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A Clinician's Pearls and Myths in RheumatologySjögren's Syndrome

A Clinician's Pearls and Myths in Rheumatology: Sjögren's Syndrome [Primary Sjögren's syndrome (SjS) is a systemic autoimmune disease that is associated with early and gradually progressive lacrimal and salivary dysfunction. Secondary SjS occurs in association with other autoimmune disorders, the most common of which is rheumatoid arthritis. About 90% of patients with SjS are women. Minor salivary glands and lacrimal glands in SjS exhibit a particular pattern of periductal focal lymphocytic infiltration known as focal lymphocytic sialadenitis. Primary SjS has a community prevalence that ranges from 0.1 to 0.6%. The major eye problem in SjS is keratoconjunctivitis sicca, which leads to xerophthalmia. The principal oral manifestation of SjS is decreased salivary gland production, leading to xerostomia and a predilection for dental caries. Extraglandular manifestations of SjS include arthral-gias, thyroiditis, renal involvement (leading to renal tubular acidosis (RTA)), peripheral neuropathy, cutaneous vasculitis, and lymphoma. The risk of lymphoma in SjS is approximately 5%. Most patients with SjS develop increased circulating polyclonal immunoglobulins and autoantibodies. These autoantibodies include two fairly specific antibodies directed against the Ro (SS-A) and La (SS-B) antigens.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

A Clinician's Pearls and Myths in RheumatologySjögren's Syndrome

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Publisher
Springer London
Copyright
© Springer-Verlag London 2009
ISBN
978-1-84800-933-2
Pages
107 –130
DOI
10.1007/978-1-84800-934-9_12
Publisher site
See Chapter on Publisher Site

Abstract

[Primary Sjögren's syndrome (SjS) is a systemic autoimmune disease that is associated with early and gradually progressive lacrimal and salivary dysfunction. Secondary SjS occurs in association with other autoimmune disorders, the most common of which is rheumatoid arthritis. About 90% of patients with SjS are women. Minor salivary glands and lacrimal glands in SjS exhibit a particular pattern of periductal focal lymphocytic infiltration known as focal lymphocytic sialadenitis. Primary SjS has a community prevalence that ranges from 0.1 to 0.6%. The major eye problem in SjS is keratoconjunctivitis sicca, which leads to xerophthalmia. The principal oral manifestation of SjS is decreased salivary gland production, leading to xerostomia and a predilection for dental caries. Extraglandular manifestations of SjS include arthral-gias, thyroiditis, renal involvement (leading to renal tubular acidosis (RTA)), peripheral neuropathy, cutaneous vasculitis, and lymphoma. The risk of lymphoma in SjS is approximately 5%. Most patients with SjS develop increased circulating polyclonal immunoglobulins and autoantibodies. These autoantibodies include two fairly specific antibodies directed against the Ro (SS-A) and La (SS-B) antigens.]

Published: Jan 1, 2009

Keywords: Salivary Gland; Mixed Cryoglobulinemia; Burning Mouth Syndrome; Keratoconjunctivitis Sicca; Gland Enlargement

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