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Pluronic-phosphatidylcholine mixed polymeric nanomicellar formulation for curcumin drug bioavailability: Design, fabrication, characterization and in vitro bioinvestigations

Pluronic-phosphatidylcholine mixed polymeric nanomicellar formulation for curcumin drug... Curcumin (CUR), obtained from turmeric, has biological advantages, but low aqueous solubility restricts its pharmaceutical applications. In the present work, a mixed polymeric nanomicellar formulation composed of bioactive Pluronic P123, Pluronic F68, and biocompatible phosphatidylcholine (PC) was designed and examined as the nanovehicles for overcoming the major barriers of poor bioavailability related to CUR. The CUR-incorporated P123/F68/PC mixed nanomicellar formulation (CUR-PFPC) was fabricated by the thin film technique and investigated in vitro. The fabrication of CUR-PFPC was optimized through D-optimal design. CUR-PFPC morphology, size distribution, zeta potential, drug encapsulating and incorporation efficiency, compatibility, and crystallinity were characterized using DLS, TEM, FTIR, XRD, and DSC analysis. Moreover, the cumulative drug release, antioxidant assays, and antimicrobial properties of formulations were also examined. The CUR-PFPC formulation exhibited a micellar size of 67.43 nm, a zeta potential of −15.1 mV, a PDI of 0.528, and a spherical shape. The mixed micellar formulation showed excellent compatibility and stability. The in vitro release profile of the CUR-PFPC reached over 60% in comparison to the 95% release of CUR, indicating a slow and sustained release. The DPPH assay showed that the CUR-PFPC had 96% antioxidant activity. Results show that the CUR-PFPC has powerful antibacterial and antifungal properties, which separates it from the free CUR. These findings suggest that the fabricated CUR-PFPC mixed polymeric nanomicellar formulation is thermodynamically and kinetically stable and may be considered a novel nanovehicle for hydrophobic antimicrobial drugs like CUR.Graphical Abstract http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Bioactive and Compatible Polymers: Biomedical Applications SAGE

Pluronic-phosphatidylcholine mixed polymeric nanomicellar formulation for curcumin drug bioavailability: Design, fabrication, characterization and in vitro bioinvestigations

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Publisher
SAGE
Copyright
© The Author(s) 2023
ISSN
0883-9115
eISSN
1530-8030
DOI
10.1177/08839115231157098
Publisher site
See Article on Publisher Site

Abstract

Curcumin (CUR), obtained from turmeric, has biological advantages, but low aqueous solubility restricts its pharmaceutical applications. In the present work, a mixed polymeric nanomicellar formulation composed of bioactive Pluronic P123, Pluronic F68, and biocompatible phosphatidylcholine (PC) was designed and examined as the nanovehicles for overcoming the major barriers of poor bioavailability related to CUR. The CUR-incorporated P123/F68/PC mixed nanomicellar formulation (CUR-PFPC) was fabricated by the thin film technique and investigated in vitro. The fabrication of CUR-PFPC was optimized through D-optimal design. CUR-PFPC morphology, size distribution, zeta potential, drug encapsulating and incorporation efficiency, compatibility, and crystallinity were characterized using DLS, TEM, FTIR, XRD, and DSC analysis. Moreover, the cumulative drug release, antioxidant assays, and antimicrobial properties of formulations were also examined. The CUR-PFPC formulation exhibited a micellar size of 67.43 nm, a zeta potential of −15.1 mV, a PDI of 0.528, and a spherical shape. The mixed micellar formulation showed excellent compatibility and stability. The in vitro release profile of the CUR-PFPC reached over 60% in comparison to the 95% release of CUR, indicating a slow and sustained release. The DPPH assay showed that the CUR-PFPC had 96% antioxidant activity. Results show that the CUR-PFPC has powerful antibacterial and antifungal properties, which separates it from the free CUR. These findings suggest that the fabricated CUR-PFPC mixed polymeric nanomicellar formulation is thermodynamically and kinetically stable and may be considered a novel nanovehicle for hydrophobic antimicrobial drugs like CUR.Graphical Abstract

Journal

Journal of Bioactive and Compatible Polymers: Biomedical Applications – SAGE

Published: May 1, 2023

Keywords: Curcumin drug; mixed polymeric nanomicellar formulations; pluronic-phosphatidylcholine D-optimal design; antimicrobial activity

References

  • Curcumin: an age-old anti-inflammatory and anti-neoplastic agent
    Fadus, MC; Lau, C; Bikhchandani, J
  • A critical review of the properties and analytical methods for the determination of curcumin in biological and pharmaceutical matrices
    Carolina Alves, R; Perosa Fernandes, R; Fonseca-Santos, B
  • Curcumin production and bioavailability: a comprehensive review of curcumin extraction, synthesis, biotransformation and delivery systems
    Yixuan, L; Qaria, MA; Sivasamy, S
  • Therapeutic effect of curcumin in gastrointestinal cancers: a comprehensive review
    Morshedi, K; Borran, S; Ebrahimi, MS
  • Curcumin and curcumin-loaded nanoparticles: antipathogenic and antiparasitic activities
    Rai, M; Ingle, AP; Pandit, R
  • Curcumin-loaded poly-ε-caprolactone nanoparticles show antioxidant and cytoprotective effects in the presence of reactive oxygen species
    M Luisa, DPA; Griselda, RM; Valentín, ML
  • Bioavailability of curcumin: problems and promises
    Anand, P; Kunnumakkara, AB; Newman, RA
  • Highly bioavailable forms of curcumin and promising avenues for curcumin-based research and application: a review
    Stohs, SJ; Chen, O; Ray, SD
  • A short review on chemical properties, stability and nano-technological advances for curcumin delivery
    Slika, L; Patra, D
  • Polymeric micelles for oral drug delivery
    Gaucher, G; Satturwar, P; Jones, M-C
  • Multi-functional chitosan polymeric micelles as oral paclitaxel delivery systems for enhanced bioavailability and anti-tumor efficacy
    Chen, T; Tu, L; Wang, G
  • A fluorescence study of the loading and time stability of doxorubicin in sodium cholate/PEO-PPO-PEO triblock copolymer mixed micelles
    Tasca, E; Giudice, AD; Galantini, L
  • Novel soluplus(®)-TPGS mixed micelles for encapsulation of paclitaxel with enhanced in vitro cytotoxicity on breast and ovarian cancer cell lines
    Bernabeu, E; Gonzalez, L; Cagel, M
  • Targeting anticancer drugs with pluronic aggregates: recent updates
    Tiwari, S; Kansara, V; Bahadur, P
  • Brain targeting of olanzapine via intranasal delivery of core-shell difunctional block copolymer mixed nanomicellar carriers: in vitro characterization, ex vivo estimation of nasal toxicity and in vivo biodistribution studies
    Abdelbary, GA; Tadros, MI
  • Formulation, solubilization, and in vitro characterization of quercetin-incorporated mixed micelles of PEO-PPO-PEO block copolymers
    Patel, HS; Shaikh, SJ; Ray, D
  • Pluronic® block-copolymers in medicine: from chemical and biological versatility to rationalisation and clinical advances
    Pitto-Barry, A; Barry, NPE
  • Paclitaxel-loaded pluronic P123/F127 mixed polymeric micelles: formulation, optimization and in vitro characterization
    Wei, Z; Hao, J; Yuan, S
  • Binary mixed micellar systems of PEO-PPO-PEO block copolymers for lamotrigine solubilization: a comparative study with hydrophobic and hydrophilic copolymer
    Sharma, RK; Shaikh, S; Ray, D
  • Curcumin loaded mixed micelles composed of pluronic P123 and F68: preparation, optimization and in vitro characterization
    Zhao, L; Du, J; Duan, Y
  • Pullulan and pluronic F-127 based in situ gel system for intranasal delivery: development, in vitro and in vivo evaluation
    Mahajan, HS; Jadhao, VD; Chandankar, SM
  • Perspectives on: PEO-PPO-PEO triblock copolymers and their biomedical applications
    Fusco, S; Borzacchiello, A; Netti, PA
  • Novel self-assembled nano-tubular mixed micelles of pluronics P123, pluronic F127 and phosphatidylcholine for oral delivery of nimodipine: in vitro characterization, ex vivo transport and in vivo pharmacokinetic studies
    Basalious, EB; Shamma, RN
  • Micellar assisted aqueous stabilization of iron oxide nanoparticles for curcumin encapsulation and hyperthermia application
    Dutta, B; Rawoot, YA; Checker, S
  • Solubilization of poorly water-soluble drugs by mixed micelles based on hydrogenated phosphatidylcholine
    Rupp, C; Steckel, H; Müller, BW
  • Mixed micelle formation with phosphatidylcholines: the influence of surfactants with different molecule structures
    Rupp, C; Steckel, H; Müller, BW
  • Mixed micelles loaded with silybin-polyene phosphatidylcholine complex improve drug solubility
    Duan, RL; Sun, X; Liu, J
  • Development and optimization of baicalin-loaded solid lipid nanoparticles prepared by coacervation method using central composite design
    Hao, J; Wang, F; Wang, X
  • Zein/phospholipid composite nanoparticles for successful delivery of gallic acid into ahscs: influence of size, surface charge, and vitamin a coupling
    Radwan, SAA; El-Maadawy, WH; Yousry, C
  • Incorporation of lamotrigine drug in the PEO–PPO–PEO triblock copolymer (pluronic F127) micelles: effect of hydrophilic polymers
    Shaikh, S; Ray, D; Aswal, VK
  • In vitro antioxidant activity of extracts of Sybaris liquorice roots from Southern Italy
    Gabriele, B; Fazio, A; Carchedi, M
  • Antibacterial efficiency of Nelumbo nucifera (Nymphaeaceae) rhizomes extract
    Mukherjee, P; Balasubramanian, R; Saha, K
  • Designing of a thermosensitive chitosan/poloxamer in situ gel for ocular delivery of ciprofloxacin
    Varshosaz, J; Tabbakhian, M; Salmani, Z
  • Synthesis, characterization and antibacterial activity of a novel curcumin metal complex
    Bagchi, A; Mukherjee, P; Bhowmick, S
  • Quality by design: concept to applications
    Swain, S; Parhi, R; Jena, BR
  • Preparation, optimization, and evaluation of methoxy poly(ethylene glycol)-co-poly(ε-caprolactone) nanoparticles loaded by rivastigmine for brain delivery
    Mohamadpour, H; Azadi, A; Rostamizadeh, K
  • Phospholipid based colloidal poloxamer-nanocubic vesicles for brain targeting via the nasal route
    Salama, HA; Mahmoud, AA; Kamel, AO
  • Pluronic-based mixed polymeric micelles enhance the therapeutic potential of curcumin
    Akbar, MU; Zia, KM; Nazir, A
  • Core-shell biopolymer nanoparticle delivery systems: Synthesis and characterization of curcumin fortified zein-pectin nanoparticles
    Hu, K; Huang, X; Gao, Y
  • Curcumin-loaded mixed micelles: preparation, characterization, and in vitro antitumor activity
    Ji, S; Lin, X; Yu, E
  • Pluronic micelles encapsulated curcumin manifests apoptotic cell death and inhibits pro-inflammatory cytokines in human breast adenocarcinoma cells
    Vaidya, FU; Sharma, R; Shaikh, S
  • Evaluation and comparison of radical scavenging properties of solvent extracts from Justicia adhatoda leaf using DPPH assay
    Jha, DK; Panda, L; Ramaiah, S
  • Evaluation of antiviral activities of curcumin derivatives against HSV-1 in Vero cell line
    Zandi, K; Ramedani, E; Mohammadi, K
  • Enhanced anti-cancer and antimicrobial activities of curcumin nanoparticles
    Adahoun, MA; Al-Akhras, MH; Jaafar, MS
  • Curcumin nanoparticles: preparation, characterization, and antimicrobial study
    Bhawana Basniwal, RK; Buttar, HS
  • Optimized arylomycins are a new class of gram-negative antibiotics
    Smith, PA; Koehler, MFT; Girgis, HS
  • Turmeric powder (Curcuma longa linn.) as an antifungal agent in plant tissue culture studies
    Upendra, R; Pratima, K; Reddy, A