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Testing models for genetic determination in migraine.

Testing models for genetic determination in migraine. We collected two clinically matched samples of patients, one sample affected by migraine with aura the other by migraine without aura, to investigate the genetic determination of these conditions. A maternal and X-linked transmission for both these diseases was considered unlikely after pedigree analysis. Classical segregation analysis indicated a likely autosomal recessive kind of transmission for both. Reduced penetrance and the h2 values, however, imply the presence of additional genetic and/or environmental factors controlling the phenotypic expression of migraine. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cephalalgia : an international journal of headache Pubmed

Testing models for genetic determination in migraine.

Cephalalgia : an international journal of headache , Volume 13 (6): 6 – Mar 23, 1994

Testing models for genetic determination in migraine.


Abstract

We collected two clinically matched samples of patients, one sample affected by migraine with aura the other by migraine without aura, to investigate the genetic determination of these conditions. A maternal and X-linked transmission for both these diseases was considered unlikely after pedigree analysis. Classical segregation analysis indicated a likely autosomal recessive kind of transmission for both. Reduced penetrance and the h2 values, however, imply the presence of additional genetic and/or environmental factors controlling the phenotypic expression of migraine.

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ISSN
0333-1024
DOI
10.1046/j.1468-2982.1993.1306389.x
pmid
8313452

Abstract

We collected two clinically matched samples of patients, one sample affected by migraine with aura the other by migraine without aura, to investigate the genetic determination of these conditions. A maternal and X-linked transmission for both these diseases was considered unlikely after pedigree analysis. Classical segregation analysis indicated a likely autosomal recessive kind of transmission for both. Reduced penetrance and the h2 values, however, imply the presence of additional genetic and/or environmental factors controlling the phenotypic expression of migraine.

Journal

Cephalalgia : an international journal of headachePubmed

Published: Mar 23, 1994

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