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Therapeutic Efficacy of 29 Antimicrobial Regimens in Experimental Intraabdominal Sepsis

Therapeutic Efficacy of 29 Antimicrobial Regimens in Experimental Intraabdominal Sepsis Abstract An animal model of colonic perforation was used to examine the efficacy of 29 antimicrobial regimens in the treatment of intraabdominal sepsis. Efficacy was judged on mortality during the first 12 days after challenge and on the incidence of intraabdominal abscess noted at necropsy upon completion of the experiment. In general, antimicrobial agents that are active against coliform bacteria prevented early mortality, whereas drugs that are active against Bacteroides fragilis were most effective in reducing the incidence of late abscess formation. Exceptions were metronidazole, which produced a significant reduction in early mortality, and chloramphenicol, which caused only a modest reduction in the incidence of abscess. Optimal results were obtained with several regimens that showed good in vitro activity against both coliforms and B. fragilis. This content is only available as a PDF. © 1981 by The University of Chicago http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Infectious Diseases Oxford University Press

Therapeutic Efficacy of 29 Antimicrobial Regimens in Experimental Intraabdominal Sepsis

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References (20)

Publisher
Oxford University Press
Copyright
© 1981 by The University of Chicago
ISSN
1058-4838
eISSN
1537-6591
DOI
10.1093/clinids/3.3.535
Publisher site
See Article on Publisher Site

Abstract

Abstract An animal model of colonic perforation was used to examine the efficacy of 29 antimicrobial regimens in the treatment of intraabdominal sepsis. Efficacy was judged on mortality during the first 12 days after challenge and on the incidence of intraabdominal abscess noted at necropsy upon completion of the experiment. In general, antimicrobial agents that are active against coliform bacteria prevented early mortality, whereas drugs that are active against Bacteroides fragilis were most effective in reducing the incidence of late abscess formation. Exceptions were metronidazole, which produced a significant reduction in early mortality, and chloramphenicol, which caused only a modest reduction in the incidence of abscess. Optimal results were obtained with several regimens that showed good in vitro activity against both coliforms and B. fragilis. This content is only available as a PDF. © 1981 by The University of Chicago

Journal

Clinical Infectious DiseasesOxford University Press

Published: May 1, 1981

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