Access the full text.
Sign up today, get DeepDyve free for 14 days.
L. Sempere, J. Keto, M. Fabbri (2017)Exosomal MicroRNAs in Breast Cancer towards Diagnostic and Therapeutic Applications
L. Lima, A. Leal, Gabriele Vargas, I. Porto-Carreiro, R. Monteiro (2012)Intercellular transfer of tissue factor via the uptake of tumor-derived microvesicles.
Thrombosis research, 132 4
Anne-Kathleen Rupp, C. Rupp, Sascha Keller, J. Brase, R. Ehehalt, M. Fogel, G. Moldenhauer, F. Marmé, H. Sültmann, P. Altevogt (2011)Loss of EpCAM expression in breast cancer derived serum exosomes: role of proteolytic cleavage.
Gynecologic oncology, 122 2
A. Hendrix, D. Maynard, P. Pauwels, G. Braems, H. Denys, R. Broecke, J. Lambert, S. Belle, V. Cocquyt, C. Gespach, M. Bracke, M. Seabra, W. Gahl, O. Wever, W. Westbroek (2010)Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis.
Journal of the National Cancer Institute, 102 12
Ji-young Jang, Jongkuen Lee, Y. Jeon, C. Kim (2013)Exosome derived from epigallocatechin gallate treated breast cancer cells suppresses tumor growth by inhibiting tumor-associated macrophage infiltration and M2 polarization
BMC Cancer, 13
A. Bobrie, Marina Colombo, S. Krumeich, G. Raposo, C. Théry (2012)Diverse subpopulations of vesicles secreted by different intracellular mechanisms are present in exosome preparations obtained by differential ultracentrifugation
Journal of Extracellular Vesicles, 1
Lili Bao, S. Hazari, S. Mehra, D. Kaushal, K. Moroz, S. Dash (2012)Increased expression of P-glycoprotein and doxorubicin chemoresistance of metastatic breast cancer is regulated by miR-298.
The American journal of pathology, 180 6
G. Taraboletti, S. D'Ascenzo, I. Giusti, D. Marchetti, P. Borsotti, D. Millimaggi, R. Giavazzi, A. Pavan, V. Dolo (2006)Bioavailability of VEGF in tumor-shed vesicles depends on vesicle burst induced by acidic pH.
Neoplasia, 8 2
Xiuwei Yang, O. Kovalenko, Wei Tang, C. Claas, C. Stipp, M. Hemler (2004)Palmitoylation supports assembly and function of integrin–tetraspanin complexes
The Journal of Cell Biology, 167
H. Peinado, S. Lavotshkin, D. Lyden (2011)The secreted factors responsible for pre-metastatic niche formation: old sayings and new thoughts.
Seminars in cancer biology, 21 2
R. Rosell, Jia Wei, M. Taron (2009)Circulating MicroRNA Signatures of Tumor-Derived Exosomes for Early Diagnosis of Non-Small-Cell Lung Cancer.
Clinical lung cancer, 10 1
Liang Ma, Y. Li, Junya Peng, Danni Wu, Xiaoxin Zhao, Yitong Cui, Lilian Chen, Xiaojun Yan, Yanan Du, Li Yu (2014)Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration
Cell Research, 25
Jun-qing Chen, W. Tian, Hongke Cai, Hai-fei He, Yongchuan Deng (2012)Down-regulation of microRNA-200c is associated with drug resistance in human breast cancer
Medical Oncology, 29
E. Sierko, M. Wojtukiewicz (2007)Inhibition of platelet function: does it offer a chance of better cancer progression control?
Seminars in thrombosis and hemostasis, 33 7
N. Normanno, A. Luca, C. Bianco, L. Strizzi, M. Mancino, M. Maiello, A. Carotenuto, G. Feo, F. Caponigro, D. Salomon (2006)Epidermal growth factor receptor (EGFR) signaling in cancer.
Gene, 366 1
Q. Feng, Chengliang Zhang, D. Lum, J. Druso, Bryant Blank, K. Wilson, A. Welm, M. Antonyak, R. Cerione (2017)A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis
Nature Communications, 8
M. Fong, Weiying Zhou, Liang Liu, A. Alontaga, Manasa Chandra, Jonathan Ashby, A. Chow, Sean O’Connor, Shasha Li, Andrew Chin, G. Somlo, M. Palomares, Zhuo Li, Jacob Tremblay, Akihiro Tsuyada, Guoqiang Sun, M. Reid, Xiwei Wu, P. Swiderski, X. Ren, Yanhong Shi, Mei Kong, Wenwan Zhong, Yuan Chen, S. Wang (2015)Breast cancer-secreted miR-122 reprograms glucose metabolism in pre-metastatic niche to promote metastasis
Nature cell biology, 17
A. Clayton, Z. Tabi (2005)Exosomes and the MICA-NKG2D system in cancer.
Blood cells, molecules & diseases, 34 3
Yunlu Jia, Yongxia Chen, Qinchuan Wang, U. Jayasinghe, Xiao Luo, Qun Wei, Ji Wang, Hanchu Xiong, Cong Chen, Bin Xu, Wen-xian Hu, Linbo Wang, Wenhe Zhao, Jichun Zhou (2017)Exosome: emerging biomarker in breast cancer
Salma Khan, Heather Bennit, David Turay, Mia Perez, S. Mirshahidi, Yuan Yuan, N. Wall (2014)Early diagnostic value of survivin and its alternative splice variants in breast cancer
BMC Cancer, 14
S. Dutta, Case Warshall, Chirosree Bandyopadhyay, D. Dutta, B. Chandran (2014)Interactions between Exosomes from Breast Cancer Cells and Primary Mammary Epithelial Cells Leads to Generation of Reactive Oxygen Species Which Induce DNA Damage Response, Stabilization of p53 and Autophagy in Epithelial Cells
PLoS ONE, 9
Xianfeng Fang, P. Zheng, Jie Tang, Yang Liu (2010)CD24: from A to Z
Cellular and Molecular Immunology, 7
Hong Jiang, Zheng Li, Xiaohua Li, Jianguo Xia (2015)Intercellular transfer of messenger RNAs in multiorgan tumorigenesis by tumor cell-derived exosomes.
Molecular medicine reports, 11 6
Vicky Goler‐Baron, Irina Sladkevich, Y. Assaraf (2012)Inhibition of the PI3K-Akt signaling pathway disrupts ABCG2-rich extracellular vesicles and overcomes multidrug resistance in breast cancer cells.
Biochemical pharmacology, 83 10
Pyong‐Gon Moon, Jeongeun Lee, Young-Eun Cho, Soo Lee, J. Jung, Y. Chae, Han-Ik Bae, Young-Bum Kim, In‐San Kim, H. Park, M. Baek (2015)Identification of Developmental Endothelial Locus-1 on Circulating Extracellular Vesicles as a Novel Biomarker for Early Breast Cancer Detection
Clinical Cancer Research, 22
S. Melo, L. Luecke, C. Kahlert, A. Fernández, S. Gammon, Judith Kaye, Valerie LeBleu, E. Mittendorf, J. Weitz, N. Rahbari, C. Reissfelder, C. Pilarsky, M. Fraga, D. Piwnica-Worms, R. Kalluri (2015)Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
Yeping Dong, Qiongxi Pan, Li Jiang, Zhen Chen, Fangfang Zhang, Yanjun Liu, H. Xing, Mei Shi, Jiao Li, Xiyuan Li, Yaodan Zhu, Yun Chen, I. Bruce, Jian Jin, Xin Ma (2014)Tumor endothelial expression of P-glycoprotein upon microvesicular transfer of TrpC5 derived from adriamycin-resistant breast cancer cells.
Biochemical and biophysical research communications, 446 1
P. Kyrle, G. Hron, S. Eichinger, O. Wagner (2007)Circulating P-selectin and the risk of recurrent venous thromboembolism
Thrombosis and Haemostasis, 97
Octavio Galindo-Hernández, Nathalia Serna-Marquez, Rocío Castillo-Sánchez, E. Salazar (2014)Extracellular vesicles from MDA-MB-231 breast cancer cells stimulated with linoleic acid promote an EMT-like process in MCF10A cells.
Prostaglandins, leukotrienes, and essential fatty acids, 91 6
M. Mapara, M. Sykes (2004)Tolerance and cancer: mechanisms of tumor evasion and strategies for breaking tolerance.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 22 6
Shin-ichiro Ohno, M. Takanashi, K. Sudo, Shinobu Ueda, A. Ishikawa, N. Matsuyama, Koji Fujita, Takayuki Mizutani, T. Ohgi, T. Ochiya, N. Gotoh, M. Kuroda (2013)Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells.
Molecular therapy : the journal of the American Society of Gene Therapy, 21 1
K. O’Brien, S. Rani, C. Corcoran, R. Wallace, L. Hughes, A. Friel, S. Mcdonnell, J. Crown, M. Radomski, L. O’Driscoll (2013)Exosomes from triple-negative breast cancer cells can transfer phenotypic traits representing their cells of origin to secondary cells.
European journal of cancer, 49 8
Meng Lv, Xingya Zhu, Wei-xian Chen, Shanliang Zhong, Qing Hu, Teng-fei Ma, Jun Zhang, Lin Chen, Jin-hai Tang, Jian-hua Zhao (2014)Exosomes mediate drug resistance transfer in MCF-7 breast cancer cells and a probable mechanism is delivery of P-glycoprotein
Tumor Biology, 35
H. Peinado, M. Alečković, S. Lavotshkin, Irina Matei, B. Costa-Silva, G. Moreno-Bueno, M. Hergueta-Redondo, Caitlin Williams, G. García‐Santos, Cyrus Ghajar, Ayuko Nitadori-Hoshino, Caitlin Hoffman, K. Badal, B. Garcia, M. Callahan, Jianda Yuan, V. Martins, J. Skog, R. Kaplan, M. Brady, J. Wolchok, P. Chapman, Yibin Kang, J. Bromberg, D. Lyden (2012)Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
Nature Medicine, 18
G. Bendas, L. Borsig (2012)Cancer Cell Adhesion and Metastasis: Selectins, Integrins, and the Inhibitory Potential of Heparins
International Journal of Cell Biology, 2012
M. Bebawy, Valery Combes, Eun-Kyung Lee, Ritu Jaiswal, Joyce Gong, A. Bonhoure, Georges Grau (2009)Membrane microparticles mediate transfer of P-glycoprotein to drug sensitive cancer cells
E. Hay (2005)The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it
Developmental Dynamics, 233
Vicky Goler‐Baron, Y. Assaraf (2011)Structure and Function of ABCG2-Rich Extracellular Vesicles Mediating Multidrug Resistance
PLoS ONE, 6
M. Bebawy, M. Morris, B. Roufogalis (2001)Selective modulation of P-glycoprotein-mediated drug resistance
British Journal of Cancer, 85
Bethany Hannafon, Yvonne Trigoso, Cameron Calloway, Y. Zhao, D. Lum, A. Welm, Z. Zhao, K. Blick, W. Dooley, W. Ding (2016)Plasma exosome microRNAs are indicative of breast cancer
Breast Cancer Research : BCR, 18
Elisabeth Gustafson-Wagner, C. Stipp (2013)The CD9/CD81 Tetraspanin Complex and Tetraspanin CD151 Regulate α3β1 Integrin-Dependent Tumor Cell Behaviors by Overlapping but Distinct Mechanisms
PLoS ONE, 8
S. Ahmed, N. Das, Moumita Sarkar, U. Chatterjee, S. Chatterjee, M. Ghosh (2015)Exosome-mediated delivery of the intrinsic C-terminus domain of PTEN protects it from proteasomal degradation and ablates tumorigenesis.
Molecular therapy : the journal of the American Society of Gene Therapy, 23 2
S. Melo, H. Sugimoto, Joyce O’Connell, Noritoshi Kato, A. Villanueva, A. Vidal, Le Qiu, E. Vitkin, L. Perelman, C. Melo, A. Lucci, C. Ivan, G. Calin, R. Kalluri (2014)Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis.
Cancer cell, 26 5
Corinna Eichelser, Isabel Stückrath, V. Müller, K. Milde‐Langosch, H. Wikman, K. Pantel, H. Schwarzenbach (2014)Increased serum levels of circulating exosomal microRNA-373 in receptor-negative breast cancer patients
G. Hron, M. Kollars, H. Weber, V. Sagaster, P. Quehenberger, S. Eichinger, P. Kyrle, A. Weltermann (2006)Tissue factor-positive microparticles: Cellular origin and association with coagulation activation in patients with colorectal cancer
Thrombosis and Haemostasis, 97
Y. Song, Christine Warncke, S. Choi, Siyoung Choi, Aaron Chiou, L. Ling, Han Liu, S. Daniel, M. Antonyak, R. Cerione, C. Fischbach (2017)Breast cancer-derived extracellular vesicles stimulate myofibroblast differentiation and pro-angiogenic behavior of adipose stem cells.
Matrix biology : journal of the International Society for Matrix Biology, 60-61
J. Lu, Deep Pokharel, M. Bebawy (2015)MRP1 and its role in anticancer drug resistance
Drug Metabolism Reviews, 47
O. Kovalchuk, J. Filkowski, James Meservy, Y. Ilnytskyy, V. Tryndyak, V. Chekhun, I. Pogribny (2008)Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
Molecular Cancer Therapeutics, 7
D. Taylor, Ç. Gerçel-Taylor (2008)MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
Gynecologic oncology, 110 1
Weiying Zhou, M. Fong, Yongfen Min, G. Somlo, Liang Liu, M. Palomares, Yang Yu, A. Chow, Sean O’Connor, Andrew Chin, Y. Yen, Yafan Wang, E. Marcusson, P. Chu, Jun Wu, Xiwei Wu, A. Li, Zhuo Li, Hanlin Gao, X. Ren, M. Boldin, P. Lin, S. Wang (2014)UC Office of the President Recent Work Title Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis
Jaclyn Sceneay, M. Smyth, A. Möller (2013)The pre-metastatic niche: finding common ground
Cancer and Metastasis Reviews, 32
V. Luga, Liang Zhang, A. Viloria‐Petit, A. Ogunjimi, M. Inanlou, E. Chiu, M. Buchanan, A. Hosein, M. Basik, J. Wrana (2012)Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration
H. Hosseini, A. Fooladi, J. Soleimanirad, M. Nourani, S. Davaran, M. Mahdavi (2014)Staphylococcal entorotoxin B anchored exosome induces apoptosis in negative esterogen receptor breast cancer cells
Tumor Biology, 35
G. Nangami, Rainelli Koumangoye, J. Goodwin, A. Sakwe, Dana Marshall, J. Higginbotham, J. Ochieng (2014)Fetuin-A associates with histones intracellularly and shuttles them to exosomes to promote focal adhesion assembly resulting in rapid adhesion and spreading in breast carcinoma cells.
Experimental cell research, 328 2
J. Rak (2010)Microparticles in cancer.
Seminars in thrombosis and hemostasis, 36 8
H. Røberg-Larsen, Kaja Lund, Kristina Seterdal, Stian Solheim, T. Vehus, N. Solberg, S. Krauss, E. Lundanes, S. Wilson (2017)Mass spectrometric detection of 27-hydroxycholesterol in breast cancer exosomes
The Journal of Steroid Biochemistry and Molecular Biology, 169
S. Falati, Qingde Liu, P. Gross, Glenn Merrill-Skoloff, J. Chou, E. Vandendries, A. Celi, K. Croce, B. Furie, B. Furie (2003)Accumulation of Tissue Factor into Developing Thrombi In Vivo Is Dependent upon Microparticle P-Selectin Glycoprotein Ligand 1 and Platelet P-Selectin
The Journal of Experimental Medicine, 197
Ayuko Hoshino, B. Costa-Silva, Tang-Long Shen, G. Rodrigues, Ayako Hashimoto, M. Mark, H. Molina, S. Kohsaka, A. Giannatale, S. Ceder, Swarnima Singh, Caitlin Williams, Nadine Soplop, K. Uryu, Lindsay Pharmer, T. King, Linda Bojmar, A. Davies, Yonathan Ararso, Tuo Zhang, Haiying Zhang, Jonathan Hernandez, Joshua Weiss, Vanessa Dumont-Cole, K. Kramer, L. Wexler, A. Narendran, G. Schwartz, J. Healey, P. Sandstrom, K. Labori, E. Kure, P. Grandgenett, M. Hollingsworth, Maria Sousa, S. Kaur, Maneesh Jain, K. Mallya, S. Batra, W. Jarnagin, M. Brady, O. Fodstad, V. Muller, K. Pantel, A. Minn, M. Bissell, B. Garcia, Yibin Kang, Vinagolu Rajasekhar, Cyrus Ghajar, Irina Matei, H. Peinado, J. Bromberg, D. Lyden (2015)Tumour exosome integrins determine organotropic metastasis
B. Sung, T. Ketova, Daisuke Hoshino, A. Zijlstra, Alissa Weaver (2015)Directional cell movement through tissues is controlled by exosome secretion
Nature Communications, 6
S. Kruger, Z. Elmageed, D. Hawke, Philipp Wörner, D. Jansen, A. Abdel‐Mageed, E. Alt, R. Izadpanah (2014)Molecular characterization of exosome-like vesicles from breast cancer cells
BMC Cancer, 14
Javier Silva, V. García, Marta Rodríguez, M. Compte, E. Cisneros, P. Veguillas, J. García, G. Domínguez, Y. Campos-Martín, J. Cuevas, C. Peña, M. Herrera, Raquel Diaz, Nagat Mohammed, F. Bonilla (2012)Analysis of exosome release and its prognostic value in human colorectal cancer
Ting Wang, Daniele Gilkes, Naoharu Takano, Lisha Xiang, W. Luo, C. Bishop, P. Chaturvedi, J. Green, G. Semenza (2014)Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis
Proceedings of the National Academy of Sciences, 111
G. Palazzolo, N. Albanese, G. Cara, D. Gygax, M. Vittorelli, I. Pucci‐Minafra (2012)Proteomic analysis of exosome-like vesicles derived from breast cancer cells.
Anticancer research, 32 3
Marta Rodríguez, Javier Silva, Alberto Herrera, M. Herrera, C. Peña, Paloma Martin, B. Gil-Calderón, M. Larriba, M. Coronado, B. Soldevilla, V. Turrión, M. Provencio, Antonio Sánchez, F. Bonilla, V. García-Barberán (2015)Exosomes enriched in stemness/metastatic-related mRNAS promote oncogenic potential in breast cancer
R. Kaplan, R. Riba, S. Zacharoulis, Anna Bramley, L. Vincent, Carla Costa, Daniel MacDonald, D. Jin, K. Shido, Scott Kerns, Zhen-ping Zhu, D. Hicklin, Yan Wu, J. Port, N. Altorki, Elisa Port, D. Ruggero, S. Shmelkov, Kristian Jensen, S. Rafii, D. Lyden (2005)VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
Huang-Ge Zhang, Pengxiao Cao, Y. Teng, Xin Hu, Qi-long Wang, Ashish Yeri, Xiaoying Zhuang, A. Samykutty, J. Mu, Zhong‐bin Deng, Lifeng Zhang, J. Mobley, Jun Yan, K. Keuren-Jensen, Donald Miller (2016)Isolation, identification, and characterization of novel nanovesicles
Octavio Galindo-Hernández, Sócrates Villegas‐Comonfort, F. Candanedo, M. Gonzalez-Vazquez, S. Chávez-Ocaña, Xicoténcatl Jiménez-Villanueva, Mónica Sierra-Martínez, E. Salazar (2013)Elevated concentration of microvesicles isolated from peripheral blood in breast cancer patients.
Archives of medical research, 44 3
Jung-Ah Cho, Ho Park, Eun Lim, Kyo-Won Lee (2011)Exosomes from breast cancer cells can convert adipose tissue-derived mesenchymal stem cells into myofibroblast-like cells.
International journal of oncology, 40 1
M. Logozzi, A. Milito, L. Lugini, M. Borghi, L. Calabrò, M. Spada, M. Perdicchio, M. Marino, C. Federici, Elisabetta Iessi, D. Brambilla, G. Venturi, F. Lozupone, M. Santinami, V. Huber, M. Maio, L. Rivoltini, S. Fais (2009)High Levels of Exosomes Expressing CD63 and Caveolin-1 in Plasma of Melanoma Patients
PLoS ONE, 4
C. Théry, S. Amigorena, G. Raposo, A. Clayton (2006)Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids
Current Protocols in Cell Biology, 30
C-Y Wu, Shen-Lin Du, J. Zhang, A. Liang, Y. Liu (2016)Exosomes and breast cancer: a comprehensive review of novel therapeutic strategies from diagnosis to treatment
Cancer Gene Therapy, 24
K. O’Brien, Michelle Lowry, C. Corcoran, V. Martínez, Melissa Daly, S. Rani, W. Gallagher, M. Radomski, R. MacLeod, L. O’Driscoll (2015)miR-134 in extracellular vesicles reduces triple-negative breast cancer aggression and increases drug sensitivity
Ge Yang, Daoquan Wu, Jing Zhu, O. Jiang, Q. Shi, Jie Tian, Y. Weng (2013)Upregulation of miR-195 increases the sensitivity of breast cancer cells to Adriamycin treatment through inhibition of Raf-1.
Oncology reports, 30 2
Ruizhu Lin, Shihua Wang, R. Zhao (2013)Exosomes from human adipose-derived mesenchymal stem cells promote migration through Wnt signaling pathway in a breast cancer cell model
Molecular and Cellular Biochemistry, 383
M. Boelens, Tony Wu, B. Nabet, Bihui Xu, Yu Qiu, T. Yoon, Diana Azzam, Christina Victor, B. Wiemann, H. Ishwaran, P. Brugge, J. Jonkers, J. Slingerland, A. Minn (2014)Exosome Transfer from Stromal to Breast Cancer Cells Regulates Therapy Resistance Pathways
A. Chow, Weiying Zhou, Liang Liu, M. Fong, J. Champer, Desiree Haute, Andrew Chin, X. Ren, B. Gugiu, Z. Meng, Wendong Huang, V. Ngo, M. Kortylewski, S. Wang (2014)Macrophage immunomodulation by breast cancer-derived exosomes requires Toll-like receptor 2-mediated activation of NF-κB
Scientific Reports, 4
A. Suetsugu, Kimi Honma, S. Saji, H. Moriwaki, T. Ochiya, R. Hoffman (2013)Imaging exosome transfer from breast cancer cells to stroma at metastatic sites in orthotopic nude-mouse models.
Advanced drug delivery reviews, 65 3
Lili Bao, A. Haque, K. Jackson, S. Hazari, K. Moroz, R. Jetly, S. Dash (2011)Increased expression of P-glycoprotein is associated with doxorubicin chemoresistance in the metastatic 4T1 breast cancer model.
The American journal of pathology, 178 2
Shaohua Yu, Cunren Liu, K. Su, Jianhua Wang, Yuelong Liu, Liming Zhang, Chuanyu Li, Y. Cong, R. Kimberly, W. Grizzle, C. Falkson, Huang-Ge Zhang (2007)Tumor Exosomes Inhibit Differentiation of Bone Marrow Dendritic Cells1
The Journal of Immunology, 178
V. Golubovskaya (2014)Focal adhesion kinase and cross-linked signaling in cancer.
Anti-cancer agents in medicinal chemistry, 14 1
Jian-hua Shi, Yi Ren, Lin-Lin Zhen, Xiaolan Qiu (2015)Exosomes from breast cancer cells stimulate proliferation and inhibit apoptosis of CD133+ cancer cells in vitro.
Molecular medicine reports, 11 1
Cells can secrete extracellular vesicles (EVs) to communicate with neighboring or distant cells by EVs which are composed of a lipid bilayer containing transmembrane proteins and enclosing cytosolic proteins, lipids, and nucleic acids. Breast Cancer is the most frequently diagnosed malignancy with more than 1 million new cases each year and ranks the leading cause of cancer mortality in women worldwide. In this review, we will discuss recent progresses of the roles and mechanisms of cancer-derived EVs in metastatic breast cancer, with a special attention on tumor microenvironment construction, progression, and chemo/radiotherapy responses. This review also covers EV roles as biomarker and therapeutic target in clinical application.
Breast Cancer: Basic and Clinical Research – SAGE
Published: Apr 25, 2018
Keywords: Extracellular vesicles; breast cancer
Access the full text.
Sign up today, get DeepDyve free for 14 days.