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A Case-Based Guide to Clinical EndocrinologyAmiodarone-Induced Hyperthyroidism

A Case-Based Guide to Clinical Endocrinology: Amiodarone-Induced Hyperthyroidism Chapter 4 Paul Aoun and David S. Cooper Objectives Amiodarone is a potent antiarrhythmic drug that is associated with a wide array of adverse effects, including both hypothyroidism and hyperthyroidism. Here, we report the case of a 65-year-old man who was started on amiodarone for recurrent atrial fibrillation and 2 years later developed hyperthyroidism. We briefly review the normal changes in thyroid function tests that are seen with amiodarone. We then discuss the proposed etiologies, evaluation, and treatments of patients with amiodarone-induced thyrotoxicosis (AIT) type 1 and type 2. Case Presentation A.B. is a 65-year-old man with a past medical history of hypertension, atrial fib- rillation, and hyperlipidemia, but no history of thyroid disease. He was referred to the endocrine clinic for evaluation of probable amiodarone-induced hyperthy- roidism. Five years ago, the patient developed recurrent atrial fibrillation. After several failures of cardioversion, he was placed on amiodarone. Two years later, he noted weakness in his legs while walking or climbing stairs, and difficulty sleeping, hyperdefecation, and mild nervousness. He had no significant weight loss, palpita- tions, tremor, dysphagia, or neck pain. Prior to the initiation of amiodarone therapy and for almost the first 2 years of it, the patient http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

A Case-Based Guide to Clinical EndocrinologyAmiodarone-Induced Hyperthyroidism

Part of the Contemporary Endocrinology™ Book Series
Editors: Davies, Terry F.
Aoun, Paul; Cooper, David S.
Springer Journals — Jan 1, 2008
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Publisher
Humana Press
Copyright
© Humana Press,Totowa, NJ 2008
ISBN
978-1-58829-815-7
Pages
41 –48
DOI
10.1007/978-1-60327-103-5_4
Publisher site
See Chapter on Publisher Site

Abstract

Chapter 4 Paul Aoun and David S. Cooper Objectives Amiodarone is a potent antiarrhythmic drug that is associated with a wide array of adverse effects, including both hypothyroidism and hyperthyroidism. Here, we report the case of a 65-year-old man who was started on amiodarone for recurrent atrial fibrillation and 2 years later developed hyperthyroidism. We briefly review the normal changes in thyroid function tests that are seen with amiodarone. We then discuss the proposed etiologies, evaluation, and treatments of patients with amiodarone-induced thyrotoxicosis (AIT) type 1 and type 2. Case Presentation A.B. is a 65-year-old man with a past medical history of hypertension, atrial fib- rillation, and hyperlipidemia, but no history of thyroid disease. He was referred to the endocrine clinic for evaluation of probable amiodarone-induced hyperthy- roidism. Five years ago, the patient developed recurrent atrial fibrillation. After several failures of cardioversion, he was placed on amiodarone. Two years later, he noted weakness in his legs while walking or climbing stairs, and difficulty sleeping, hyperdefecation, and mild nervousness. He had no significant weight loss, palpita- tions, tremor, dysphagia, or neck pain. Prior to the initiation of amiodarone therapy and for almost the first 2 years of it, the patient

Published: Jan 1, 2008

Keywords: Thyroid Function Test; Multinodular Goiter; Antithyroid Drug; Amiodarone Therapy; Organic Iodine

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