Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

A CpG island methylator phenotype of colorectal cancer that is contiguous with conventional adenomas, but not serrated polyps

A CpG island methylator phenotype of colorectal cancer that is contiguous with conventional... A subset of colorectal cancers (CRCs) harbor the CpG island methylator phenotype (CIMP), with concurrent multiple promoter hypermethylation of tumor‑related genes. A serrated pathway in which CIMP is developed from serrated polyps is proposed. The present study characterized CIMP and morphologically examined precursor lesions of CIMP. In total, 104 CRCs treated between January 1996 and December 2004 were examined. Aberrant promoter methylation of 15 cancer‑related genes was analyzed. CIMP status was classified according to the number of methylated genes and was correlated with the clinicopathological features, including the concomitant polyps in and around the tumors. The frequency of aberrant methylation in each CRC showed a bimodal pattern, and the CRCs were classified as CIMP‑high (CIMP‑H), CIMP‑low (CIMP‑L) and CIMP‑negative (CIMP‑N). CIMP‑H was associated with aberrant methylation of MLH1 (P=0.005) and with an improved recurrence‑free survival (RFS) rate following curative resection compared with CIMP‑L/N (five‑year RFS rate, 93.8 vs. 67.1%; P=0.044), while CIMP‑N tumors were associated with frequent distant metastases at diagnosis (P=0.023). No concomitant serrated lesions were present in the tumors, whereas conventional adenoma was contiguous with 11 (10.6%) of 104 CRCs, including four CIMP‑H CRCs. CIMP‑H was classified in CRCs by a novel CIMP marker panel and the presence of concomitant tumors revealed that certain CIMP‑H CRCs may have arisen from conventional adenomas. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Oncology Letters Spandidos Publications

A CpG island methylator phenotype of colorectal cancer that is contiguous with conventional adenomas, but not serrated polyps

Download PDF
8 pages

Loading next page...
 
/lp/spandidos-publications/a-cpg-island-methylator-phenotype-of-colorectal-cancer-that-is-eIoxVCKzlJ

References (49)

Publisher
Spandidos Publications
Copyright
Copyright © Spandidos Publications
ISSN
1792-1074
eISSN
1792-1082
DOI
10.3892/ol.2014.2430
Publisher site
See Article on Publisher Site

Abstract

A subset of colorectal cancers (CRCs) harbor the CpG island methylator phenotype (CIMP), with concurrent multiple promoter hypermethylation of tumor‑related genes. A serrated pathway in which CIMP is developed from serrated polyps is proposed. The present study characterized CIMP and morphologically examined precursor lesions of CIMP. In total, 104 CRCs treated between January 1996 and December 2004 were examined. Aberrant promoter methylation of 15 cancer‑related genes was analyzed. CIMP status was classified according to the number of methylated genes and was correlated with the clinicopathological features, including the concomitant polyps in and around the tumors. The frequency of aberrant methylation in each CRC showed a bimodal pattern, and the CRCs were classified as CIMP‑high (CIMP‑H), CIMP‑low (CIMP‑L) and CIMP‑negative (CIMP‑N). CIMP‑H was associated with aberrant methylation of MLH1 (P=0.005) and with an improved recurrence‑free survival (RFS) rate following curative resection compared with CIMP‑L/N (five‑year RFS rate, 93.8 vs. 67.1%; P=0.044), while CIMP‑N tumors were associated with frequent distant metastases at diagnosis (P=0.023). No concomitant serrated lesions were present in the tumors, whereas conventional adenoma was contiguous with 11 (10.6%) of 104 CRCs, including four CIMP‑H CRCs. CIMP‑H was classified in CRCs by a novel CIMP marker panel and the presence of concomitant tumors revealed that certain CIMP‑H CRCs may have arisen from conventional adenomas.

Journal

Oncology Letters – Spandidos Publications

Published: Nov 1, 2014

There are no references for this article.