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A MYC–aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer

A MYC–aurora kinase A protein complex represents an actionable drug target in p53-altered liver... In Trp53-mutated hepatocellular carcinoma, conformation-changing aurora kinase A inhibitors disrupt aurora kinase A–MYC interactions, resulting in MYC degradation and suppression of tumor growth. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Medicine Springer Journals

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References (63)

Publisher
Springer Journals
Copyright
Copyright © 2016 by Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
Subject
Biomedicine; Biomedicine, general; Cancer Research; Metabolic Diseases; Infectious Diseases; Molecular Medicine; Neurosciences
ISSN
1078-8956
eISSN
1546-170X
DOI
10.1038/nm.4107
Publisher site
See Article on Publisher Site

Abstract

In Trp53-mutated hepatocellular carcinoma, conformation-changing aurora kinase A inhibitors disrupt aurora kinase A–MYC interactions, resulting in MYC degradation and suppression of tumor growth.

Journal

Nature MedicineSpringer Journals

Published: May 23, 2016

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