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Natural History of Anal vs Oral HPV Infection in HIV-Infected Men and Women

Natural History of Anal vs Oral HPV Infection in HIV-Infected Men and Women Background.Human immunodeficiency virus (HIV)infected individuals are at greater risk for human papillomavirus (HPV)associated anal than oropharyngeal cancers. The prevalence of anal vs oral HPV infections is higher in this population, but whether this is explained by higher incidence or persistence is unknown.Methods.Oral rinse and anal swab samples were collected semiannually from 404 HIV-infected adults in Baltimore, Maryland. Samples were tested for 37 HPV types using PGMY09/11 primers and reverse line-blot hybridization. Risk factors for HPV persistence were explored using adjusted Wei-Lin-Weissfeld models.Results.The prevalence (84 vs 28), incidence (145 vs 31 per 1000 person-months), and 12-month persistence (54 vs 29) were higher for anal vs oral HPV infections, respectively (each P < .001). Heterosexual men had lower incidence of anal HPV than men who have sex with men and women, but a higher incidence of oral HPV infection (test of interaction P < 0.001). In adjusted analyses, risk factors for HPV persistence included prevalent vs incident (adjusted hazard ratio [aHR] 4.0; 95 confidence interval [CI], 3.54.8) and anal vs oral HPV infections (aHR 1.5; 95 CI, 1.21.9).Conclusions.The higher incidence and persistence of anal vs oral HPV infections likely contributes to the higher burden of anal as compared to oral HPV-associated cancers in HIV-infected individuals. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Infectious Diseases Oxford University Press

Natural History of Anal vs Oral HPV Infection in HIV-Infected Men and Women

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References (40)

Publisher
Oxford University Press
Copyright
The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
Subject
MAJOR ARTICLES AND BRIEF REPORTS
ISSN
0022-1899
eISSN
1537-6613
DOI
10.1093/infdis/jit170
pmid
23596319
Publisher site
See Article on Publisher Site

Abstract

Background.Human immunodeficiency virus (HIV)infected individuals are at greater risk for human papillomavirus (HPV)associated anal than oropharyngeal cancers. The prevalence of anal vs oral HPV infections is higher in this population, but whether this is explained by higher incidence or persistence is unknown.Methods.Oral rinse and anal swab samples were collected semiannually from 404 HIV-infected adults in Baltimore, Maryland. Samples were tested for 37 HPV types using PGMY09/11 primers and reverse line-blot hybridization. Risk factors for HPV persistence were explored using adjusted Wei-Lin-Weissfeld models.Results.The prevalence (84 vs 28), incidence (145 vs 31 per 1000 person-months), and 12-month persistence (54 vs 29) were higher for anal vs oral HPV infections, respectively (each P < .001). Heterosexual men had lower incidence of anal HPV than men who have sex with men and women, but a higher incidence of oral HPV infection (test of interaction P < 0.001). In adjusted analyses, risk factors for HPV persistence included prevalent vs incident (adjusted hazard ratio [aHR] 4.0; 95 confidence interval [CI], 3.54.8) and anal vs oral HPV infections (aHR 1.5; 95 CI, 1.21.9).Conclusions.The higher incidence and persistence of anal vs oral HPV infections likely contributes to the higher burden of anal as compared to oral HPV-associated cancers in HIV-infected individuals.

Journal

The Journal of Infectious DiseasesOxford University Press

Published: Jul 15, 2013

Keywords: oral HPV anal HPV HIV natural history persistence risk factors incidence variably detected

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