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The pharmacology of antidepressants at the synapse: focus on newer compounds.

The pharmacology of antidepressants at the synapse: focus on newer compounds. This paper reviews the in vitro effects of antidepressants on blockade of uptake of norepinephrine, serotonin, and dopamine at the synapse (rat synaptosomal preparations), as well as blockade of histamine H1, muscarinic, alpha 1-adrenergic, and dopamine D2 receptors in human brain tissue. The potency of an antidepressant at this blockade is predictive of the likelihood of its causing certain side effects and drug-drug interactions. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of clinical psychiatry Pubmed

The pharmacology of antidepressants at the synapse: focus on newer compounds.

The Journal of clinical psychiatry , Volume 55 Suppl A: 47003 – Nov 28, 1994

The pharmacology of antidepressants at the synapse: focus on newer compounds.


Abstract

This paper reviews the in vitro effects of antidepressants on blockade of uptake of norepinephrine, serotonin, and dopamine at the synapse (rat synaptosomal preparations), as well as blockade of histamine H1, muscarinic, alpha 1-adrenergic, and dopamine D2 receptors in human brain tissue. The potency of an antidepressant at this blockade is predictive of the likelihood of its causing certain side effects and drug-drug interactions.

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ISSN
0160-6689
pmid
7961541

Abstract

This paper reviews the in vitro effects of antidepressants on blockade of uptake of norepinephrine, serotonin, and dopamine at the synapse (rat synaptosomal preparations), as well as blockade of histamine H1, muscarinic, alpha 1-adrenergic, and dopamine D2 receptors in human brain tissue. The potency of an antidepressant at this blockade is predictive of the likelihood of its causing certain side effects and drug-drug interactions.

Journal

The Journal of clinical psychiatryPubmed

Published: Nov 28, 1994

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