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A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk AssessmentAdvancing Adverse Outcome Pathways for Risk Assessment

A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment: Advancing... [The Adverse Outcome Pathway (AOP) framework was first proposed by Ankley and colleagues back in 2010 (Ankley et al. Environ Toxicol Chem 29:730–741, 2010). AOPs organize information across biological levels of organization, with common terminology and concepts and with the goal of informing human and ecological risk assessment. Not only was the framework rapidly embraced, it also spearheaded an unprecedented amount of research both nationally and internationally dedicated to understanding, developing, and accepting AOPs. Although developing AOPs has made an impressive start, there are still areas of research that need to be focused on. Many uncertainties remain in the use and acceptance of AOPs for regulatory purposes and this book explores the advancement of AOPs for risk assessment by focusing on different aspects of AOP development such as incorporating behavior, non-model species, invertebrates, plants, synthetic biology and epigenetics. Novel methods for developing predictive tools via quantitative methods are explored, as well as social considerations of barriers to AOP acceptance.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk AssessmentAdvancing Adverse Outcome Pathways for Risk Assessment

Editors: Garcia-Reyero, Natàlia; Murphy, Cheryl A.
Garcia-Reyero, Natàlia; Murphy, Cheryl A.
Springer Journals — Feb 25, 2018
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13 pages

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Publisher
Springer International Publishing
Copyright
© Springer International Publishing AG 2018
ISBN
978-3-319-66082-0
Pages
1 –14
DOI
10.1007/978-3-319-66084-4_1
Publisher site
See Chapter on Publisher Site

Abstract

[The Adverse Outcome Pathway (AOP) framework was first proposed by Ankley and colleagues back in 2010 (Ankley et al. Environ Toxicol Chem 29:730–741, 2010). AOPs organize information across biological levels of organization, with common terminology and concepts and with the goal of informing human and ecological risk assessment. Not only was the framework rapidly embraced, it also spearheaded an unprecedented amount of research both nationally and internationally dedicated to understanding, developing, and accepting AOPs. Although developing AOPs has made an impressive start, there are still areas of research that need to be focused on. Many uncertainties remain in the use and acceptance of AOPs for regulatory purposes and this book explores the advancement of AOPs for risk assessment by focusing on different aspects of AOP development such as incorporating behavior, non-model species, invertebrates, plants, synthetic biology and epigenetics. Novel methods for developing predictive tools via quantitative methods are explored, as well as social considerations of barriers to AOP acceptance.]

Published: Feb 25, 2018

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