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Characterization of a New HIV-1 CRF01_AE/CRF07_BC Recombinant Virus in Guangxi, China.

Characterization of a New HIV-1 CRF01_AE/CRF07_BC Recombinant Virus in Guangxi, China. Currently, more and more kinds of circulating recombinant forms (CRFs) and unique recombinant forms (URFs) were identified in China. A novel second-generation CCR5-tropic HIV-1 recombinant virus (GX2016EU09) was identified here, which was isolated from a HIV-1-infected man who had sex with men (MSM) in Guangxi, China. Phylogenetic analysis of near full-length genome (NFLG) showed that the novel HIV-1 recombinant GX2016EU09 clustered with CRF01_AE reference sequences, but set up a distinct branch. Recombinant analysis showed that the NFLG of GX2016EU09 composed of CRF01_AE (as the backbone) and CRF07_BC, with nine recombination break points observed in the gag, pol, vif, vpr, tat, rev, vpu, env, and nef regions. To our knowledge, this HIV-1 URF differs from previously documented CRF01_AE/CRF07_BC forms. The emergence of a novel CRF01_AE/CRF07_BC recombinant strain indicates the increasing complexity of the HIV-1 epidemic among the MSM group in Guangxi, China. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AIDS research and human retroviruses Pubmed

Characterization of a New HIV-1 CRF01_AE/CRF07_BC Recombinant Virus in Guangxi, China.

AIDS research and human retroviruses , Volume 33 (11): 5 – Jun 4, 2018

Characterization of a New HIV-1 CRF01_AE/CRF07_BC Recombinant Virus in Guangxi, China.


Abstract

Currently, more and more kinds of circulating recombinant forms (CRFs) and unique recombinant forms (URFs) were identified in China. A novel second-generation CCR5-tropic HIV-1 recombinant virus (GX2016EU09) was identified here, which was isolated from a HIV-1-infected man who had sex with men (MSM) in Guangxi, China. Phylogenetic analysis of near full-length genome (NFLG) showed that the novel HIV-1 recombinant GX2016EU09 clustered with CRF01_AE reference sequences, but set up a distinct branch. Recombinant analysis showed that the NFLG of GX2016EU09 composed of CRF01_AE (as the backbone) and CRF07_BC, with nine recombination break points observed in the gag, pol, vif, vpr, tat, rev, vpu, env, and nef regions. To our knowledge, this HIV-1 URF differs from previously documented CRF01_AE/CRF07_BC forms. The emergence of a novel CRF01_AE/CRF07_BC recombinant strain indicates the increasing complexity of the HIV-1 epidemic among the MSM group in Guangxi, China.

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DOI
10.1089/AID.2017.0101
pmid
28586246

Abstract

Currently, more and more kinds of circulating recombinant forms (CRFs) and unique recombinant forms (URFs) were identified in China. A novel second-generation CCR5-tropic HIV-1 recombinant virus (GX2016EU09) was identified here, which was isolated from a HIV-1-infected man who had sex with men (MSM) in Guangxi, China. Phylogenetic analysis of near full-length genome (NFLG) showed that the novel HIV-1 recombinant GX2016EU09 clustered with CRF01_AE reference sequences, but set up a distinct branch. Recombinant analysis showed that the NFLG of GX2016EU09 composed of CRF01_AE (as the backbone) and CRF07_BC, with nine recombination break points observed in the gag, pol, vif, vpr, tat, rev, vpu, env, and nef regions. To our knowledge, this HIV-1 URF differs from previously documented CRF01_AE/CRF07_BC forms. The emergence of a novel CRF01_AE/CRF07_BC recombinant strain indicates the increasing complexity of the HIV-1 epidemic among the MSM group in Guangxi, China.

Journal

AIDS research and human retrovirusesPubmed

Published: Jun 4, 2018

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