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A. Dirksen, S. Langereis, B. Waal, M. Genderen, E. Meijer, Q. Lussanet, T. Hackeng (2004)Design and synthesis of a bimodal target-specific contrast agent for angiogenesis.
Organic letters, 6 26
K. Sugahara, T. Teesalu, P. Karmali, V. Kotamraju, L. Agemy, O. Girard, D. Hanahan, R. Mattrey, E. Ruoslahti (2009)Tissue-penetrating delivery of compounds and nanoparticles into tumors.
Cancer cell, 16 6
Eliana Saxon, C. Bertozzi (2000)Cell surface engineering by a modified Staudinger reaction.
Science, 287 5460
Pamela Chang, Jennifer Prescher, Ellen Sletten, Jeremy Baskin, Isaac Miller, Nicholas Agard, Anderson Lo, C. Bertozzi (2010)Copper-free click chemistry in living animals
Proceedings of the National Academy of Sciences, 107
Juulia Enbäck, Pirjo Laakkonen (2007)Tumour-homing peptides: tools for targeting, imaging and destruction.
Biochemical Society transactions, 35 Pt 4
F. Rabanal, W. DeGrado, P. Dutton (1996)Use of 2,2′-dithiobis(5-nitropyridine) for the heterodimerization of cysteine containing peptides. Introduction of the 5-nitro-2-pyridinesulfenyl group
Tetrahedron Letters, 37
(1991)Cyclization of disulfidecontaining peptides in solid-phase synthesis
E. Ruoslahti, T. Duza, L. Zhang (2005)Vascular homing peptides with cell-penetrating properties.
Current pharmaceutical design, 11 28
E. Oliveira, J. Villén, E. Giralt, D. Andreu (2003)Synthetic approaches to multivalent lipopeptide dendrimers containing cyclic disulfide epitopes of foot-and-mouth disease virus.
Bioconjugate chemistry, 14 1
(2002)Regioselective bis - disulfide formation on solid support
Y. Ye, Lei Zhu, Ying Ma, G. Niu, Xiaoyuan Chen (2011)Synthesis and evaluation of new iRGD peptide analogs for tumor optical imaging.
Bioorganic & medicinal chemistry letters, 21 4
A. Act (2014)Breast Cancer: Basic and Clinical Research
L. Agemy, K. Sugahara, V. Kotamraju, Kunal Gujraty, O. Girard, Y. Kono, R. Mattrey, Ji-Ho Park, M. Sailor, A. Jiménez, C. Cativiela, D. Zanuy, Francisco Sayago, C. Alemán, R. Nussinov, E. Ruoslahti (2010)Nanoparticle-induced vascular blockade in human prostate cancer.
Blood, 116 15
Zhiguo Liu, Kaichun Wu (2008)Peptides homing to tumor vasculature: imaging and therapeutics for cancer.
Recent patents on anti-cancer drug discovery, 3 3
Ji-Ho Park, G. Maltzahn, Lianglin Zhang, A. Derfus, D. Simberg, T. Harris, E. Ruoslahti, S. Bhatia, M. Sailor (2009)Systematic surface engineering of magnetic nanoworms for in vivo tumor targeting.
Small, 5 6
Pirjo Laakkonen, K. Porkka, J. Hoffman, E. Ruoslahti (2002)A tumor-homing peptide with a targeting specificity related to lymphatic vessels
Nature Medicine, 8
G. Luo, Xianjun Yu, C. Jin, Feng Yang, D. Fu, J. Long, Jin Xu, Changyou Zhan, Weiyue Lu (2010)LyP-1-conjugated nanoparticles for targeting drug delivery to lymphatic metastatic tumors.
International journal of pharmaceutics, 385 1-2
C. Galmarini, G. Warren, M. Senanayake, S. Vinogradov (2010)Efficient overcoming of drug resistance to anticancer nucleoside analogs by nanodelivery of active phosphorylated drugs.
International journal of pharmaceutics, 395 1-2
C. Hackenberger, D. Schwarzer (2008)Chemoselective ligation and modification strategies for peptides and proteins.
Angewandte Chemie, 47 52
Xiang Li, Qiaofeng Jin, Tan Chen, Baoyue Zhang, R. Zheng, Zhanhui Wang, Hairong Zheng (2009)LyP-1 ultrasonic microbubbles targeting to cancer cell as tumor bio-acoustics markers or drug carriers: Targeting efficiency evaluation in, microfluidic channels
2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society
V. Fogal, Lianglin Zhang, S. Krajewski, E. Ruoslahti (2008)Mitochondrial/cell-surface protein p32/gC1qR as a molecular target in tumor cells and tumor stroma.
Cancer research, 68 17
David Peters, M. Kastantin, V. Kotamraju, P. Karmali, Kunal Gujraty, M. Tirrell, E. Ruoslahti (2009)Targeting atherosclerosis by using modular, multifunctional micelles
Proceedings of the National Academy of Sciences, 106
N. Beekman, W. Schaaper, G. Tesser, K. Dalsgaard, S. Kamstrup, J. Langeveld, R. Boshuizen, R. Meloen (2009)Synthetic peptide vaccines: palmitoylation of peptide antigens by a thioester bond increases immunogenicity.
The journal of peptide research : official journal of the American Peptide Society, 50 5
A. Galande, R. Weissleder, C. Tung (2005)An effective method of on-resin disulfide bond formation in peptides.
Journal of combinatorial chemistry, 7 2
Lise Feldborg, R. Jølck, T. Andresen (2012)Quantitative evaluation of bioorthogonal chemistries for surface functionalization of nanoparticles.
Bioconjugate chemistry, 23 12
Annie Tam, R. Raines (2009)Protein engineering with the traceless Staudinger ligation.
Methods in enzymology, 462
Miriam Góngora-Benítez, Judit Tulla-Puche, Marta Paradís-Bas, O. Werbitzky, M. Giraud, F. Albericio (2011)Optimized Fmoc solid‐phase synthesis of the cysteine‐rich peptide linaclotide
Peptide Science, 96
F. Albericio, R. Hammer, C. García-echeverría, M. Molins, J. Chang, M. Munson, M. Pons, E. Giralt, G. Barany (2009)Cyclization of disulfide-containing peptides in solid-phase synthesis.
International journal of peptide and protein research, 37 5
V. Mocharla, B. Colasson, Lac Lee, S. Roeper, K. Sharpless, Chi‐Huey Wong, H. Kolb (2004)In situ click chemistry: enzyme-generated inhibitors of carbonic anhydrase II.
Angewandte Chemie, 44 1
D. Simberg, T. Duza, J. Park, M. Essler, J. Pilch, Lianglin Zhang, A. Derfus, Meng Yang, R. Hoffman, S. Bhatia, M. Sailor, E. Ruoslahti (2007)Biomimetic amplification of nanoparticle homing to tumors
Proceedings of the National Academy of Sciences, 104
M. Akerman, W. Chan, Pirjo Laakkonen, S. Bhatia, E. Ruoslahti (2002)Nanocrystal targeting in vivo
Proceedings of the National Academy of Sciences of the United States of America, 99
D. Rijkers, R. Merkx, C. Yim, Arwin Brouwer, R. Liskamp (2010)‘Sulfo‐click’ for ligation as well as for site‐specific conjugation with peptides, fluorophores, and metal chelators
Journal of Peptide Science, 16
Shin-Hong Kang, Moo-Jung Cho, Ryszard Kole (1998)Up-regulation of luciferase gene expression with antisense oligonucleotides: implications and applications in functional assay development.
Biochemistry, 37 18
(2009)Recent advances in the use of cellpenetrating peptides for medical and biological applications
P. Karmali, V. Kotamraju, M. Kastantin, Matthew Black, D. Missirlis, M. Tirrell, E. Ruoslahti (2009)Targeting of albumin-embedded paclitaxel nanoparticles to tumors.
Nanomedicine : nanotechnology, biology, and medicine, 5 1
E. Ruoslahti, S. Bhatia, M. Sailor (2010)Targeting of drugs and nanoparticles to tumors
The Journal of Cell Biology, 188
Sonali Fonseca, Mark Pereira, S. Kelley (2009)Recent advances in the use of cell-penetrating peptides for medical and biological applications.
Advanced drug delivery reviews, 61 11
(2002)Regioselective bis-disulfide formation on solid support. Houben- Weyl: Methods in Organic Synthesis: Synthesis of Peptides and Peptidomimetics
E. Koivunen, D. Gay, E. Ruoslahti (1993)Selection of peptides binding to the alpha 5 beta 1 integrin from phage display library.
The Journal of biological chemistry, 268 27
Poornima Kolhar, V. Kotamraju, Sherry. Hikita, D. Clegg, E. Ruoslahti (2010)Synthetic surfaces for human embryonic stem cell culture.
Journal of biotechnology, 146 3
S. Maschauer, J. Einsiedel, R. Haubner, C. Hocke, M. Ocker, H. Hübner, T. Kuwert, P. Gmeiner, O. Prante (2010)Labeling and glycosylation of peptides using click chemistry: a general approach to (18)F-glycopeptides as effective imaging probes for positron emission tomography.
Angewandte Chemie, 49 5
Tumor-homing peptides with tissue-penetrating properties increase the efficacy of targeted cancer therapy by delivering an anticancer agent to the tumor interior. LyP-1 (CGNKRTRGC) and iRGD (CRGDKGPDC) are founding members of this class of peptides. The presence of the cysteines forming the cyclizing disulfide bond complicates conjugation of these peptides with other molecules, such as drugs. Here, we report the synthesis of conjugatable disulfide-bridged peptides and their conjugation to biologically important molecules. We have synthesized the LyP-1, iRGD, and CRGDC (GACRGDCLGA) peptides with a cysteine or maleimidohexanoic acid added externally at N-terminus of the sequences. Subsequent conjugation to payloads yielded stable compounds in which the tumor-homing properties of the peptide and the biological activity of the payload were retained.
Breast Cancer: Basic and Clinical Research – SAGE
Published: Jun 27, 2016
Keywords: tumor targeting; homing peptides; tumor-penetrating peptides; conjugatable disulfide peptides; cyclic peptide conjugation nanoworm conjugates; oligonucleotide conjugates
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