Get 20M+ Full-Text Papers For Less Than $1.50/day. Subscribe now for You or Your Team.

Learn More →

Elevation of substance P-like peptides in the CSF of psychiatric patients.

Elevation of substance P-like peptides in the CSF of psychiatric patients. Using a radioimmunoassay procedure substance P-like activity was measured in samples of human CSF obtained from 12 patients with major depressive disorder, 12 with schizophrenia, and 15 control cases diagnosed as psychiatrically normal. Levels were significantly higher in CSF of patients with depressive disorder as compared with schizophrenic patients or controls. Chemical characterization revealed that the measured activity was less basic than substance P itself and might be due to C-terminal fragments. A component reacting with an antiserum highly specific for the substance P[1-7]fragment was found in CSF of patients with depressive disorder. The results indicate that substance P-related peptides may be biological markers in psychoses, particularly in major depressive disorder. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biological psychiatry Pubmed

Elevation of substance P-like peptides in the CSF of psychiatric patients.

Biological psychiatry , Volume 19 (4): 8 – Aug 7, 1984

Elevation of substance P-like peptides in the CSF of psychiatric patients.


Abstract

Using a radioimmunoassay procedure substance P-like activity was measured in samples of human CSF obtained from 12 patients with major depressive disorder, 12 with schizophrenia, and 15 control cases diagnosed as psychiatrically normal. Levels were significantly higher in CSF of patients with depressive disorder as compared with schizophrenic patients or controls. Chemical characterization revealed that the measured activity was less basic than substance P itself and might be due to C-terminal fragments. A component reacting with an antiserum highly specific for the substance P[1-7]fragment was found in CSF of patients with depressive disorder. The results indicate that substance P-related peptides may be biological markers in psychoses, particularly in major depressive disorder.

Loading next page...
 
/lp/pubmed/elevation-of-substance-p-like-peptides-in-the-csf-of-psychiatric-RA0MEfL9SW

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

ISSN
0006-3223
pmid
6203562

Abstract

Using a radioimmunoassay procedure substance P-like activity was measured in samples of human CSF obtained from 12 patients with major depressive disorder, 12 with schizophrenia, and 15 control cases diagnosed as psychiatrically normal. Levels were significantly higher in CSF of patients with depressive disorder as compared with schizophrenic patients or controls. Chemical characterization revealed that the measured activity was less basic than substance P itself and might be due to C-terminal fragments. A component reacting with an antiserum highly specific for the substance P[1-7]fragment was found in CSF of patients with depressive disorder. The results indicate that substance P-related peptides may be biological markers in psychoses, particularly in major depressive disorder.

Journal

Biological psychiatryPubmed

Published: Aug 7, 1984

There are no references for this article.