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A Portrait of State-of-the-Art Research at the Technical University of LisbonNanotechnology and the Detection of Biomolecular Recognition Using Magnetoresistive Transducers

A Portrait of State-of-the-Art Research at the Technical University of Lisbon: Nanotechnology and... [An integrated electronic biochip platform for the detection of biomolecular recognition is described. It includes the detection module, where labeled target DNA/antibody molecules are magnetically arrayed towards immobilized probes (cDNA/antigen) and where DNA-cDNA hybridization or antibody-antigen interaction is detected. Magnetic nanobeads are used as labels for targets, and magnetic field sensors are used to detect beads presence. The present device holds 256 probe sites in a matrix containing one magnetic tunnel junction and one thin film PIN diode at each node. A microfluidics chamber and a credit card sized electronics board complete the microsystem. Diagnostic applications include the detection of cystic fibrosis relate gene mutations (DNA chip) and the detection of Salmonella and Es-cherichia coli presence in water (immunoassay).] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

A Portrait of State-of-the-Art Research at the Technical University of LisbonNanotechnology and the Detection of Biomolecular Recognition Using Magnetoresistive Transducers

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Publisher
Springer Netherlands
Copyright
© Springer 2007
ISBN
978-1-4020-5689-5
Pages
3 –22
DOI
10.1007/978-1-4020-5690-1_1
Publisher site
See Chapter on Publisher Site

Abstract

[An integrated electronic biochip platform for the detection of biomolecular recognition is described. It includes the detection module, where labeled target DNA/antibody molecules are magnetically arrayed towards immobilized probes (cDNA/antigen) and where DNA-cDNA hybridization or antibody-antigen interaction is detected. Magnetic nanobeads are used as labels for targets, and magnetic field sensors are used to detect beads presence. The present device holds 256 probe sites in a matrix containing one magnetic tunnel junction and one thin film PIN diode at each node. A microfluidics chamber and a credit card sized electronics board complete the microsystem. Diagnostic applications include the detection of cystic fibrosis relate gene mutations (DNA chip) and the detection of Salmonella and Es-cherichia coli presence in water (immunoassay).]

Published: Jan 1, 2007

Keywords: nanotechnology; nanobiotechnology; biochips; lab-on-a-chip; bioarrays; magnetic beads; magnetoresistive sensors; microfluidics

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