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Temporal and spatial dynamics of cerebral immune cell accumulation in stroke.

Temporal and spatial dynamics of cerebral immune cell accumulation in stroke. Ischemic stroke leads to significant morbidity and mortality in the Western world. Early reperfusion strategies remain the treatment of choice but can initiate and augment an inflammatory response causing secondary brain damage. The understanding of postischemic inflammation is very limited. The objectives of this study were to define the temporal and spatial infiltration of immune cell populations and their activation patterns in a murine cerebral ischemia-reperfusion injury model. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Stroke Pubmed

Temporal and spatial dynamics of cerebral immune cell accumulation in stroke.

Temporal and spatial dynamics of cerebral immune cell accumulation in stroke.


Abstract

Ischemic stroke leads to significant morbidity and mortality in the Western world. Early reperfusion strategies remain the treatment of choice but can initiate and augment an inflammatory response causing secondary brain damage. The understanding of postischemic inflammation is very limited. The objectives of this study were to define the temporal and spatial infiltration of immune cell populations and their activation patterns in a murine cerebral ischemia-reperfusion injury model.

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ISSN
0039-2499
DOI
10.1161/STROKEAHA.108.534503
pmid
19265055
Publisher site
See Article on Publisher Site

Abstract

Ischemic stroke leads to significant morbidity and mortality in the Western world. Early reperfusion strategies remain the treatment of choice but can initiate and augment an inflammatory response causing secondary brain damage. The understanding of postischemic inflammation is very limited. The objectives of this study were to define the temporal and spatial infiltration of immune cell populations and their activation patterns in a murine cerebral ischemia-reperfusion injury model.

Journal

StrokePubmed

Published: May 14, 2009

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