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Retrospective analysis of large‑scale research screening of construction workers for the early diagnosis of mesothelioma

Retrospective analysis of large‑scale research screening of construction workers for the early... The early diagnosis of mesothelioma, an aggressive malignant tumor, is considered to be important for prognosis. X‑ray is commonly used for the assessment of a mass in a population exhibiting a risk factor. However, there are currently no available studies indicating that such an assessment may be used to achieve early diagnosis and improve the patient's outcome. We previously reported that N‑ERC/mesothelin may be a useful blood tumor marker for mesothelioma. In order to investigate whether this tumor marker is useful for early diagnosis in a mass examination, in 2007 we initiated a 5‑year large‑scale screening of construction workers with a risk of asbestos exposure in Japan. Blood samples were collected annually and N‑ERC/mesothelin levels were determined. Based on the results of those findings, along with medical history and related data, we screened the participants to identify a high‑risk population. As a result, 62 subjects were identified among ~40,000 participants as the high‑risk population. Two of these 62 participants subsequently developed mesothelioma, although the remaining participants have not yet developed mesothelioma. In conclusion, N‑ERC/mesothelin may be useful as a blood tumor marker in the early diagnosis of mesothelioma in a mass examination. A future prospective study to confirm the findings of this research screening is currently under planning. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular and Clinical Oncology Spandidos Publications

Retrospective analysis of large‑scale research screening of construction workers for the early diagnosis of mesothelioma

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Publisher
Spandidos Publications
Copyright
Copyright © Spandidos Publications
ISSN
2049-9450
eISSN
2049-9469
DOI
10.3892/mco.2013.197
Publisher site
See Article on Publisher Site

Abstract

The early diagnosis of mesothelioma, an aggressive malignant tumor, is considered to be important for prognosis. X‑ray is commonly used for the assessment of a mass in a population exhibiting a risk factor. However, there are currently no available studies indicating that such an assessment may be used to achieve early diagnosis and improve the patient's outcome. We previously reported that N‑ERC/mesothelin may be a useful blood tumor marker for mesothelioma. In order to investigate whether this tumor marker is useful for early diagnosis in a mass examination, in 2007 we initiated a 5‑year large‑scale screening of construction workers with a risk of asbestos exposure in Japan. Blood samples were collected annually and N‑ERC/mesothelin levels were determined. Based on the results of those findings, along with medical history and related data, we screened the participants to identify a high‑risk population. As a result, 62 subjects were identified among ~40,000 participants as the high‑risk population. Two of these 62 participants subsequently developed mesothelioma, although the remaining participants have not yet developed mesothelioma. In conclusion, N‑ERC/mesothelin may be useful as a blood tumor marker in the early diagnosis of mesothelioma in a mass examination. A future prospective study to confirm the findings of this research screening is currently under planning.

Journal

Molecular and Clinical Oncology – Spandidos Publications

Published: Jan 1, 2014

References

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