elevation of granulocyte colony-stimulating factor and parathyroid hormone-related protein. Serum levels of calcium and white blood cell count were highly increased, whereas parathyroid hormone level was slightly decreased. The altered blood levels correlated well with a decrease of vigilance.
Current Urology – Karger
Published: Jan 1, 2009
Keywords: Bladder cancer; Granulocyte colony-stimulating factor; Parathyroid-hormone-related protein
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