Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

New Guidelines to Evaluate the Response to Treatment in Solid Tumors

New Guidelines to Evaluate the Response to Treatment in Solid Tumors Anticancer cytotoxic agents go through a process by which their antitumor activity—on thebasisof the amount of tumor shrinkage they could generate—has been investigated. In the late1970s,the International Union Against Cancer and the World Health Organization introduced specificcriteriafor the codification of tumor response evaluation. In 1994, several organizations involved inclinicalresearch combined forces to tackle the review of these criteria on the basis of the experience andknowledge acquired since then. After several years of intensive discussions, a new set ofguidelines isready that will supersede the former criteria. In parallel to this initiative, one of the participatinggroupsdeveloped a model by which response rates could be derived from unidimensional measurement oftumor lesions instead of the usual bidimensional approach. This new concept has been largelyvalidatedby the Response Evaluation Criteria in Solid Tumors Group and integrated into the presentguidelines.This special article also provides some philosophic background to clarify the various purposes ofresponse evaluation. It proposes a model by which a combined assessment of all existing lesions,characterized by target lesions (to be measured) and nontarget lesions, is used to extrapolate anoverallresponse to treatment. Methods of assessing tumor lesions are better codified, briefly within theguidelines and in more detail in Appendix I. All other aspects of response evaluation have beendiscussed, reviewed, and amended whenever appropriate. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of the National Cancer Institute Oxford University Press

Loading next page...
 
/lp/oxford-university-press/new-guidelines-to-evaluate-the-response-to-treatment-in-solid-tumors-X9deA0tAYj

References (31)

Publisher
Oxford University Press
Copyright
Oxford University Press
ISSN
0027-8874
eISSN
1460-2105
DOI
10.1093/jnci/92.3.205
Publisher site
See Article on Publisher Site

Abstract

Anticancer cytotoxic agents go through a process by which their antitumor activity—on thebasisof the amount of tumor shrinkage they could generate—has been investigated. In the late1970s,the International Union Against Cancer and the World Health Organization introduced specificcriteriafor the codification of tumor response evaluation. In 1994, several organizations involved inclinicalresearch combined forces to tackle the review of these criteria on the basis of the experience andknowledge acquired since then. After several years of intensive discussions, a new set ofguidelines isready that will supersede the former criteria. In parallel to this initiative, one of the participatinggroupsdeveloped a model by which response rates could be derived from unidimensional measurement oftumor lesions instead of the usual bidimensional approach. This new concept has been largelyvalidatedby the Response Evaluation Criteria in Solid Tumors Group and integrated into the presentguidelines.This special article also provides some philosophic background to clarify the various purposes ofresponse evaluation. It proposes a model by which a combined assessment of all existing lesions,characterized by target lesions (to be measured) and nontarget lesions, is used to extrapolate anoverallresponse to treatment. Methods of assessing tumor lesions are better codified, briefly within theguidelines and in more detail in Appendix I. All other aspects of response evaluation have beendiscussed, reviewed, and amended whenever appropriate.

Journal

Journal of the National Cancer InstituteOxford University Press

Published: Feb 2, 2000

There are no references for this article.