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Which Diagnostic Procedures in the Elderly? The Case of Late-Onset Huntington's Disease:

Which Diagnostic Procedures in the Elderly? The Case of Late-Onset Huntington's Disease: The typical adult-onset form of Huntington's disease (HD) is a clinical condition in which the latest advances of genetic research can be usefully applied during the course of the diagnostic process; not so clear are the guidelines for the much less frequent late-onset variant. We have recently seen three patients in their late sixties who had been misdiagnosed for up to 10 years due to the apparently isolated, mild, and slowly progressive nature of their hyperkinetic movements or cognitive disorders. Only after the results of DNA sequencing on a blood sample became available could the appropriate diagnosis of late-onset HD be reached. By contrast, neuroimaging studies lacked sufficient sensitivity and specificity. Appropriate neurogeriatric assessment in these cases should follow specific guidelines and should always include selected high-technology procedures. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Geriatric Psychiatry and Neurology SAGE

Which Diagnostic Procedures in the Elderly? The Case of Late-Onset Huntington's Disease:

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References (50)

Publisher
SAGE
Copyright
Copyright © 2019 by SAGE Publications
ISSN
0891-9887
eISSN
1552-5708
DOI
10.1177/089198879701000108
Publisher site
See Article on Publisher Site

Abstract

The typical adult-onset form of Huntington's disease (HD) is a clinical condition in which the latest advances of genetic research can be usefully applied during the course of the diagnostic process; not so clear are the guidelines for the much less frequent late-onset variant. We have recently seen three patients in their late sixties who had been misdiagnosed for up to 10 years due to the apparently isolated, mild, and slowly progressive nature of their hyperkinetic movements or cognitive disorders. Only after the results of DNA sequencing on a blood sample became available could the appropriate diagnosis of late-onset HD be reached. By contrast, neuroimaging studies lacked sufficient sensitivity and specificity. Appropriate neurogeriatric assessment in these cases should follow specific guidelines and should always include selected high-technology procedures.

Journal

Journal of Geriatric Psychiatry and NeurologySAGE

Published: Apr 1, 1997

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