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A Framework for Quantifying Qualitative Responses in Pairwise Experiments

A Framework for Quantifying Qualitative Responses in Pairwise Experiments Suppose an experiment is conducted on pairs of objects with outcome response a continuous variable measuring the interactions among the pairs. Furthermore, assume the response variable is hard to measure numerically but we may code its values into low and high levels of interaction (and possibly a third category in between if neither label applies). In this paper, we estimate the interaction values from the information contained in the coded data and the design structure of the experiment. A novel estimation method is introduced and shown to enjoy several optimal properties including maximum explained variance in the responses with minimum number of parameters and for any probability distribution underlying the responses. Furthermore, the interactions have the simple interpretation of correlation (in absolute value), size of error is estimable from the experiment, and only a single run of each pair is needed for the experiment. We also explore possible applications of the technique. Three applications are presented, one on protein interaction, a second on drug combination, and the third on machine learning. The first two applications are illustrated using real life data while for the third application, the data are generated via binary coding of an image. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Classification Springer Journals

A Framework for Quantifying Qualitative Responses in Pairwise Experiments

Al-Ibrahim, A. H.
Journal of Classification , Volume 36 (3) – Oct 22, 2019
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References (25)

Publisher
Springer Journals
Copyright
Copyright © The Classification Society 2019. corrected publication 2019
Subject
Statistics; Statistical Theory and Methods; Pattern Recognition; Bioinformatics; Signal,Image and Speech Processing; Psychometrics; Marketing
ISSN
0176-4268
eISSN
1432-1343
DOI
10.1007/s00357-019-09337-1
Publisher site
See Article on Publisher Site

Abstract

Suppose an experiment is conducted on pairs of objects with outcome response a continuous variable measuring the interactions among the pairs. Furthermore, assume the response variable is hard to measure numerically but we may code its values into low and high levels of interaction (and possibly a third category in between if neither label applies). In this paper, we estimate the interaction values from the information contained in the coded data and the design structure of the experiment. A novel estimation method is introduced and shown to enjoy several optimal properties including maximum explained variance in the responses with minimum number of parameters and for any probability distribution underlying the responses. Furthermore, the interactions have the simple interpretation of correlation (in absolute value), size of error is estimable from the experiment, and only a single run of each pair is needed for the experiment. We also explore possible applications of the technique. Three applications are presented, one on protein interaction, a second on drug combination, and the third on machine learning. The first two applications are illustrated using real life data while for the third application, the data are generated via binary coding of an image.

Journal

Journal of Classification – Springer Journals

Published: Oct 22, 2019

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