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Androgen receptor gene CAG and GGC repeat lengths in cryptorchidism.

Androgen receptor gene CAG and GGC repeat lengths in cryptorchidism. Cryptorchidism is the most common congenital birth defect in male children, and accumulating evidence suggests that genetic abnormalities may be associated with it. The androgen receptor has two polymorphic sites in exon 1, with different numbers of CAG and GGC repeats, resulting in variable lengths of polyglutamine and polyglycine stretches. Longer CAG repeats result in a reduced androgen receptor transcriptional activity, but the role of the GGC triplets is less clear. In this study we analysed CAG and GGC repeat lengths in men with a history of cryptorchidism, associated or not with impairment of sperm production, in comparison with normal fertile subjects. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Endocrinology Pubmed

Androgen receptor gene CAG and GGC repeat lengths in cryptorchidism.

European Journal of Endocrinology , Volume 152 (3): 7 – Apr 19, 2005

Androgen receptor gene CAG and GGC repeat lengths in cryptorchidism.


Abstract

Cryptorchidism is the most common congenital birth defect in male children, and accumulating evidence suggests that genetic abnormalities may be associated with it. The androgen receptor has two polymorphic sites in exon 1, with different numbers of CAG and GGC repeats, resulting in variable lengths of polyglutamine and polyglycine stretches. Longer CAG repeats result in a reduced androgen receptor transcriptional activity, but the role of the GGC triplets is less clear. In this study we analysed CAG and GGC repeat lengths in men with a history of cryptorchidism, associated or not with impairment of sperm production, in comparison with normal fertile subjects.

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ISSN
0804-4643
DOI
10.1530/eje.1.01860
pmid
15757859
Publisher site
See Article on Publisher Site

Abstract

Cryptorchidism is the most common congenital birth defect in male children, and accumulating evidence suggests that genetic abnormalities may be associated with it. The androgen receptor has two polymorphic sites in exon 1, with different numbers of CAG and GGC repeats, resulting in variable lengths of polyglutamine and polyglycine stretches. Longer CAG repeats result in a reduced androgen receptor transcriptional activity, but the role of the GGC triplets is less clear. In this study we analysed CAG and GGC repeat lengths in men with a history of cryptorchidism, associated or not with impairment of sperm production, in comparison with normal fertile subjects.

Journal

European Journal of EndocrinologyPubmed

Published: Apr 19, 2005

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