Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Trends in Carbapenem Susceptibility of Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumoniae Isolates From Long-Term Acute Care Hospitals Across the United States-An Analysis of Antibiograms

Trends in Carbapenem Susceptibility of Acinetobacter baumannii, Pseudomonas aeruginosa and... IDWEEK 2015 POSTER ABSTRACTS 177. Trends in Carbapenem Susceptibility of Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumoniae Isolates From Long- Term Acute Care Hospitals Across the United States-An Analysis of Antibiograms 1 2 3 Sukhesh Sudan, MPH ; Christina Cherian, MD ; E. Goldstein, MD, RM ; David 4 5 6 1 W. Hines, MD ; George Glenn, MS ; Teena Chopra, MD, MPH ; Department of Family Medicine and Public Health Sciences, Wayne State University, Detroit, 2 3 Michigan; Wayne State University, Detroit, Michigan; Alden Laboratory, Santa Monica, California; Metro Infectious Disease Consultants, LLC, Hinsdale, Illinois; 5 6 Area Director of Laboratory Services, Chicago, Illinois; Infectious Diseases, Detroit Medical Center/Wayne State University, Detroit, Michigan Session: 42. Antimicrobial Stewardship: Current State and Future Opportunities Thursday, October 8, 2015: 12:30 PM Background. The use of carbapenems has become increasingly common and there is lack of information of their susceptibilities in long-term acute care hospitals (LTACHs). The aim of this study is to analyze the trends in susceptibility of common bacteria including Acinetobacter baumannii (AB), Klebsiella pneumonia (KP) and Pseudomonas aeruginosa (PA) to carbapenems in three long-term acute care hospitals in United States. Methods. Minimum inhibitory concentrations (MICs) of carbapenems including imipenem to three MDROs including AB, KP, and PA was retrieved from the micro- biology database of three LTACHs in United States from 2008 to 2014. The χ test was used to calculate the p-value. Results. There was a decrease in susceptibility to imipenem at all the three LTACHs during the study period. The susceptibility of PA isolates to imipenem de- creased from 71% in 2008 to 45% in 2014 (p < .001, OR = 2.94, 95% CI 1.7– 5.1) at LTACH 1, changed from 40% in 2011 to 44% in 2014 at LTACH 2 and 30% in 2008 to 45% in 2014 at LTACH 3 (figure 1). The susceptibility of KP isolates to imipenem changed from 56% in 2010 to 71% in 2014 at LTACH 1, decreased from 78% in 2009 to 58% in 2013 at LTACH 2 and 98% in 2008 to 57% in 2014 (p < .001, OR = 1.72, CI 1.47–2.01) at LTACH 3 (figure 2). The susceptibility of AB isolates to imipenem were reportedly low during the study period at all the three LTACHs ranging from 0% to 34% (figure 3). Conclusion. Given the dwindling antimicrobial pipeline and slow pace of R & D to develop new drugs, it is pertinent to preserve the limited drugs available for treatment of MDROs. Implementation of antimicrobial stewardship programs at LTACHs and making antibiograms available to infection control personnel is warranted. Disclosures. All authors: No reported disclosures. Open Forum Infectious Diseases 2015;2:71–536 © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/ by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com. DOI: 10.1093/ofid/ofv133 Poster Abstracts OFID 2015:2 (Suppl 1) S71 � � http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Open Forum Infectious Diseases Pubmed Central

Trends in Carbapenem Susceptibility of Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumoniae Isolates From Long-Term Acute Care Hospitals Across the United States-An Analysis of Antibiograms

Open Forum Infectious Diseases , Volume 2 (Suppl 1) – Dec 9, 2015

Loading next page...
 
/lp/pubmed-central/trends-in-carbapenem-susceptibility-of-acinetobacter-baumannii-lFCzKQ0swF

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
Pubmed Central
Copyright
© The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America
ISSN
2328-8957
eISSN
2328-8957
DOI
10.1093/ofid/ofv133.54
Publisher site
See Article on Publisher Site

Abstract

IDWEEK 2015 POSTER ABSTRACTS 177. Trends in Carbapenem Susceptibility of Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumoniae Isolates From Long- Term Acute Care Hospitals Across the United States-An Analysis of Antibiograms 1 2 3 Sukhesh Sudan, MPH ; Christina Cherian, MD ; E. Goldstein, MD, RM ; David 4 5 6 1 W. Hines, MD ; George Glenn, MS ; Teena Chopra, MD, MPH ; Department of Family Medicine and Public Health Sciences, Wayne State University, Detroit, 2 3 Michigan; Wayne State University, Detroit, Michigan; Alden Laboratory, Santa Monica, California; Metro Infectious Disease Consultants, LLC, Hinsdale, Illinois; 5 6 Area Director of Laboratory Services, Chicago, Illinois; Infectious Diseases, Detroit Medical Center/Wayne State University, Detroit, Michigan Session: 42. Antimicrobial Stewardship: Current State and Future Opportunities Thursday, October 8, 2015: 12:30 PM Background. The use of carbapenems has become increasingly common and there is lack of information of their susceptibilities in long-term acute care hospitals (LTACHs). The aim of this study is to analyze the trends in susceptibility of common bacteria including Acinetobacter baumannii (AB), Klebsiella pneumonia (KP) and Pseudomonas aeruginosa (PA) to carbapenems in three long-term acute care hospitals in United States. Methods. Minimum inhibitory concentrations (MICs) of carbapenems including imipenem to three MDROs including AB, KP, and PA was retrieved from the micro- biology database of three LTACHs in United States from 2008 to 2014. The χ test was used to calculate the p-value. Results. There was a decrease in susceptibility to imipenem at all the three LTACHs during the study period. The susceptibility of PA isolates to imipenem de- creased from 71% in 2008 to 45% in 2014 (p < .001, OR = 2.94, 95% CI 1.7– 5.1) at LTACH 1, changed from 40% in 2011 to 44% in 2014 at LTACH 2 and 30% in 2008 to 45% in 2014 at LTACH 3 (figure 1). The susceptibility of KP isolates to imipenem changed from 56% in 2010 to 71% in 2014 at LTACH 1, decreased from 78% in 2009 to 58% in 2013 at LTACH 2 and 98% in 2008 to 57% in 2014 (p < .001, OR = 1.72, CI 1.47–2.01) at LTACH 3 (figure 2). The susceptibility of AB isolates to imipenem were reportedly low during the study period at all the three LTACHs ranging from 0% to 34% (figure 3). Conclusion. Given the dwindling antimicrobial pipeline and slow pace of R & D to develop new drugs, it is pertinent to preserve the limited drugs available for treatment of MDROs. Implementation of antimicrobial stewardship programs at LTACHs and making antibiograms available to infection control personnel is warranted. Disclosures. All authors: No reported disclosures. Open Forum Infectious Diseases 2015;2:71–536 © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/ by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com. DOI: 10.1093/ofid/ofv133 Poster Abstracts OFID 2015:2 (Suppl 1) S71 � �

Journal

Open Forum Infectious DiseasesPubmed Central

Published: Dec 9, 2015

There are no references for this article.