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- Publisher
- Spandidos Publications
- Copyright
- Copyright © Spandidos Publications
- ISSN
- 1792-1074
- eISSN
- 1792-1082
- DOI
- 10.3892/ol.2014.2463
- Publisher site
- See Article on Publisher Site
Abstract
The aim of the present study was to investigate the mechanism of SGC7901 cell resistance to cisplatin (CDDP). SGC7901/CDDP cells were established by the long‑term continuous exposure of SGC7901 cells to CDDP in stepwise concentration increments. The morphologies of the SGC7901/CDDP and SGC7901 cells were observed by microscopy. The expression levels of Survivin mRNA and protein in the SGC7901/CDDP and SGC7901 cells were examined by reverse transcription polymerase chain reaction and western blotting respectively. The results revealed morphological differences between the SGC7901 and SGC7901/CDDP cells. The expression levels of Survivin mRNA and protein were significantly higher in the SGC7901/CDDP cells than in the SGC7901 cells. Therefore, high expression levels of the Survivin gene may explain SGC7901 cell resistance to CDDP.
Journal
Oncology Letters – Spandidos Publications
Published: Nov 1, 2014