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Is epidemiology ready for epigenetics?

Is epidemiology ready for epigenetics? Published by Oxford University Press on behalf of the International Epidemiological Association International Journal of Epidemiology 2012;41:5–9 The Author 2012; all rights reserved. doi:10.1093/ije/dys006 EDITORIAL 1 2 Caroline L Relton * and George Davey Smith 1 2 Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, NE1 3BZ and MRC Centre for Causal Analyses in Translational Epidemiology (CAiTE), University of Bristol, Bristol, BS8 2BN, UK *Corresponding author. Dr Caroline L Relton, Institute of Genetic Medicine, Newcastle University, Bioscience Centre, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK. E-mail: caroline.relton@newcastle.ac.uk The revellers depicted in the painting by the Dutch trajectory. As Gilbert notes, this was a paradigm- artist Judith Leyster (1609–60) (Figure 1) will not changing idea. Perturbation of this ‘genetic regula- have given epigenetics a passing thought. Little were tion’ thus alters development, with critical periods they to know that indulgences, such as drinking alco- when even minor events can have disproportion- hol and smoking, would be contributing to their ate importance and ‘far-reaching consequences’—a ‘exposome’ and marking their epigenome to poten- concept that resonates with the contemporary tially compromise their future health. The skeleton Developmental Origins of Health and Disease hypoth- esis. As highlighted by Jablonka and Lamm http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Journal of Epidemiology Oxford University Press

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References (45)

Publisher
Oxford University Press
Copyright
Published by Oxford University Press on behalf of the International Epidemiological Association The Author 2012; all rights reserved.
ISSN
0300-5771
eISSN
1464-3685
DOI
10.1093/ije/dys006
pmid
22422447
Publisher site
See Article on Publisher Site

Abstract

Published by Oxford University Press on behalf of the International Epidemiological Association International Journal of Epidemiology 2012;41:5–9 The Author 2012; all rights reserved. doi:10.1093/ije/dys006 EDITORIAL 1 2 Caroline L Relton * and George Davey Smith 1 2 Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, NE1 3BZ and MRC Centre for Causal Analyses in Translational Epidemiology (CAiTE), University of Bristol, Bristol, BS8 2BN, UK *Corresponding author. Dr Caroline L Relton, Institute of Genetic Medicine, Newcastle University, Bioscience Centre, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK. E-mail: caroline.relton@newcastle.ac.uk The revellers depicted in the painting by the Dutch trajectory. As Gilbert notes, this was a paradigm- artist Judith Leyster (1609–60) (Figure 1) will not changing idea. Perturbation of this ‘genetic regula- have given epigenetics a passing thought. Little were tion’ thus alters development, with critical periods they to know that indulgences, such as drinking alco- when even minor events can have disproportion- hol and smoking, would be contributing to their ate importance and ‘far-reaching consequences’—a ‘exposome’ and marking their epigenome to poten- concept that resonates with the contemporary tially compromise their future health. The skeleton Developmental Origins of Health and Disease hypoth- esis. As highlighted by Jablonka and Lamm

Journal

International Journal of EpidemiologyOxford University Press

Published: Feb 14, 2012

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