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Relationship between white blood cell count and incident hypertension*

Relationship between white blood cell count and incident hypertension* Background:Elevated white blood cell (WBC) count is considered to be prospectively associated with cardiovascular disease. However, its relationship to hypertension, independent of smoking and other established cardiovascular risk factors, is not clear, especially among women.Methods:We used data from a large population-based study in Wisconsin (Beaver Dam Eye study) to examine the prospective association between elevated WBC count and incident hypertension among 2459 hypertension-free women (48.6%) and men (51.4%) after adjusting for, and stratifying by smoking and several other potential confounding factors.Results:In multivariable proportional hazards models, increasing tertiles of WBC count was associated with increased risk ratios (RR) of hypertension in the whole cohort (WBC count tertiles 1–3; RR 1, 1.2, 1.7; P < .01), and separately among women (WBC count tertiles 1–3; RR 1, 1.1, 1.4; P < .05) and men (WBC count tertiles 1–3; RR 1, 1.3, 1.9; P < .01). Results from subsequent analyses stratified by smoking and several other related factors were consistent with this finding.Conclusions:Elevated WBC count is associated with incident hypertension among women and men independent of smoking and most traditional cardiovascular risk factors in this predominantly white cohort. Further research is required to determine whether this association is true among racial minorities (eg, African Americans), and independent of C-reactive protein, a more specific marker of inflammation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Hypertension Oxford University Press

Relationship between white blood cell count and incident hypertension*

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References (32)

Publisher
Oxford University Press
Copyright
© 2004 by the American Journal of Hypertension, Ltd.
ISSN
0895-7061
eISSN
1941-7225
DOI
10.1016/j.amjhyper.2003.11.005
pmid
15001197
Publisher site
See Article on Publisher Site

Abstract

Background:Elevated white blood cell (WBC) count is considered to be prospectively associated with cardiovascular disease. However, its relationship to hypertension, independent of smoking and other established cardiovascular risk factors, is not clear, especially among women.Methods:We used data from a large population-based study in Wisconsin (Beaver Dam Eye study) to examine the prospective association between elevated WBC count and incident hypertension among 2459 hypertension-free women (48.6%) and men (51.4%) after adjusting for, and stratifying by smoking and several other potential confounding factors.Results:In multivariable proportional hazards models, increasing tertiles of WBC count was associated with increased risk ratios (RR) of hypertension in the whole cohort (WBC count tertiles 1–3; RR 1, 1.2, 1.7; P < .01), and separately among women (WBC count tertiles 1–3; RR 1, 1.1, 1.4; P < .05) and men (WBC count tertiles 1–3; RR 1, 1.3, 1.9; P < .01). Results from subsequent analyses stratified by smoking and several other related factors were consistent with this finding.Conclusions:Elevated WBC count is associated with incident hypertension among women and men independent of smoking and most traditional cardiovascular risk factors in this predominantly white cohort. Further research is required to determine whether this association is true among racial minorities (eg, African Americans), and independent of C-reactive protein, a more specific marker of inflammation.

Journal

American Journal of HypertensionOxford University Press

Published: Mar 1, 2004

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