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Quantitative imaging of fluorine in human teeth by cryogenic laser ionization time-of-flight mass spectrometry

Quantitative imaging of fluorine in human teeth by cryogenic laser ionization time-of-flight mass... The scarcity of techniques for visualizing fluorine (F) hinders the comprehensive understanding of the role of anti-caries fluorides. This study introduced a liquid nitrogen cooling device into the laser ionization source to construct a novel cryogenic laser ionization time-of-flight mass spectrometry (Cryo-LI-TOFMS) imaging platform for F. The technique eliminated the interference of water-related species at m/z 19 and realized F imaging with a spatial resolution of 20 m. The quantitative imaging of 9 major elements in human teeth, including F, confirmed the feasibility of this method and revealed teeth compositions and mineralization environment. The quantitative imaging of F in teeth treated with different topical anti-caries drugs or different application times clarified the site and time of drug action, providing a solid foundation and promising prospects for drug research. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Analytical Atomic Spectroscopy Royal Society of Chemistry

Quantitative imaging of fluorine in human teeth by cryogenic laser ionization time-of-flight mass spectrometry

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Publisher
Royal Society of Chemistry
Copyright
This journal is © The Royal Society of Chemistry
ISSN
0267-9477
eISSN
1364-5544
DOI
10.1039/d2ja00338d
Publisher site
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Abstract

The scarcity of techniques for visualizing fluorine (F) hinders the comprehensive understanding of the role of anti-caries fluorides. This study introduced a liquid nitrogen cooling device into the laser ionization source to construct a novel cryogenic laser ionization time-of-flight mass spectrometry (Cryo-LI-TOFMS) imaging platform for F. The technique eliminated the interference of water-related species at m/z 19 and realized F imaging with a spatial resolution of 20 m. The quantitative imaging of 9 major elements in human teeth, including F, confirmed the feasibility of this method and revealed teeth compositions and mineralization environment. The quantitative imaging of F in teeth treated with different topical anti-caries drugs or different application times clarified the site and time of drug action, providing a solid foundation and promising prospects for drug research.

Journal

Journal of Analytical Atomic Spectroscopy – Royal Society of Chemistry

Published: Jan 30, 2023

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