Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Prevalence and level of antibodies to the circumsporozoite proteins of human malaria parasites, including a variant of Plasmodium vivax, in the population of two epidemiologically distinct areas in the state of Acre, Brazil

Prevalence and level of antibodies to the circumsporozoite proteins of human malaria parasites,... Abstract A seroepidemiological study of the prevalence of antibodies against the repeating epitopes of circumsporozoite (CS) proteins of human malaria parasites was conducted in 2 different areas in the state of Acre, Brazil in 1987 and 1990. In 1987 antibodies against the CS protein of the VK 247 variant Plasmodium vivax as well as antibodies against the CS proteins of P. falciparum and the classic P. vivax were found at relatively high rates in the 2 areas, but significant microepidemiological differences were observed. In 1990, when large scale migration in Amazonia had ceased and control measures were applied in the study areas, the malaria endemicity decreased, as determined by the declining prevalence of anti-sporozoite antibodies against all Plasmodium species, and the small number of individuals with positive blood smears. Antibodies against sporozoites of the variant P. vivax did not cross-react with the CS proteins of the classic P. vivax, nor with antibodies against sporozoites of P. falciparum and P. malariae. Sera containing antibodies against the CS protein of P. malariae were found at a very low frequency, and only in 1987. The anti-CS protein antibody response to all Plasmodium species was age-related. References Cochrane et al., 1990 Cochrane A.H. , Nardin E.H. , de Arruda M. , Maracic M. , Clavijo P. , Collins W.E. , Nussenzweig R.S. . Widespread reactivity of human sera with a variant repeat of the circumsporpzoite protein of Plasmodium vivax , American Journal of Tropical Medicine and Hygiene , 1990 , vol. 43 (pg. 446 - 451 ) Google Scholar PubMed OpenURL Placeholder Text WorldCat Cruz Marques, 1986 Cruz Marques A. . Migrations and the dissemination of malaria in Brazil , Memorias do Instituto Oswaldo Cruz , 1986 , vol. 81 supplement 2 (pg. 17 - 30 ) Google Scholar Crossref Search ADS PubMed WorldCat Cruz Marques, 1987 Cruz Marques A. . Human migration and the spread of malaria in Brazil , Parasitology Today , 1987 , vol. 3 (pg. 166 - 170 ) Google Scholar Crossref Search ADS PubMed WorldCat De Arruda et al., 1986 De Arruda M. , Carvalho M.B. , Nussenzweig R.S. , Maracic M. , Ferreira A.W. , Cochrane A.H. . Potential vectors of malaria and their different susceptibility to Plasmodium falciparum and Plasmodium vivax in northern Brazil identified by immunoassay , American Journal of Tropical Medicine and Hygiene , 1986 , vol. 35 (pg. 873 - 881 ) Google Scholar PubMed OpenURL Placeholder Text WorldCat De Arruda et al., 1989 De Arruda M. , Nardin E.H. , Nussenzweig R.S. , Cochrane A.H. . Seroepidemiological studies of malaria in Indian tribes and in monkeys of Amazon basin of Brazil , American Journal of Tropical Medicine and Hygiene , 1989 , vol. 41 (pg. 379 - 385 ) Google Scholar PubMed OpenURL Placeholder Text WorldCat Druilhe et al., 1986 Druilhe P. , Pradier O. , Marc J.P. , Miltgen F. , Mazier D. , Parent G. . Levels of antibodies to Plasmodium falciparum sporozoite surface antigens reflect malaria transmission rates and are persistent in the absence of reinfection , Infection and Immunity , 1986 , vol. 53 (pg. 393 - 397 ) Google Scholar PubMed OpenURL Placeholder Text WorldCat Enea et al., 1984 Enea V. , Ellis J. , Zavala F. , Arnot D.E. , Asavanich A. , Masuda A. , Quakyi I. , Nussenzweig R.S. . DNA cloning of Plasmodium falciparum circumsporozoite gene: amino acid sequence of repetitive epitopes , Science , 1984 , vol. 86 (pg. 628 - 630 ) Google Scholar Crossref Search ADS WorldCat Greenwood, 1990 Greenwood B.M. . Immune responses to sporozoite antigens and their relationship to naturally acquired immunity to malaria , Bulletin of the World Health Organization , 1990 , vol. 68 (pg. 184 - 190 ) supplement Google Scholar PubMed OpenURL Placeholder Text WorldCat Kremsner et al., 1989 Kremsner P.G. , Zotter G.M. , Feldmeier H. , Bienzle U. , Jansen-Rosseck R. , Graninger W. , Rocha R.M. , Wernsdorfer W.H. . Differences in drug response of Plasmodium falciparum within an area of the Amazon region , Transactions of the Royal Society of Tropical Medicine and Hygiene , 1989 , vol. 83 (pg. 158 - 161 ) Google Scholar Crossref Search ADS PubMed WorldCat Lal et al., 1988 Lal A.A. , de la Cruz V.F. , Campbell G.H. , Procell P.M. , Collins W.E. , McCutchan T.F. . Structure of the circumsporozoite gene of Plasmodium malariae , Molecular and Biochemical Parasitology , 1988 , vol. 30 (pg. 291 - 294 ) Google Scholar Crossref Search ADS PubMed WorldCat Nardin et al., 1979 Nardin E.H. , Nussenzweig R.S. , McGregor I.A. , Bryan J.H. . Antibodies to sporozoites: their frequent occurence in individuals living in an area of hyperendemic malaria , Science , 1979 , vol. 86 (pg. 597 - 599 ) Google Scholar Crossref Search ADS WorldCat Pessi et al., 1990 Pessi A. , Michel M. , Bianchi E. , Mendis A. , Tougne C. , Verdini A.S. , Lambert H.L. , Carter R. , Mendis K. , Del Giudice G. . Use of synthetic peptides in the study of the antibody response to Plasmodium vivax sporozoites , American Journal of Tropical Medicine and Hygiene , 1990 , vol. 42 (pg. 17 - 23 ) Google Scholar PubMed OpenURL Placeholder Text WorldCat Rosenberg et al., 1989 Rosenberg R. , Wirtz R.A. , Lanar D.E. , Sattabongkot J. , Tall T. , Waters A.P. , Prasittisuk C. . Circumsporozoite protein heterogeneity in the human malaria parasite Plasmodium vivax , Science , 1989 , vol. 86 (pg. 973 - 976 ) Google Scholar Crossref Search ADS WorldCat Zavala et al., 1986 Zavala F. , Tam J. , Masuda M. . Synthetic peptides as antigens for the detection of humoral immunity to Plasmodium falciparum sporozoites , Journal of Immunological Methods , 1986 , vol. 93 (pg. 55 - 61 ) Google Scholar Crossref Search ADS PubMed WorldCat This content is only available as a PDF. Author notes Malaria http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Transactions of The Royal Society of Tropical Medicine and Hygiene Oxford University Press

Prevalence and level of antibodies to the circumsporozoite proteins of human malaria parasites, including a variant of Plasmodium vivax, in the population of two epidemiologically distinct areas in the state of Acre, Brazil

Loading next page...
 
/lp/oxford-university-press/prevalence-and-level-of-antibodies-to-the-circumsporozoite-proteins-of-kHfRAwZ0yk

References (14)

Publisher
Oxford University Press
ISSN
0035-9203
eISSN
1878-3503
DOI
10.1016/0035-9203(92)90423-A
Publisher site
See Article on Publisher Site

Abstract

Abstract A seroepidemiological study of the prevalence of antibodies against the repeating epitopes of circumsporozoite (CS) proteins of human malaria parasites was conducted in 2 different areas in the state of Acre, Brazil in 1987 and 1990. In 1987 antibodies against the CS protein of the VK 247 variant Plasmodium vivax as well as antibodies against the CS proteins of P. falciparum and the classic P. vivax were found at relatively high rates in the 2 areas, but significant microepidemiological differences were observed. In 1990, when large scale migration in Amazonia had ceased and control measures were applied in the study areas, the malaria endemicity decreased, as determined by the declining prevalence of anti-sporozoite antibodies against all Plasmodium species, and the small number of individuals with positive blood smears. Antibodies against sporozoites of the variant P. vivax did not cross-react with the CS proteins of the classic P. vivax, nor with antibodies against sporozoites of P. falciparum and P. malariae. Sera containing antibodies against the CS protein of P. malariae were found at a very low frequency, and only in 1987. The anti-CS protein antibody response to all Plasmodium species was age-related. References Cochrane et al., 1990 Cochrane A.H. , Nardin E.H. , de Arruda M. , Maracic M. , Clavijo P. , Collins W.E. , Nussenzweig R.S. . Widespread reactivity of human sera with a variant repeat of the circumsporpzoite protein of Plasmodium vivax , American Journal of Tropical Medicine and Hygiene , 1990 , vol. 43 (pg. 446 - 451 ) Google Scholar PubMed OpenURL Placeholder Text WorldCat Cruz Marques, 1986 Cruz Marques A. . Migrations and the dissemination of malaria in Brazil , Memorias do Instituto Oswaldo Cruz , 1986 , vol. 81 supplement 2 (pg. 17 - 30 ) Google Scholar Crossref Search ADS PubMed WorldCat Cruz Marques, 1987 Cruz Marques A. . Human migration and the spread of malaria in Brazil , Parasitology Today , 1987 , vol. 3 (pg. 166 - 170 ) Google Scholar Crossref Search ADS PubMed WorldCat De Arruda et al., 1986 De Arruda M. , Carvalho M.B. , Nussenzweig R.S. , Maracic M. , Ferreira A.W. , Cochrane A.H. . Potential vectors of malaria and their different susceptibility to Plasmodium falciparum and Plasmodium vivax in northern Brazil identified by immunoassay , American Journal of Tropical Medicine and Hygiene , 1986 , vol. 35 (pg. 873 - 881 ) Google Scholar PubMed OpenURL Placeholder Text WorldCat De Arruda et al., 1989 De Arruda M. , Nardin E.H. , Nussenzweig R.S. , Cochrane A.H. . Seroepidemiological studies of malaria in Indian tribes and in monkeys of Amazon basin of Brazil , American Journal of Tropical Medicine and Hygiene , 1989 , vol. 41 (pg. 379 - 385 ) Google Scholar PubMed OpenURL Placeholder Text WorldCat Druilhe et al., 1986 Druilhe P. , Pradier O. , Marc J.P. , Miltgen F. , Mazier D. , Parent G. . Levels of antibodies to Plasmodium falciparum sporozoite surface antigens reflect malaria transmission rates and are persistent in the absence of reinfection , Infection and Immunity , 1986 , vol. 53 (pg. 393 - 397 ) Google Scholar PubMed OpenURL Placeholder Text WorldCat Enea et al., 1984 Enea V. , Ellis J. , Zavala F. , Arnot D.E. , Asavanich A. , Masuda A. , Quakyi I. , Nussenzweig R.S. . DNA cloning of Plasmodium falciparum circumsporozoite gene: amino acid sequence of repetitive epitopes , Science , 1984 , vol. 86 (pg. 628 - 630 ) Google Scholar Crossref Search ADS WorldCat Greenwood, 1990 Greenwood B.M. . Immune responses to sporozoite antigens and their relationship to naturally acquired immunity to malaria , Bulletin of the World Health Organization , 1990 , vol. 68 (pg. 184 - 190 ) supplement Google Scholar PubMed OpenURL Placeholder Text WorldCat Kremsner et al., 1989 Kremsner P.G. , Zotter G.M. , Feldmeier H. , Bienzle U. , Jansen-Rosseck R. , Graninger W. , Rocha R.M. , Wernsdorfer W.H. . Differences in drug response of Plasmodium falciparum within an area of the Amazon region , Transactions of the Royal Society of Tropical Medicine and Hygiene , 1989 , vol. 83 (pg. 158 - 161 ) Google Scholar Crossref Search ADS PubMed WorldCat Lal et al., 1988 Lal A.A. , de la Cruz V.F. , Campbell G.H. , Procell P.M. , Collins W.E. , McCutchan T.F. . Structure of the circumsporozoite gene of Plasmodium malariae , Molecular and Biochemical Parasitology , 1988 , vol. 30 (pg. 291 - 294 ) Google Scholar Crossref Search ADS PubMed WorldCat Nardin et al., 1979 Nardin E.H. , Nussenzweig R.S. , McGregor I.A. , Bryan J.H. . Antibodies to sporozoites: their frequent occurence in individuals living in an area of hyperendemic malaria , Science , 1979 , vol. 86 (pg. 597 - 599 ) Google Scholar Crossref Search ADS WorldCat Pessi et al., 1990 Pessi A. , Michel M. , Bianchi E. , Mendis A. , Tougne C. , Verdini A.S. , Lambert H.L. , Carter R. , Mendis K. , Del Giudice G. . Use of synthetic peptides in the study of the antibody response to Plasmodium vivax sporozoites , American Journal of Tropical Medicine and Hygiene , 1990 , vol. 42 (pg. 17 - 23 ) Google Scholar PubMed OpenURL Placeholder Text WorldCat Rosenberg et al., 1989 Rosenberg R. , Wirtz R.A. , Lanar D.E. , Sattabongkot J. , Tall T. , Waters A.P. , Prasittisuk C. . Circumsporozoite protein heterogeneity in the human malaria parasite Plasmodium vivax , Science , 1989 , vol. 86 (pg. 973 - 976 ) Google Scholar Crossref Search ADS WorldCat Zavala et al., 1986 Zavala F. , Tam J. , Masuda M. . Synthetic peptides as antigens for the detection of humoral immunity to Plasmodium falciparum sporozoites , Journal of Immunological Methods , 1986 , vol. 93 (pg. 55 - 61 ) Google Scholar Crossref Search ADS PubMed WorldCat This content is only available as a PDF. Author notes Malaria

Journal

Transactions of The Royal Society of Tropical Medicine and HygieneOxford University Press

Published: Jan 1, 1992

There are no references for this article.