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A Clinician's Pearls and Myths in RheumatologyGout Epidemiology

A Clinician's Pearls and Myths in Rheumatology: Gout Epidemiology [The prevalence of gout rises with advancing age. Among men and women older than 80 years of age, the prevalence of the disorder is 9% and 6%, respectively. Gout is more common among individuals with lower family income levels. This is probably attributable to a disproportionate occurrence within those income strata of other risk factors for gout, including hypertension, obesity, and dietary patterns. Ethanol or fructose consumption increases uric acid production by net adenosine triphosphate (ATP) degradation to adenosine monophosphate (AMP). AMP is degraded rapidly to uric acid. Two major genetic mutations lead to gout, urolithiasis, and related problems: Mutations in the gene that encodes hypoxanthine-guanine phosphoribosyl transferase are associated with a spectrum of diseases in children, which ranges from the Lesch—Nyhan syndrome at the severe end of the spectrum to simple hyperuricemia at the mild end. Mutations in the 5'-phosphoribosyl-1-pyrophosphate (PRPP) synthetase genes can result in overactivity of the pathway, leading ultimately to increased urate production.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

A Clinician's Pearls and Myths in RheumatologyGout Epidemiology

Editors: Stone, John H.
Choi, Hyon K.
A Clinician's Pearls and Myths in Rheumatology — Jan 1, 2009
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Publisher
Springer London
Copyright
© Springer-Verlag London 2009
ISBN
978-1-84800-933-2
Pages
355 –359
DOI
10.1007/978-1-84800-934-9_35
Publisher site
See Chapter on Publisher Site

Abstract

[The prevalence of gout rises with advancing age. Among men and women older than 80 years of age, the prevalence of the disorder is 9% and 6%, respectively. Gout is more common among individuals with lower family income levels. This is probably attributable to a disproportionate occurrence within those income strata of other risk factors for gout, including hypertension, obesity, and dietary patterns. Ethanol or fructose consumption increases uric acid production by net adenosine triphosphate (ATP) degradation to adenosine monophosphate (AMP). AMP is degraded rapidly to uric acid. Two major genetic mutations lead to gout, urolithiasis, and related problems: Mutations in the gene that encodes hypoxanthine-guanine phosphoribosyl transferase are associated with a spectrum of diseases in children, which ranges from the Lesch—Nyhan syndrome at the severe end of the spectrum to simple hyperuricemia at the mild end. Mutations in the 5'-phosphoribosyl-1-pyrophosphate (PRPP) synthetase genes can result in overactivity of the pathway, leading ultimately to increased urate production.]

Published: Jan 1, 2009

Keywords: Uric Acid; Serum Uric Acid; Serum Uric Acid Level; Dairy Consumption; Serum Uric Acid Concentration

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