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Chapter 20 Evaluation of Complex Primary Hyperparathyroidism Ee Lin Lim and Simon H.S. Pearce Case Presentation A 24-year-old woman was evaluated for persistent symptoms of stomach pain and vomiting following surgical treatment for hyperparathyroidism 2 years previously. She had undergone a neck exploration with excision of an enlarged left upper parathyroid gland; histology reported parathyroid hyperplasia. She was fatigued, had a poor appetite, and complained of intermittent constipation. She denied thirst or polyuria. She had a long history of mental illness, having been on lithium car- bonate treatment for more than 6 years. Her 52-year-old father was currently being evaluated for hypercalcemia at another center. She was also taking omeprazole 20 mg daily. Examination showed a thin but otherwise healthy young woman with a neck scar. Her laboratory data were as follows (with normal ranges): Serum calcium = 2.91 mmol/L (2.12–2.60) Serum albumin = 38 g/L (NR 34-50) Ionized calcium = 1.56 mmol/L (NR 1.19–1.37) Serum magnesium = 0.76 (NR 0.7–1.0) Serum creatinine = 78 mol/L (NR 70–140) Serum alkaline phosphatase = 128 U/L (NR 35–140) Urine calcium clearance to creatinine clearance ratio = 0.006 (on lithium) Urine calcium clearance to creatinine clearance ratio = 0.024 (7 days off
Published: Jan 1, 2008
Keywords: Parathyroid Gland; Primary Hyperparathyroidism; Lithium Treatment; Parathyroid Carcinoma; Urinary Calcium Excretion
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