Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

A Practical Guide to Skin CancerMerkel Cell Carcinoma

A Practical Guide to Skin Cancer: Merkel Cell Carcinoma [Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer. The incidence has increased over the past 20 years, and this may be attributed to increased ultraviolet (UV) light exposure. MCC is more common among Caucasians, males, and individuals older than 69 years of age. Immunosuppressed patients are at a higher risk for MCC. MCC may present clinically as a dome-shaped red or blue nodule. The mnemonic “AEIOU” describes common clinical features: asymptomatic, expanding rapidly, immunosuppression, older than 50 years, and ultraviolet-exposed/fair skin. MCC most commonly presents on the head and neck, followed by the extremities and trunk. Diagnosis is made via biopsy, and the first-line treatment is surgical removal of the primary tumor. Sentinel lymph node biopsy (SLNB) is recommended for all patients: patients with negative sentinel lymph nodes (SLNs) may undergo wide local excision (WLE), Mohs micrographic surgery (MMS), or radiation to the primary tumor site. Patients with positive SLNs may undergo WLE or MMS, followed by complete lymph node dissection (CLND) and/or radiation to the nodal basin. Patients with metastatic disease may undergo chemotherapy or immunotherapy. Prognosis for MCC patients depends on the stage of disease: survival rates decrease as the stage advances. Due to the high recurrence rate of MCC, patients are encouraged to see their dermatologists frequently.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

A Practical Guide to Skin CancerMerkel Cell Carcinoma

Editors: Hanlon, Allison
Tsai, Sheena; Bordeaux, Jeremy S.
Springer Journals — May 15, 2018
Download PDF
10 pages

Loading next page...
 
/lp/springer-journals/a-practical-guide-to-skin-cancer-merkel-cell-carcinoma-v9UoVRUrD2
Publisher
Springer International Publishing
Copyright
© Springer International Publishing AG, part of Springer Nature 2018
ISBN
978-3-319-74901-3
Pages
143 –153
DOI
10.1007/978-3-319-74903-7_7
Publisher site
See Chapter on Publisher Site

Abstract

[Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer. The incidence has increased over the past 20 years, and this may be attributed to increased ultraviolet (UV) light exposure. MCC is more common among Caucasians, males, and individuals older than 69 years of age. Immunosuppressed patients are at a higher risk for MCC. MCC may present clinically as a dome-shaped red or blue nodule. The mnemonic “AEIOU” describes common clinical features: asymptomatic, expanding rapidly, immunosuppression, older than 50 years, and ultraviolet-exposed/fair skin. MCC most commonly presents on the head and neck, followed by the extremities and trunk. Diagnosis is made via biopsy, and the first-line treatment is surgical removal of the primary tumor. Sentinel lymph node biopsy (SLNB) is recommended for all patients: patients with negative sentinel lymph nodes (SLNs) may undergo wide local excision (WLE), Mohs micrographic surgery (MMS), or radiation to the primary tumor site. Patients with positive SLNs may undergo WLE or MMS, followed by complete lymph node dissection (CLND) and/or radiation to the nodal basin. Patients with metastatic disease may undergo chemotherapy or immunotherapy. Prognosis for MCC patients depends on the stage of disease: survival rates decrease as the stage advances. Due to the high recurrence rate of MCC, patients are encouraged to see their dermatologists frequently.]

Published: May 15, 2018

Keywords: Merkel cell carcinoma; Skin cancer; Epidemiology; Clinical features; Diagnosis; Histopathology; Staging; Treatment; Prognosis

There are no references for this article.