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Effectiveness of Varicella Vaccine in Children Infected with HIV

Effectiveness of Varicella Vaccine in Children Infected with HIV Although varicella vaccine is given to clinically stable human immunodeficiency virus (HIV)-infected children, its effectiveness is unknown. We assessed its effectiveness by reviewing the medical records of closely monitored HIV-infected children, including those receiving highly active antiretroviral therapy (HAART) between 1989 and 2007. Varicella immunization and development of varicella or herpes zoster were noted. Effectiveness was calculated by subtracting from 1 the rate ratios for the incidence rates of varicella or herpes zoster in vaccinated versus unvaccinated children. The effectiveness of the vaccine was 82% (95% confidence interval [CI], 24%-99%; P p .01) against varicella and was 100% (95% CI, 67%-100%; P ! .001) against herpes zoster. When the analysis was controlled for receipt of HAART, vaccination remained highly protective against herpes zoster. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Infectious Diseases Oxford University Press

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References (15)

Publisher
Oxford University Press
Copyright
© Published by Oxford University Press.
Subject
Major Articles And Brief Reports
ISSN
0022-1899
eISSN
1537-6613
DOI
10.1086/652798
pmid
20441519
Publisher site
See Article on Publisher Site

Abstract

Although varicella vaccine is given to clinically stable human immunodeficiency virus (HIV)-infected children, its effectiveness is unknown. We assessed its effectiveness by reviewing the medical records of closely monitored HIV-infected children, including those receiving highly active antiretroviral therapy (HAART) between 1989 and 2007. Varicella immunization and development of varicella or herpes zoster were noted. Effectiveness was calculated by subtracting from 1 the rate ratios for the incidence rates of varicella or herpes zoster in vaccinated versus unvaccinated children. The effectiveness of the vaccine was 82% (95% confidence interval [CI], 24%-99%; P p .01) against varicella and was 100% (95% CI, 67%-100%; P ! .001) against herpes zoster. When the analysis was controlled for receipt of HAART, vaccination remained highly protective against herpes zoster.

Journal

Journal of Infectious DiseasesOxford University Press

Published: Jun 15, 2010

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