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H. Christofk, M. Heiden, M. Harris, A. Ramanathan, R. Gerszten, Ru Wei, M. Fleming, S. Schreiber, L. Cantley (2008)The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
Liju Wang, Qi Wang, Zhenshan Wang, Zhihong Yu, Jinguang Wang, Hai Xiong, Q. Yin, Yingyan Wang, Tao Wang, Shuping Tong (2006)[Relationship between chemosensitivity in vitro and the expression of GRP78 in non-small cell lung cancer].
Zhongguo fei ai za zhi = Chinese journal of lung cancer, 9 6
F. Yu, J. Megyesi, R. Safirstein, P. Price (2007)Involvement of the CDK2-E2F1 pathway in cisplatin cytotoxicity in vitro and in vivo.
American journal of physiology. Renal physiology, 293 1
J. Reedijk (2003)New clues for platinum antitumor chemistry: Kinetically controlled metal binding to DNA
Proceedings of the National Academy of Sciences of the United States of America, 100
Heng Ma, Kyla Jones, R. Guo, Peisheng Xu, Youqing Shen, Jun Ren (2010)Cisplatin compromises myocardial contractile function and mitochondrial ultrastructure: Role of endoplasmic reticulum stress
Clinical and Experimental Pharmacology and Physiology, 37
F. Yu, J. Megyesi, P. Price (2008)Cytoplasmic initiation of cisplatin cytotoxicity.
American journal of physiology. Renal physiology, 295 1
Amy Lee (2007)GRP78 induction in cancer: therapeutic and prognostic implications.
Cancer research, 67 8
K. Woźniak, J. Błasiak (2002)Recognition and repair of DNA-cisplatin adducts.
Acta biochimica Polonica, 49 3
C. Rabik, M. Fishel, J. Holleran, K. Kasza, M. Kelley, M. Egorin, M. Dolan (2008)Enhancement of Cisplatin [cis-Diammine Dichloroplatinum (II)] Cytotoxicity by O6-Benzylguanine Involves Endoplasmic Reticulum Stress
Journal of Pharmacology and Experimental Therapeutics, 327
M. Boyce, Junying Yuan (2006)Cellular response to endoplasmic reticulum stress: a matter of life or death
Cell Death and Differentiation, 13
T. Verfaillie, M. Salazar, G. Velasco, P. Agostinis (2010)Linking ER Stress to Autophagy: Potential Implications for Cancer Therapy
International Journal of Cell Biology, 2010
A. Ranganathan, Lin Zhang, A. Adam, J. Aguirre-Ghiso (2006)Functional coupling of p38-induced up-regulation of BiP and activation of RNA-dependent protein kinase-like endoplasmic reticulum kinase to drug resistance of dormant carcinoma cells.
Cancer research, 66 3
Zchong‐Zcho Wu, C. Chao (2010)Knockdown of NAPA using short-hairpin RNA sensitizes cancer cells to cisplatin: implications to overcome chemoresistance.
Biochemical pharmacology, 80 6
R. Feng, W. Zhai, H. Yang, Hui-fang Jin, Qin Zhang (2011)Induction of ER stress protects gastric cancer cells against apoptosis induced by cisplatin and doxorubicin through activation of p38 MAPK.
Biochemical and biophysical research communications, 406 2
S. Marciniak, D. Ron (2006)Endoplasmic reticulum stress signaling in disease.
Physiological reviews, 86 4
D. Coling, D. Ding, R. Young, M. Lis, Elizabeth Stofko, K. Blumenthal, R. Salvi (2007)Proteomic analysis of cisplatin-induced cochlear damage: Methods and early changes in protein expression
Hearing Research, 226
M. Peyrou, P. Hanna, A. Cribb (2007)Cisplatin, gentamicin, and p-aminophenol induce markers of endoplasmic reticulum stress in the rat kidneys.
Toxicological sciences : an official journal of the Society of Toxicology, 99 1
R. Chen, R. Dai, C. Duan, Y. Liu, S. Chen, D. Yan, C. Chen, M. Wei, H. Li (2011)Unfolded protein response suppresses cisplatin-induced apoptosis via autophagy regulation in human hepatocellular carcinoma cells.
Folia biologica, 57 3
A. Gorman, Sandra Healy, R. Jäger, Afshin Samali (2012)Stress management at the ER: regulators of ER stress-induced apoptosis.
Pharmacology & therapeutics, 134 3
Ye Xu, Hui-Xin Yu, Hanjiao Qin, Jinsong Kang, Chunyan Yu, Jiateng Zhong, Jing Su, Hongyan Li, Liankun Sun (2012)Inhibition of autophagy enhances cisplatin cytotoxicity through endoplasmic reticulum stress in human cervical cancer cells.
Cancer letters, 314 2
H. Heath-Engel, NC Chang, G. Shore (2008)The endoplasmic reticulum in apoptosis and autophagy: role of the BCL-2 protein family
F. Yu, J. Megyesi, R. Safirstein, P. Price (2007)Involvement of the CDK 2E 2 F 1 pathway in cisplatin cytotoxicity in vitro and in vivo
S. Oyadomari, S. Oyadomari, Masataka Mori (2004)Roles of CHOP/GADD153 in endoplasmic reticulum stress
Cell Death and Differentiation, 11
In-Ja Park, Min-Jung Kim, O. Park, W. Choe, I. Kang, Sung-soo Kim, J. Ha (2011)Cryptotanshinone induces ER stress-mediated apoptosis in HepG2 and MCF7 cells
A. Basu, Soumya Krishnamurthy (2010)Cellular Responses to Cisplatin-Induced DNA Damage
Journal of Nucleic Acids, 2010
Cheng-Tien Wu, M. Sheu, K. Tsai, C. Chiang, Shing-Hwa Liu (2011)Salubrinal, an eIF2α dephosphorylation inhibitor, enhances cisplatin-induced oxidative stress and nephrotoxicity in a mouse model.
Free radical biology & medicine, 51 3
Jianze Li, Amy Lee (2006)Stress induction of GRP78/BiP and its role in cancer.
Current molecular medicine, 6 1
Yidan Lin, Ziqiang Wang, Lunxu Liu, Longqi Chen (2011)Akt is the downstream target of GRP78 in mediating cisplatin resistance in ER stress-tolerant human lung cancer cells.
Lung cancer, 71 3
P. Pyrko, A. Schönthal, F. Hofman, Thomas Chen, Amy Lee (2007)The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas.
Cancer research, 67 20
Wang (2006)Relationship between chemosensitivity in vitro and the expression of GRP78 in non-small cell lung cancer
Chin J Lung Canc, 9
Gaddameedhi (2009)Association between the unfolded protein response, induced by 2-deoxyglucose, and hypersensitivity to cisplatin: a mechanistic study employing molecular genomics
J Cancer Res Ther Suppl, 1
M. Peyrou, A. Cribb (2007)Effect of endoplasmic reticulum stress preconditioning on cytotoxicity of clinically relevant nephrotoxins in renal cell lines.
Toxicology in vitro : an international journal published in association with BIBRA, 21 5
Deyang Kong, L. Zhuo, Changlu Gao, Suozhu Shi, Nan Wang, Zhiyong Huang, Wenge Li, Lirong Hao (2013)Erythropoietin protects against cisplatin-induced nephrotoxicity by attenuating endoplasmic reticulum stress-induced apoptosis.
Journal of nephrology, 26 1
A. Mandic, J. Hansson, S. Linder, M. Shoshan (2003)Cisplatin Induces Endoplasmic Reticulum Stress and Nucleus-independent Apoptotic Signaling*
The Journal of Biological Chemistry, 278
Francesca Rovetta, A. Stacchiotti, A. Consiglio, M. Cadei, P. Grigolato, A. Lavazza, R. Rezzani, M. Aleo (2012)ER signaling regulation drives the switch between autophagy and apoptosis in NRK-52E cells exposed to cisplatin.
Experimental cell research, 318 3
Huimei Yu, Jing Su, Ye Xu, Jinsong Kang, Hongyan Li, Ling Zhang, Hao-wei Yi, Xi-yan Xiang, Fei Liu, Liankun Sun (2011)p62/SQSTM1 involved in cisplatin resistance in human ovarian cancer cells by clearing ubiquitinated proteins.
European journal of cancer, 47 10
Jun Wu, R. Kaufman (2006)From acute ER stress to physiological roles of the Unfolded Protein Response
Cell Death and Differentiation, 13
S. Nawrocki, J. Carew, M. Pino, R. Highshaw, K. Dunner, Peng Huang, J. Abbruzzese, D. McConkey (2005)Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis.
Cancer research, 65 24
P. Loehrer, L. Einhorn (1984)Drugs five years later. Cisplatin.
Annals of internal medicine, 100 5
S. Gaddameedhi, S. Chatterjee (2009)Association between the unfolded protein response, induced by 2-deoxyglucose, and hypersensitivity to cisplatin: a mechanistic study employing molecular genomics.
Journal of cancer research and therapeutics, 5 Suppl 1
D. Rodriguez, D. Rojas-Rivera, C. Hetz (2011)Integrating stress signals at the endoplasmic reticulum: The BCL-2 protein family rheostat.
Biochimica et biophysica acta, 1813 4
Maiko Suzuki, Manabu Endo, F. Shinohara, S. Echigo, H. Rikiishi (2009)Enhancement of cisplatin cytotoxicity by SAHA involves endoplasmic reticulum stress-mediated apoptosis in oral squamous cell carcinoma cells
Cancer Chemotherapy and Pharmacology, 64
I. Martins, I. Martins, I. Martins, O. Kepp, O. Kepp, O. Kepp, F. Schlemmer, F. Schlemmer, F. Schlemmer, Sandy Adjemian, Sandy Adjemian, Sandy Adjemian, M. Tailler, M. Tailler, M. Tailler, Shensi Shen, Shensi Shen, Shensi Shen, M. Michaud, M. Michaud, M. Michaud, Laurie Menger, Laurie Menger, Laurie Menger, Abdelaziz Gdoura, Abdelaziz Gdoura, Abdelaziz Gdoura, N. Tajeddine, N. Tajeddine, N. Tajeddine, A. Tesnière, A. Tesnière, A. Tesnière, L. Zitvogel, L. Zitvogel, L. Zitvogel, G. Kroemer (2011)Restoration of the immunogenicity of cisplatin-induced cancer cell death by endoplasmic reticulum stress
Cisplatin (cis‑diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents and is widely used in the treatment of solid tumors. However, its side effects and acquired resistance gained during the course of treatment may limit its usage. It is generally considered to be a cytotoxic drug that kills cancer cells by damaging their DNA and inhibiting DNA synthesis to induce apoptosis via the mitochondrial death pathway or through plasma membrane disruption, triggering the Fas death receptor pathway. The endoplasmic reticulum (ER) is one of the most important protein‑folding compartments within the cell and an intracellular Ca2+ storage organelle. The ER contains a number of molecular chaperones, which may play an important role in determining cellular sensitivity to ER stress and apoptosis. The aim of this review was to summarize our current understanding regarding the mechanisms of ER stress response by which cisplatin induces cell death and the basis for cisplatin resistance. various aspects were addressed, including the two‑way regulation of ER stress, the involvement of ER stress in cisplatin‑induced cell death and drug resistance and the drugs enhancing cisplatin‑induced cell death by interfering with ER stress. An understanding of how ER stress signaling pathways regulate cisplatin‑induced cell death may enable the development of more effective therapeutic strategies for the treatment of cancer.
Molecular and Clinical Oncology – Spandidos Publications
Published: Jan 1, 2014
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