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Y402H complement factor H polymorphism associated with exudative age-related macular degeneration in the French population.

Y402H complement factor H polymorphism associated with exudative age-related macular degeneration... Identification of genetic factors for age-related macular degeneration (AMD) is of crucial importance in this common cause of blindness. A positive association between Y402H polymorphism of the complement factor H (CFH) gene and AMD has been recently reported in North American populations but not yet in European populations. The exudative form of AMD is rapidly progressive and usually associated with a severe prognosis. Our purpose was to investigate this association in a French population specifically affected with exudative AMD, in a case-control study. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular vision Pubmed

Y402H complement factor H polymorphism associated with exudative age-related macular degeneration in the French population.

Y402H complement factor H polymorphism associated with exudative age-related macular degeneration in the French population.


Abstract

Identification of genetic factors for age-related macular degeneration (AMD) is of crucial importance in this common cause of blindness. A positive association between Y402H polymorphism of the complement factor H (CFH) gene and AMD has been recently reported in North American populations but not yet in European populations. The exudative form of AMD is rapidly progressive and usually associated with a severe prognosis. Our purpose was to investigate this association in a French population specifically affected with exudative AMD, in a case-control study.

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eISSN
1090-0535
pmid
16379025

Abstract

Identification of genetic factors for age-related macular degeneration (AMD) is of crucial importance in this common cause of blindness. A positive association between Y402H polymorphism of the complement factor H (CFH) gene and AMD has been recently reported in North American populations but not yet in European populations. The exudative form of AMD is rapidly progressive and usually associated with a severe prognosis. Our purpose was to investigate this association in a French population specifically affected with exudative AMD, in a case-control study.

Journal

Molecular visionPubmed

Published: Apr 13, 2006

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