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Prediction of Creatinine Clearance from Serum Creatinine

Prediction of Creatinine Clearance from Serum Creatinine A formula has been developed to predict creatinine clearance (C<sub>cr</sub>) from serum creatinine (S<sub>cr</sub>) in adult males: Ccr = (140 – age) (wt kg)/72 × S<sub>cr</sub>(mg/100ml) (15% less in females). Derivation included the relationship found between age and 24-hour creatinine excretion/kg in 249 patients aged 18–92. Values for C<sub>cr</sub> were predicted by this formula and four other methods and the results compared with the means of two 24-hour C<sub>cr’s</sub> measured in 236 patients. The above formula gave a correlation coefficient between predicted and mean measured Ccr·s of 0.83; on average, the difference between predicted and mean measured values was no greater than that between paired clearances. Factors for age and body weight must be included for reasonable prediction. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Nephron Journals Karger

Prediction of Creatinine Clearance from Serum Creatinine

The Nephron Journals , Volume 16 (1): 11 – Jan 1, 1976

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Publisher
Karger
Copyright
© 1976 S. Karger AG, Basel
ISSN
1660-8151
eISSN
2235-3186
DOI
10.1159/000180580
Publisher site
See Article on Publisher Site

Abstract

A formula has been developed to predict creatinine clearance (C<sub>cr</sub>) from serum creatinine (S<sub>cr</sub>) in adult males: Ccr = (140 – age) (wt kg)/72 × S<sub>cr</sub>(mg/100ml) (15% less in females). Derivation included the relationship found between age and 24-hour creatinine excretion/kg in 249 patients aged 18–92. Values for C<sub>cr</sub> were predicted by this formula and four other methods and the results compared with the means of two 24-hour C<sub>cr’s</sub> measured in 236 patients. The above formula gave a correlation coefficient between predicted and mean measured Ccr·s of 0.83; on average, the difference between predicted and mean measured values was no greater than that between paired clearances. Factors for age and body weight must be included for reasonable prediction.

Journal

The Nephron JournalsKarger

Published: Jan 1, 1976

Keywords: Serum creatinine; Creatinine clearance; Creatinine excretion; Renal function; Age

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