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Extrapyramidal signs in cognitively intact elderly people

Extrapyramidal signs in cognitively intact elderly people Abstract Aim: to investigate the prevalence of extrapyramidal signs in elderly people and their relationship to disease. Setting and subjects: 151 non-demented subjects age 65 and over living within a defined geographical area in Nottingham who were participating in the MRC multicentre Cognitive Function and Ageing Study. Measurements: subjects were assessed at home. Extrapyramidal signs were rated according to a standardized neurological examination using items from the Unified Parkinson's Disease Rating Scale. Results: bradykinetic and hypokinetic abnormalities are a frequent finding, especially in the oldest old. Over 50% of subjects aged 80 or over demonstrated at least one such sign. Only 10% of subjects had any recorded neurological disease. Conclusions: the frequency of recognized neurological and other disease is insufficient to account for the rate of subtle extrapyramidal abnormalities found. These findings may thus represent intrinsic age-related changes in neurological functioning, this being consistent with previously described pathological changes in the substantia nigra and striatum in normal ageing. ageing, neurological defiat, parkinsonism © 1998, British Geriatrics Society http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Age and Ageing Oxford University Press

Extrapyramidal signs in cognitively intact elderly people

Age and Ageing , Volume 27 (5) – Sep 1, 1998

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References (25)

Publisher
Oxford University Press
Copyright
© 1998, British Geriatrics Society
ISSN
0002-0729
eISSN
1468-2834
DOI
10.1093/ageing/27.5.557
Publisher site
See Article on Publisher Site

Abstract

Abstract Aim: to investigate the prevalence of extrapyramidal signs in elderly people and their relationship to disease. Setting and subjects: 151 non-demented subjects age 65 and over living within a defined geographical area in Nottingham who were participating in the MRC multicentre Cognitive Function and Ageing Study. Measurements: subjects were assessed at home. Extrapyramidal signs were rated according to a standardized neurological examination using items from the Unified Parkinson's Disease Rating Scale. Results: bradykinetic and hypokinetic abnormalities are a frequent finding, especially in the oldest old. Over 50% of subjects aged 80 or over demonstrated at least one such sign. Only 10% of subjects had any recorded neurological disease. Conclusions: the frequency of recognized neurological and other disease is insufficient to account for the rate of subtle extrapyramidal abnormalities found. These findings may thus represent intrinsic age-related changes in neurological functioning, this being consistent with previously described pathological changes in the substantia nigra and striatum in normal ageing. ageing, neurological defiat, parkinsonism © 1998, British Geriatrics Society

Journal

Age and AgeingOxford University Press

Published: Sep 1, 1998

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