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Tobacco Smoking Impairs the Local Immunosurveillance in the Uterine Cervix

Tobacco Smoking Impairs the Local Immunosurveillance in the Uterine Cervix Previous reports have supported an association between tobacco smoking and cervical neoplasia. Our observations show an association between smoking and a reduction of the numerical densities of Langerhans cells and of helper/ inducer T lymphocytes in the squamous epithelia of the transformation zone of the uterine cervix. This suggests a local impairment of cell-mediated immunity by smoking. This immunosuppressive effect could support the concept that smoking is an independent risk factor for cervical neoplasia. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Gynecologic and Obstetric Investigation Karger

Tobacco Smoking Impairs the Local Immunosurveillance in the Uterine Cervix

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Publisher
Karger
Copyright
© 1995 S. Karger AG, Basel
ISSN
0378-7346
eISSN
1423-002X
DOI
10.1159/000292372
Publisher site
See Article on Publisher Site

Abstract

Previous reports have supported an association between tobacco smoking and cervical neoplasia. Our observations show an association between smoking and a reduction of the numerical densities of Langerhans cells and of helper/ inducer T lymphocytes in the squamous epithelia of the transformation zone of the uterine cervix. This suggests a local impairment of cell-mediated immunity by smoking. This immunosuppressive effect could support the concept that smoking is an independent risk factor for cervical neoplasia.

Journal

Gynecologic and Obstetric InvestigationKarger

Published: Jan 1, 2010

Keywords: Immunostaining; Cervix; Smoking; Langerhans cells; Lymphocytes

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