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A locus for bipolar affective disorder on chromosome 4p

A locus for bipolar affective disorder on chromosome 4p The main clinical feature of bipolar affective disorder is a change of mood to depression or elation. Unipolar disorder, also termed majc depressive disorder, describes the occurrence c depression alone without episodes of elevate mood. Little is understood about the underlyim, causes of these common and severe illnesse which have estimated lifetime prevalences in th region of 0.8% for bipolar and 6% for unipola disorder1. Strong support for a genetic aetiolog is found in the familial nature of the condition, th increased concordance of monozygotic ove dizygotic twins2 and adoption studies showing increased rates of illness in children of affecte parents3. However, linkage studies have met wit mixed success. An initial report of linkage on th short arm of chromosome 11 (ref. 4) was revised5 and remains unreplicated. Reports proposirr cosegregation of genes found on the X chromosome with bipolar illness6 have not been supported by others7. More recently bipolar disorder ha been reported to be linked with markers on chromosomes 18, 21, 16 and a region on the X chromosome8–10 different from those previousl suggested11. We have carried out a linkage stud in twelve bipolar families. In a single family genome search employing 193 markers indicate linkage on chromosome 4p where the marke D4S394 generated a two-point lod score of 4. under a dominant model of inheritance. Thre point analyses with neighbouring markers gave maximum lod score of 4.8. Eleven other bipols families were typed using D4S394 and in all fam lies combined there was evidence of linkage wit heterogeneity with a maximum two-point lo score of 4.1 (θ = 0, α = 0.35). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Genetics Springer Journals

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References (39)

Publisher
Springer Journals
Copyright
Copyright © 1996 by Nature Publishing Group
Subject
Biomedicine; Biomedicine, general; Human Genetics; Cancer Research; Agriculture; Gene Function; Animal Genetics and Genomics
ISSN
1061-4036
eISSN
1546-1718
DOI
10.1038/ng0496-427
Publisher site
See Article on Publisher Site

Abstract

The main clinical feature of bipolar affective disorder is a change of mood to depression or elation. Unipolar disorder, also termed majc depressive disorder, describes the occurrence c depression alone without episodes of elevate mood. Little is understood about the underlyim, causes of these common and severe illnesse which have estimated lifetime prevalences in th region of 0.8% for bipolar and 6% for unipola disorder1. Strong support for a genetic aetiolog is found in the familial nature of the condition, th increased concordance of monozygotic ove dizygotic twins2 and adoption studies showing increased rates of illness in children of affecte parents3. However, linkage studies have met wit mixed success. An initial report of linkage on th short arm of chromosome 11 (ref. 4) was revised5 and remains unreplicated. Reports proposirr cosegregation of genes found on the X chromosome with bipolar illness6 have not been supported by others7. More recently bipolar disorder ha been reported to be linked with markers on chromosomes 18, 21, 16 and a region on the X chromosome8–10 different from those previousl suggested11. We have carried out a linkage stud in twelve bipolar families. In a single family genome search employing 193 markers indicate linkage on chromosome 4p where the marke D4S394 generated a two-point lod score of 4. under a dominant model of inheritance. Thre point analyses with neighbouring markers gave maximum lod score of 4.8. Eleven other bipols families were typed using D4S394 and in all fam lies combined there was evidence of linkage wit heterogeneity with a maximum two-point lo score of 4.1 (θ = 0, α = 0.35).

Journal

Nature GeneticsSpringer Journals

Published: Apr 1, 1996

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