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A systematic review of antibiotic utilization in China

A systematic review of antibiotic utilization in China ObjectivesReliable data about antibiotic utilization in the large pharmaceutical market of the world's most populous country, the People's Republic of China, are in short supply. Although many primary studies have investigated the use of antibiotics in China, most of the relevant studies were published in the Chinese language. This systematic review aims to summarize reported percentages of outpatient encounters resulting in the prescription of antibiotics in China.MethodsWe systematically searched and reviewed studies of antibiotic prescribing patterns in China, published in Chinese or English between 2000 and August 2012. The study quality was assessed and the overall percentage of outpatient encounters resulting in the prescription of antibiotics was calculated using random-effects meta-analysis. Subgroup analyses were conducted to investigate heterogeneity across studies.ResultsWe included 57 eligible studies (with a total of 556 435 outpatient encounters). The overall percentage of outpatients prescribed antibiotics was 50.3% (95% CI: 47.4%–53.1%). Of the outpatients prescribed antibiotics, 74.0% (95% CI: 71.3%–76.6%) were prescribed one antibiotic, 23.3% (95% CI: 21.1%–25.7%) were prescribed two antibiotics and 2.0% (95% CI: 1.3%–2.8%) were prescribed three or more antibiotics. The proportion of antibiotic utilization differed greatly across hospital levels and geographical regions and fluctuated over time.ConclusionsThe percentage use of antibiotics is high in China. The excessive use of antibiotics is particularly more problematic in lower-level hospitals and in less developed western China. The implementation and impact of the national efforts to control the excessive use of antibiotics should be appropriately evaluated. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Antimicrobial Chemotherapy Oxford University Press

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References (34)

Publisher
Oxford University Press
Copyright
© The Author 2013. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com
Subject
Systematic review
ISSN
0305-7453
eISSN
1460-2091
DOI
10.1093/jac/dkt223
pmid
23800903
Publisher site
See Article on Publisher Site

Abstract

ObjectivesReliable data about antibiotic utilization in the large pharmaceutical market of the world's most populous country, the People's Republic of China, are in short supply. Although many primary studies have investigated the use of antibiotics in China, most of the relevant studies were published in the Chinese language. This systematic review aims to summarize reported percentages of outpatient encounters resulting in the prescription of antibiotics in China.MethodsWe systematically searched and reviewed studies of antibiotic prescribing patterns in China, published in Chinese or English between 2000 and August 2012. The study quality was assessed and the overall percentage of outpatient encounters resulting in the prescription of antibiotics was calculated using random-effects meta-analysis. Subgroup analyses were conducted to investigate heterogeneity across studies.ResultsWe included 57 eligible studies (with a total of 556 435 outpatient encounters). The overall percentage of outpatients prescribed antibiotics was 50.3% (95% CI: 47.4%–53.1%). Of the outpatients prescribed antibiotics, 74.0% (95% CI: 71.3%–76.6%) were prescribed one antibiotic, 23.3% (95% CI: 21.1%–25.7%) were prescribed two antibiotics and 2.0% (95% CI: 1.3%–2.8%) were prescribed three or more antibiotics. The proportion of antibiotic utilization differed greatly across hospital levels and geographical regions and fluctuated over time.ConclusionsThe percentage use of antibiotics is high in China. The excessive use of antibiotics is particularly more problematic in lower-level hospitals and in less developed western China. The implementation and impact of the national efforts to control the excessive use of antibiotics should be appropriately evaluated.

Journal

Journal of Antimicrobial ChemotherapyOxford University Press

Published: Nov 25, 2013

Keywords: antibiotic prescription usage pharmacoepidemiology

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