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A streptavidin-functionalized tin disulfide nanoflake-based ultrasensitive electrochemical immunosensor for the detection of tumor markers

A streptavidin-functionalized tin disulfide nanoflake-based ultrasensitive electrochemical... In this research, we reported effective streptavidin-functionalized tin disulfide nanoflakes (SnS2 NFs) to develop an ultrasensitive electrochemical immunosensor for the bioanalysis of tumor markers. The streptavidin-functionalized SnS2 platform and immunosensor were characterized by scanning electron microscopy, electrochemical impedance spectroscopy, static water contact angle measurements and cyclic voltammetry. Biofunctionalized SnS2 NFs displayed a large specific surface area and outstanding hydrophilicity. These characteristics enhanced the loading efficiency and capacity of antibodies on the biosensing platform and ensured the biological activity of the immobilized protein biomolecules. Carcinoembryonic antigen (CEA) was chosen as the model analyte, and a wide linear range of 0.0063.0 ng mL1 with a low detection limit of 5 pg mL1 for CEA was exhibited by the immunosensor. Human serum sample analysis was achieved through the CEA immunosensor with satisfactory results. Streptavidin-functionalized SnS2 NFs offer a potential platform for the expansion of electrochemical immunosensor applications. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png NJC: New Journal of Chemistry Royal Society of Chemistry

A streptavidin-functionalized tin disulfide nanoflake-based ultrasensitive electrochemical immunosensor for the detection of tumor markers

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Publisher
Royal Society of Chemistry
Copyright
This journal is © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique
ISSN
1144-0546
eISSN
1369-9261
DOI
10.1039/d0nj00160k
Publisher site
See Article on Publisher Site

Abstract

In this research, we reported effective streptavidin-functionalized tin disulfide nanoflakes (SnS2 NFs) to develop an ultrasensitive electrochemical immunosensor for the bioanalysis of tumor markers. The streptavidin-functionalized SnS2 platform and immunosensor were characterized by scanning electron microscopy, electrochemical impedance spectroscopy, static water contact angle measurements and cyclic voltammetry. Biofunctionalized SnS2 NFs displayed a large specific surface area and outstanding hydrophilicity. These characteristics enhanced the loading efficiency and capacity of antibodies on the biosensing platform and ensured the biological activity of the immobilized protein biomolecules. Carcinoembryonic antigen (CEA) was chosen as the model analyte, and a wide linear range of 0.0063.0 ng mL1 with a low detection limit of 5 pg mL1 for CEA was exhibited by the immunosensor. Human serum sample analysis was achieved through the CEA immunosensor with satisfactory results. Streptavidin-functionalized SnS2 NFs offer a potential platform for the expansion of electrochemical immunosensor applications.

Journal

NJC: New Journal of ChemistryRoyal Society of Chemistry

Published: Apr 2, 2020

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