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Effect of Barbiturates on Oxidative Phosphorylation.∗:

Effect of Barbiturates on Oxidative Phosphorylation.∗: Summary It has been shown that thiopental, pentobarbital and amobarbital lower the phosphate : oxygen uptake ratio obtained in particulate tissue preparations from liver and brain respiring on a pyruvate substrate. This depression is obtained at concentrations of the drugs which have only a slight effect on the oxygen uptake of the preparations and which approximate those which are necessary in vivo to produce surgical anesthesia. It is postulated that such an uncoupling of phosphorylation from oxidation may be one of the ways in which barbiturates act to produce anesthesia. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Proceedings of the Society for Experimental Biology and Medicine SAGE

Effect of Barbiturates on Oxidative Phosphorylation.∗:

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Publisher
SAGE
Copyright
Copyright © 2019 by The Society for Experimental Biology and Medicine
ISSN
0037-9727
eISSN
ISSN: 0037-9727
DOI
10.3181/00379727-77-18674
Publisher site
See Article on Publisher Site

Abstract

Summary It has been shown that thiopental, pentobarbital and amobarbital lower the phosphate : oxygen uptake ratio obtained in particulate tissue preparations from liver and brain respiring on a pyruvate substrate. This depression is obtained at concentrations of the drugs which have only a slight effect on the oxygen uptake of the preparations and which approximate those which are necessary in vivo to produce surgical anesthesia. It is postulated that such an uncoupling of phosphorylation from oxidation may be one of the ways in which barbiturates act to produce anesthesia.

Journal

Proceedings of the Society for Experimental Biology and MedicineSAGE

Published: Nov 8, 2016

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