Abstract

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By continuing to use our website, you are agreeing to our use of cookies. You can change your cookie settings at any time. Find out more Skip Navigation Oxford Journals Contact Us My Basket My Account JNCI Monographs About This Journal Contact This Journal Subscriptions View Current Issue (Volume 2015 Issue 51 May 2015) Archive Search Institution: :: Sign In as Personal Subscriber Oxford Journals Medicine & Health JNCI Monographs Volume 1998 Issue 23 Pp. 0vii-0viii. First National AIDS Malignancy Conference Monograph: Introduction Ellen Feigal * * Affiliation of author: Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD. Correspondence to: Ellen Feigal, M.D., National Institutes of Health, Bldg. 31, Rm. 3A44, Bethesda, MD 20892. Scientists, physicians, health care workers, and community and patient advocates from around the world gathered at the first national forum focused on acquired immunodeficiency syndrome (AIDS)-associated cancers in April 1997 on the grounds of the National Institutes of Health campus in Bethesda, MD. The first National AIDS Malignancy Conference, sponsored by the National Cancer Institute, featured multidisciplinary presentations on the epidemiology, biology, virology, immunology, and treatment of cancers in the setting of human immunodeficiency virus (HIV) infection. Cancers have been associated with HIV since the beginning of the epidemic in the late 1970s. With almost 1 million individuals infected with HIV across the United States and 10 million infected worldwide, AIDS-associated cancers offer a unique perspective on the interplay of viruses, immune dysregulation, and cancer pathogenesis. This monograph is a comprehensive compilation of papers from 18 plenary speakers. Overview of Cancers, Viruses, and Immunodeficiency Dr. Valerie Beral opened the conference with a presentation of the epidemiologic evidence on the effect of immunosuppression on cancer risk. Immunodeficiency, whether congenital, therapeutic, or infectious in origin, increases the risk of certain, but not all, types of cancer. A common feature of these cancers is that specific infectious agents appear to be important in their etiology. The study of cancer in immunodeficient populations offers a unique opportunity to investigate the role of the immune system in controlling the development, growth, and dissemination of tumors. Such studies have already contributed substantially to knowledge about the role of infectious agents in human cancer. Given the strategic role that infectious agents may have in the etiology of these cancers, Dr. Elliott Kieff discussed the molecular mechanisms by which human papillomavirus (HPV), Epstein-Barr virus (EBV), human herpesvirus type 8 (HHV-8), and HIV persist and effect changes in cell growth that result in malignancy. Pharmacologic strategies to inhibit the mechanisms by which these viruses cause … (Full Text of this Article) « Previous | Next Article » Table of Contents This Article J Natl Cancer Inst Monogr (1998) 1998 (23): 0vii-0viii. 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