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Sex differences in the course of autistic and co-occurring psychopathological symptoms in adolescents with and without autism spectrum disorder

Sex differences in the course of autistic and co-occurring psychopathological symptoms in... There is an ongoing debate as to whether autism spectrum disorder (ASD) is expressed differently in women than men. It is unclear whether differences found are specific to autism or merely reflecting normative development. In this study, we compared sex differences in developmental trajectories of autistic and co-occurring psychopathological symptoms in adolescents with milder forms of autism to those in a normative group matched for intelligence quotient (IQ) and socioeconomic status. Data of five assessment waves from ages 11 to 22 years were analyzed using linear mixed modeling. We found that in adolescence, sex differences in developmental trajectories of psychopathological symptoms specific for autism are confined to the repetitive stereotyped domain (males had higher scores on the sensory/stereotypic and resistance to change domains, the latter difference disappeared during adolescence due to an increase of these problems in females with ASD). Other sex differences, among which an increase over time in affective and anxiety problems in females was the most outstanding, were also observed in typically developing females. These sex-specific differences have relevance in the clinical care of men and women with autism, although they are subtle compared to differences between individuals with and without autism, which are broadly present in internalizing and externalizing problem domains.Lay abstractThere is an ongoing debate as to whether autism spectrum disorder (ASD) is expressed differently in women than men. Studies on sex differences in autistic symptoms and symptoms of other psychiatric problems present in individuals with autism generally do not include a general population comparison group, making it unclear whether differences are specific to autism or merely reflecting development in the general population. In this study, we compared sex differences in the course of autistic and at the same time present symptoms of other psychiatric problems in adolescents with milder forms of ASD to those in a group of the general population with an equal intelligence quotient (IQ) and socioeconomic status. Data of five assessment moments from ages 11 to 22 years were analyzed using a statistic procedure that allowed us to determine which factors affect the course of symptoms over time. We found that in adolescence, sex differences in the course of psychopathological symptoms specific for autism are confined to the repetitive stereotyped domains. Males had higher scores on the sensory/stereotypic and resistance to change domains, the latter difference disappeared during the course of adolescence due to an increase of these problems in autistic females. Other sex differences, among which an increase over time in mood and anxiety problems in females was the most outstanding, were also observed in females without autism. These sex-specific differences have relevance in the clinical care of autistic men and women, although they are subtle compared to differences between individuals with and without autism. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Autism: The International Journal of Research and Practice SAGE

Sex differences in the course of autistic and co-occurring psychopathological symptoms in adolescents with and without autism spectrum disorder

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Publisher
SAGE
Copyright
© The Author(s) 2023
ISSN
1362-3613
eISSN
1461-7005
DOI
10.1177/13623613221146477
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Abstract

There is an ongoing debate as to whether autism spectrum disorder (ASD) is expressed differently in women than men. It is unclear whether differences found are specific to autism or merely reflecting normative development. In this study, we compared sex differences in developmental trajectories of autistic and co-occurring psychopathological symptoms in adolescents with milder forms of autism to those in a normative group matched for intelligence quotient (IQ) and socioeconomic status. Data of five assessment waves from ages 11 to 22 years were analyzed using linear mixed modeling. We found that in adolescence, sex differences in developmental trajectories of psychopathological symptoms specific for autism are confined to the repetitive stereotyped domain (males had higher scores on the sensory/stereotypic and resistance to change domains, the latter difference disappeared during adolescence due to an increase of these problems in females with ASD). Other sex differences, among which an increase over time in affective and anxiety problems in females was the most outstanding, were also observed in typically developing females. These sex-specific differences have relevance in the clinical care of men and women with autism, although they are subtle compared to differences between individuals with and without autism, which are broadly present in internalizing and externalizing problem domains.Lay abstractThere is an ongoing debate as to whether autism spectrum disorder (ASD) is expressed differently in women than men. Studies on sex differences in autistic symptoms and symptoms of other psychiatric problems present in individuals with autism generally do not include a general population comparison group, making it unclear whether differences are specific to autism or merely reflecting development in the general population. In this study, we compared sex differences in the course of autistic and at the same time present symptoms of other psychiatric problems in adolescents with milder forms of ASD to those in a group of the general population with an equal intelligence quotient (IQ) and socioeconomic status. Data of five assessment moments from ages 11 to 22 years were analyzed using a statistic procedure that allowed us to determine which factors affect the course of symptoms over time. We found that in adolescence, sex differences in the course of psychopathological symptoms specific for autism are confined to the repetitive stereotyped domains. Males had higher scores on the sensory/stereotypic and resistance to change domains, the latter difference disappeared during the course of adolescence due to an increase of these problems in autistic females. Other sex differences, among which an increase over time in mood and anxiety problems in females was the most outstanding, were also observed in females without autism. These sex-specific differences have relevance in the clinical care of autistic men and women, although they are subtle compared to differences between individuals with and without autism.

Journal

Autism: The International Journal of Research and Practice – SAGE

Published: Jan 1, 2023

Keywords: adolescents; autism spectrum disorders; course; psychiatric comorbidity; sex differences

References

  • The experiences of late-diagnosed women with autism spectrum conditions: An investigation of the female autism phenotype
    Bargiela, S.; Steward, R.; Mandy, W.
  • Co-occurring trajectories of anxiety and insistence on sameness behaviour in autism spectrum disorder
    Baribeau, D. A.; Vigod, S.; Pullenayegum, E.; Kerns, C. M; Mirenda, P.; Smith, I. M.; Valliancourt, T.; Volden, J.; Waddell, C.; Zwaigenbaum, L.; Bennett, T.; Duku, E.; Elsabbagh, M.; Georgiades, S.; Ungar, W. J.; Zait, A. Z.; Szatmari, P.
  • Linking anxiety and insistence on sameness in autistic children: The role of sensory hypersensitivity
    Black, K. R.; Stevenson, R. A.; Segers, M.; Ncube, B. L.; Sun, S. Z.; Philipp-Muller, A.; Bebko, J. M.; Barense, M. D.; Ferber, S.
  • Developmental trajectories of externalizing behaviors in childhood and adolescence
    Bongers, I. L.; Koot, H. M.; van der Ende, J.; Verhulst, F. C.
  • Gender differences in mental disorders and suicidality in Europe: Results from a large cross-sectional population-based study
    Boyd, A.; Van de Velde, S.; Vilagut, G.; de Graaf; O’Neill, S.; Florescu, S.; Alonso, J.; Kovess-Masfety, V.
  • Autism spectrum disorder: An examination of sex differences in neuropsychological and self-report measures of executive and non-executive cognitive function
    Demetriou, E. A.; Pepper, K. L.; Park, S. H.; Pellicano, L.; Song, Y. J. C.; Naismith, S. L.; Hickie, I. B.; Thomas, E. E.; Guastella, A. J.
  • Developmental trajectories and predictors of externalizing behavior: A comparison of girls and boys
    Fernandez Castelao, C.; Kröner-Herwig, B
  • Camouflage and autism
    Fombonne, E.
  • Fixed effects, random effects and GEE: What are the differences?
    Gardiner, J. C.; Luo, Z.; Roman, L. A.
  • Depressive and anxiety symptom trajectories from school age through young adulthood in samples with autism spectrum disorder and developmental delay
    Gotham, K.; Brunwasser, S. M.; Lord, C.
  • Development of depression from preadolescence to young adulthood: Emerging gender differences in a 10-year longitudinal study
    Hankin, B. L.; Abramson, L. Y.; Moffitt, T. E.; Silva, P. A.; McGee, R.; Angell, K. E.
  • Depression from childhood into late adolescence: Influence of gender, development, genetic susceptibility, and peer stress
    Hankin, B. L.; Young, J. F.; Abela, J. R. Z.; Smolen, A.; Jenness, J. L.; Gulley, L. D.; Technow, J. R.; Gottieb, A. B.; Cohen, J. R.; Oppenheimer, C. W.
  • Changing ASD-ADHD symptom co-occurrence across the lifespan with adolescence as crucial time window: Illustrating the need to go beyond childhood
    Hartman, C. A.; Geurts, H. M.; Franke, B.; Buitelaar, J. K.; Rommelse, N. N. J.
  • Refinement of the Children’s Social Behavior Questionnaire (CSBQ): An instrument that describes the diverse problems seen in milder forms of PDD
    Hartman, C. A.; Luteijn, E.; Serra, M.; Minderaa, R.
  • Autism spectrum disorders: Sex differences in autistic behaviour domains and coexisting psychopathology
    Holtmann, M.; Bölte, S.; Poustka, F.
  • Adult manifestation of milder forms of autism spectrum disorder; autistic and non-autistic psychopathology
    Horwitz, E. H.; Schoevers, R. A.; Greaves-Lord, K.; de Bildt, A.; Hartman, C. A.
  • Gender ratios of administrative prevalence and incidence of attention-deficit/hyperactivity disorder (ADHD) across the lifespan: A nationwide population-based study in taiwan
    Huang, C. L.; Weng, S.; Ho, C.
  • Cohort profile: The Dutch “TRacking adolescents” individual lives’ survey’; TRAILS
    Huisman, M.; Oldehinkel, A. J.; de Winter, A.; Minderaa, R. B.; de Bildt, A.; Huizink, A. C.; Verhust, F. C.; Ormel, J.
  • The female autism phenotype and camouflaging: A narrative review
    Hull, L.; Petrides, K. V.; Mandy, W.
  • The relationship between intolerance of uncertainty and anxiety in autism: A systematic literature review and meta-analysis
    Jenkinson, R.; Milne, E.; Thompson, A.
  • Sex differences in scores on standardized measures of autism symptoms: A multisite integrative data analysis
    Kaat, A. J.; Shui, A. M.; Ghods, S. S.; Farmer, C. A.; Esler, A. N.; Thurm, A.; Georgiades, S.; Kanne, S. M.; Lord, C.; Kim, Y. S.; Bishop, S. L.
  • The development of aggression during adolescence: Sex differences in trajectories of physical and social aggression among youth in rural areas
    Karriker-Jaffe, K.; Foshee, V. A.; Ennett, S. T.; Suchindran, C.
  • The prevalence of anxiety and mood problems among children with autism and asperger syndrome
    Kim, J. A.; Szatmari, P.; Bryson, S. E.; Streiner, D. L.; Wilson, F. J.
  • ASD in females: Are we overstating the gender difference in diagnosis?
    Kreiser, N.; White, S.
  • Commentary: “camouflaging” in autistic people—reflection on fombonne (2020)
    Lai, M.; Hull, L.; Mandy, W.; Chakrabarti, B.; Nordahl, C. W.; Lombardo, M. V.; Amies, S. H.; Szatmari, P.; Baron-Cohen, S.; Happe, F.
  • Quantifying and exploring camouflaging in men and women with autism
    Lai, M.; Lombardo, M. V.; Ruigrok, A. N.; Chakrabarti, B.; Auyeung, B.; Szatmari, P.; Happe, F.; Baron-Cohen, S.
  • Gender differences in anxiety disorders and anxiety symptoms in adolescents
    Lewinsohn, P. M.; Gotlib, I. H.; Lewinsohn, M.; Seeley, J. R.; Allen, N. B.
  • Relations among restricted and repetitive behaviors, anxiety and sensory features in children with autism spectrum disorders
    Lidstone, J.; Uljarevic, M.; Sulliva, J.; Rodgers, J.; McConachie, H.; Freeston, M.; Le Couteur, A.; Prior, M.; Leekam, S.
  • What is the male-to-female ratio in autism spectrum disorder? A systematic review and meta-analysis
    Loomes, R.; Hull, L.; Mandy, W. P. L.
  • ASD symptom severity in adolescence of individuals diagnosed with PDD-NOS in childhood: Stability and the relation with psychiatric comorbidity and societal participation
    Louwerse, A.; Eussen, M. L. J. M.; Van, d. E.; de Nijs, P. F. A.; Van Gool, A. R.; Dekker, L. P.; Verheij, C.; Verheij, F.; Verhulst, F. C.; Greaves-Lord, K.
  • The children’s social behavior questionnaire for milder variants of PDD problems: Evaluation of the psychometric characteristics
    Luteijn, E.; Luteijn, F.; Jackson, S.; Volkmar, F.; Minderaa, R.
  • Utility of the CBCL DSM-oriented scales in assessing emotional disorders in youth with autism
    Magyar, C. I.; Pandolfi, V.
  • Meta-analysis of sex differences in social and communication function in children with autism spectrum disorder and attention-deficit/hyperactivity disorder
    Mahendiran, T.; Brian, J.; Dupuis, A.; Muhe, N.; Wong, P.; Iaboni, A.; Anagnostou, E.
  • A mixture-model approach to linking ADHD to adolescent onset of illicit drug use
    Malone, P. S.; Van Eck, K.; Flory, K.; Lamis, D. A.
  • Sex differences in autism spectrum disorder: Evidence from a large sample of children and adolescents
    Mandy, W.; Chilvers, R.; Chowdhury, U.; Salter, G.; Seigal, A.; Skuse, D.
  • The development of autistic social traits across childhood and adolescence in males and females
    Mandy, W.; Pellicano, L.; Pourcain, B.; Skuse, D.; Heron, J.
  • Sex differences in neurodevelopmental disorders
    May, T.; Adesina, I.; McGillivray, J.; Rinehart, N. J.
  • Sex differences in ADHD trajectories across childhood and adolescence
    Murray, A. L.; Booth, T.; Eisner, M.; Auyeung, B.; Murray, G.; Ribeaud, D.
  • Sex differences in externalizing and internalizing symptoms of children with ASD
    Nasca, B. C.; Lopata, C.; Donnelly, J. P.; Rodgers, J. D.; Thomeer, M. L.
  • Brain volumetric correlates of autism spectrum disorder symptoms in attention deficit/hyperactivity disorder
    O’Dwyer, L.; Tanner, C.; van Dongen, E. V.; Greven, C. U.; Bralten, J.; Zwiers, M. P.; Franke, B.; Oosterlaan, J.; Hesenfeld, D.; Hoekstra, P.; Hartman, C. A.; Rommelse, N.; Buitelaar, J. K.
  • Examining the intertwined development of prosocial skills and ASD symptoms in adolescence
    Oerlemans, A. M.; Rommelse, N. N. J.; Buitelaar, J. K.; Hartman, C. A.
  • Gender differences in anxiety trajectories from middle to late adolescence
    Ohannessian, C. M.; Milan, S.; Vannucci, A.
  • Cohort profile update: The TRacking adolescents’ individual lives survey (TRAILS)
    Oldehinkel, A. J.; Rosmalen, J. G.; Buitelaar, J. K.; Hoek, H. W.; Ormel, J.; Raven, D.; Reijneveld, V. A.; Veenstra, R.; Verhulst, F. C.; Vollebergh, W. M.; Hartman, C. A.
  • Sex differences in internalizing problems during adolescence in autism spectrum disorder
    Oswald, T. M.; Winter-Messiers, M.; Gibson, B.; Schmidt, A. M.; Herr, C. M.; Solomon, M.
  • An initial psychometric evaluation of the CBCL 6-18 in a sample of youth with autism spectrum disorders
    Pandolfi, V.; Magyar, C. I.; Dill, C. A.
  • The developmental progress in social behavior of children with autism spectrum disorder getting music therapy. A multiple case study
    Pater, M.; Spreen, M.; van Yperen, T.
  • Development of internalizing problems from adolescence to emerging adulthood: Accounting for heterotypic continuity with vertical scaling
    Petersen, I. T.; Lindhiem, O.; LeBeau, B.; Bates, J. E.; Pettit, G. S.; Lansford, J. E.; Dodge, K. A.
  • Behavioral and emotional problems in high-functioning girls and boys with autism spectrum disorders: Parents’ reports and adolescents’ self-reports
    Pisula, E.; Pudło, M.; Słowińska, M.; Kawa, R.; Strząska, M.; Banasiak, A.; Wolańczyk, T.
  • What about the girls? sex-based differences in autistic traits and adaptive skills
    Ratto, A. B.; Kenworthy, L.; Yerys, B. E.; Bascom, J.; Wieckowski, A. T.; White, S. W.; Wallace, G. L.; Pugliese, C.; Schultz, R. T.; Ollendick, T. H.; Scarpa, A.; Seese, S.; Register-Brown, K.; Martin, A.; Anthony, L. G.
  • Gender differences in core symptomatology in autism spectrum disorders across the lifespan
    Rivet, T.; Matson, J.
  • Stability of autistic traits in the general population: Further evidence for a continuum of impairment
    Robinson, E. B.; Munir, K.; Munafò, M. R.; Hughes, M.; McCormick, M. C.; Koenen, K. C.
  • Externalizing behavior from early childhood to adolescence: Prediction from inhibition, language, parenting, and attachment
    Roskam, I.
  • The contemporary face of gender differences and similarities in depression throughout adolescence: Development and chronicity
    Salk, R. H.; Petersen, J. L.; Abramson, L. Y.; Hyde, J. S.
  • Trajectories in symptoms of autism and cognitive ability in autism from childhood to adult life: Findings from a longitudinal epidemiological cohort
    Simonoff, E.; Kent, R.; Stringer, D.; Lord, C.; Briskman, J.; Lukito, S.; Pickles, A.; Charman, T.; Baird, G.
  • The developmental course of anxiety symptoms during adolescence: The TRAILS study
    Van Oort, F. V. A.; Greaves-Lord, K.; Verhulst, F. C.; Ormel, J.; Huizink, A. C
  • The stability of comorbid psychiatric disorders: A 7 year follow up of children with pervasive developmental disorder-not otherwise specified
    Verheij, C.; Louwerse, A.; Ende, J.; Eussen, M.; Gool, A.; Verheij, F.; Verhulst, F. C.; Greaves-Lord, K.
  • Sex differences in pervasive developmental disorders
    Volkmar, F. R.; Szatmari, P.
  • Characterizing the heterogeneous course of inattention and hyperactivity-impulsivity from childhood to young adulthood
    Vos, M.; Rommelse, N. N. J.; Franke, B.; Oosterlaan, J.; Heslenfeld, D. J.; Hoekstra, P. J.; Klein, H.; Faraone, S. V.; Buitlaar, J. K.; Hartman, C. A.
  • Analyzing longitudinal data with the linear mixed models procedure in SPSS
    West, B. T.
  • The interplay between sensory processing abnormalities, intolerance of uncertainty, anxiety and restricted and repetitive behaviours in autism spectrum disorder
    Wigham, S.; Rodgers, J.; South, M.; McConachie, H.; Freeston, M.
  • Research review: A systematic review and meta-analysis of sex/gender differences in social interaction and communication in autistic and nonautistic children and adolescents
    Wood-Downie, H.; Wong, B.; Kovshoff, H.; Cortese, S.; Hadwin, J. A.
  • Trajectories of internalizing and externalizing symptoms among adults with autism spectrum disorders
    Woodman, A. C.; Mailick, M. R.; Greenberg, J. S.