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Epstein‑Barr virus‑associated lymphoepithelial carcinoma arising in the parotid gland: A case report and literature review

Epstein‑Barr virus‑associated lymphoepithelial carcinoma arising in the parotid gland: A case... A 60‑year‑old woman presented with a 3‑year history of a slow‑growing, painless mass in their left parotid gland. Ultrasonography revealed a well‑circumscribed, lobulated, hypoechoic mass measuring 19x12x10 mm in the left parotid gland. Computed tomography revealed a well‑circumscribed, solid mass with homogeneous enhancement. Fluorodeoxyglucose‑positron emission tomography revealed uptake by the tumor but no uptake in other organs, including the nasopharynx. The patient underwent superficial parotidectomy with adequate safety margins and selective neck dissection followed by radiotherapy. No facial paralysis or recurrence of the tumor had been observed as of 20 months post‑operation. Histologically, the tumor was composed of sheets of syncytial cancer cells with prominent nucleoli in a dense lymphoplasmacytic background. Epstein‑Barr virus (EBV)‑encoded RNA in situ hybridization was diffusely positive in the tumor cells. These findings indicated that the tumor was an EBV‑associated lymphoepithelial carcinoma. Metastasis, especially from the nasopharynx, was excluded endoscopically and radiologically. Targeted next‑generation sequencing of 160 cancer‑related genes using the surgical specimen revealed no mutations, including known significant mutations detected in EBV‑associated nasopharyngeal carcinoma. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular and Clinical Oncology Spandidos Publications

Epstein‑Barr virus‑associated lymphoepithelial carcinoma arising in the parotid gland: A case report and literature review

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Publisher
Spandidos Publications
Copyright
Copyright \xC2\xA9 2023 Spandidos Publications
ISSN
2049-9450

Abstract

A 60‑year‑old woman presented with a 3‑year history of a slow‑growing, painless mass in their left parotid gland. Ultrasonography revealed a well‑circumscribed, lobulated, hypoechoic mass measuring 19x12x10 mm in the left parotid gland. Computed tomography revealed a well‑circumscribed, solid mass with homogeneous enhancement. Fluorodeoxyglucose‑positron emission tomography revealed uptake by the tumor but no uptake in other organs, including the nasopharynx. The patient underwent superficial parotidectomy with adequate safety margins and selective neck dissection followed by radiotherapy. No facial paralysis or recurrence of the tumor had been observed as of 20 months post‑operation. Histologically, the tumor was composed of sheets of syncytial cancer cells with prominent nucleoli in a dense lymphoplasmacytic background. Epstein‑Barr virus (EBV)‑encoded RNA in situ hybridization was diffusely positive in the tumor cells. These findings indicated that the tumor was an EBV‑associated lymphoepithelial carcinoma. Metastasis, especially from the nasopharynx, was excluded endoscopically and radiologically. Targeted next‑generation sequencing of 160 cancer‑related genes using the surgical specimen revealed no mutations, including known significant mutations detected in EBV‑associated nasopharyngeal carcinoma.

Journal

Molecular and Clinical Oncology – Spandidos Publications

Published: Mar 29, 2023

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