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HIV-Associated Multicentric Castleman's Disease

HIV-Associated Multicentric Castleman's Disease Abstract Multicentric Castleman's disease (MCD) is a rare lymphoproliferative disorder. It is found with higher frequency in patients with HIV infection, with systemic symptoms and poor prognosis. We present the case of a 32-year old man with HIV disease, Kaposi's sarcoma, lymphadenopathy, fever and hemolytic anemia. A diagnosis of Castleman's disease is confirmed through biopsy and treatment is often based only on published case reports. Systemic treatments for MCD have included chemotherapy, anti-herpes virus, highly active antiretroviral therapy and, more recently, monoclonal antibodies against both IL6 and CD20. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Rare Tumors SAGE

HIV-Associated Multicentric Castleman's Disease

HIV-Associated Multicentric Castleman's Disease

Rare Tumors , Volume OnlineFirst: 1 – Aug 1, 2012

Abstract

Abstract Multicentric Castleman's disease (MCD) is a rare lymphoproliferative disorder. It is found with higher frequency in patients with HIV infection, with systemic symptoms and poor prognosis. We present the case of a 32-year old man with HIV disease, Kaposi's sarcoma, lymphadenopathy, fever and hemolytic anemia. A diagnosis of Castleman's disease is confirmed through biopsy and treatment is often based only on published case reports. Systemic treatments for MCD have included chemotherapy, anti-herpes virus, highly active antiretroviral therapy and, more recently, monoclonal antibodies against both IL6 and CD20.

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References (22)

Publisher
SAGE
Copyright
© 2012 SAGE Publications.
ISSN
2036-3613
eISSN
2036-3613
DOI
10.4081/rt.2012.e40
Publisher site
See Article on Publisher Site

Abstract

Abstract Multicentric Castleman's disease (MCD) is a rare lymphoproliferative disorder. It is found with higher frequency in patients with HIV infection, with systemic symptoms and poor prognosis. We present the case of a 32-year old man with HIV disease, Kaposi's sarcoma, lymphadenopathy, fever and hemolytic anemia. A diagnosis of Castleman's disease is confirmed through biopsy and treatment is often based only on published case reports. Systemic treatments for MCD have included chemotherapy, anti-herpes virus, highly active antiretroviral therapy and, more recently, monoclonal antibodies against both IL6 and CD20.

Journal

Rare TumorsSAGE

Published: Aug 1, 2012

Keywords: Castleman's disease; HIV; human herpes virus-8; Kaposi's sarcoma; rituximab

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